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Morphine is an extremely potent opiate analgesic psychoactive drug and is considered to be the prototypical opioid. In clinical medicine, morphine is regarded as the gold standard, or benchmark, of analgesics used to relieve severe or agonizing pain and suffering.
New drug multiplies analgesic effect of opioids without increasing constipation

New drug multiplies analgesic effect of opioids without increasing constipation

Scientists from the University of Granada have taken part, alongside the Esteve laboratory, in the development of a new drug that multiplies the analgesic effect of opioids (drugs for treating intense pain), without increasing constipation, one of the most common side-effects of these drugs, among which is morphine. [More]
Egalet provides business update, reports full year 2013 financial results

Egalet provides business update, reports full year 2013 financial results

Egalet Corporation ("Egalet") today reported business highlights and financial results for the year ended December 31, 2013. This marks the first time that Egalet is reporting its operating results as a public company. [More]
Prescriptions of opioid analgesics increased during U.S. emergency department visits

Prescriptions of opioid analgesics increased during U.S. emergency department visits

George Washington University (GW) researchers report dramatic increases in prescriptions of opioid analgesics, such as Percocet, Vicodin, oxycodone and Dilaudid, during U.S. emergency department visits from 2001 to 2010. [More]

"Doctor shopping" results in increased drug use among postoperative orthopaedic trauma patients

"Doctor shopping," the growing practice of obtaining narcotic prescriptions from multiple providers, has led to measurable increases in drug use among postoperative orthopaedic trauma patients, according to a new study presented today at the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). [More]
Novel scaffold protein regulates mu opioid receptor induced signaling activation

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation. [More]
New approach to breast reconstruction surgery decreases use of postoperative opioid painkiller

New approach to breast reconstruction surgery decreases use of postoperative opioid painkiller

A new approach to breast reconstruction surgery aimed at helping patients' bodies get back to normal more quickly cut their postoperative opioid painkiller use in half and meant a day less in the hospital on average, a Mayo Clinic study found. [More]

AcelRx Pharmaceuticals announces financial results for fourth quarter and full year 2013

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today reported financial results for the three and twelve months ended December 31, 2013. [More]
Photoreactive compounds open new routes to treatment of neurological diseases

Photoreactive compounds open new routes to treatment of neurological diseases

Photoreactive compounds developed by scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich directly modulate nerve-cell function, and open new routes to the treatment of neurological diseases, including chronic pain and certain types of visual impairment. [More]

Nurses in emergency care must be trained to recognise symptoms of meningococcal septicaemia

Nurses working in emergency care environments must be trained to recognise the atypical signs and symptoms of meningococcal septicaemia. [More]

Opiate use alters activity of specific protein needed for normal functioning of brain's reward center

Identifying the specific pathways that promote opioid addiction, pain relief, and tolerance are crucial for developing more effective and less dangerous analgesics, as well as developing new treatments for addiction. [More]
States: Calif. docs fight health law reimbursements; Wis. and collective bargaining; Kan. navigators restrictions

States: Calif. docs fight health law reimbursements; Wis. and collective bargaining; Kan. navigators restrictions

A selection of health policy stories from California, Wisconsin, Kansas, Virginia, Oregon, Georgia, North Carolina and Maine. [More]
First Edition: February 24, 2014

First Edition: February 24, 2014

Today's headlines include continuing coverage of Medicare Advantage payment rates, as well as a range of stories about the health law's Medicaid expansion and online insurance marketplaces. [More]
Research roundup: Palliative care and ACOs; employers and Supreme Court case on contraception

Research roundup: Palliative care and ACOs; employers and Supreme Court case on contraception

In preparation for the new ACO environment, leaders recognized the contribution palliative care can make to health care "value," especially in the care of our sickest (and most expensive) patients ... [More]
Highlights: Vaccine exemption bills rarely become law; Ariz. group urges public hospital changes; Florida foster kids care

Highlights: Vaccine exemption bills rarely become law; Ariz. group urges public hospital changes; Florida foster kids care

Legislation to change whether parents may refuse school vaccinations for their children appears to be common in some states, according to a new analysis. However, those bills are rarely passed into law. Researchers identified 36 bills that were introduced in 18 state legislatures between 2009 and 2012 to change school immunization requirements. Most of those bills aimed to allow more parents the ability to refuse vaccinations for their children (Seaman, 2/12). [More]

First Edition: February 13, 2014

Today's headlines include news coverage of yesterday's update from the Obama administration regarding the number of people who have enrolled in private health insurance through the health law's online marketplaces. [More]
Nociceptin in brain naturally moderates effects of stress

Nociceptin in brain naturally moderates effects of stress

Collaborating scientists at The Scripps Research Institute (TSRI), the National Institutes of Health (NIH) and the University of Camerino in Italy have published new findings on a system in the brain that naturally moderates the effects of stress. [More]
Molecule produced by brain acts as natural defence mechanism against cannabis

Molecule produced by brain acts as natural defence mechanism against cannabis

Two INSERM research teams led by Pier Vincenzo Piazza and Giovanni Marsicano (INSERM Unit 862 "Neurocentre Magendie" in Bordeaux) recently discovered that pregnenolone, a molecule produced by the brain, acts as a natural defence mechanism against the harmful effects of cannabis in animals. [More]
Chinese herbal medicine effective at alleviating acute inflammatory and nerve pain

Chinese herbal medicine effective at alleviating acute inflammatory and nerve pain

A compound derived from a traditional Chinese herbal medicine has been found effective at alleviating pain, pointing the way to a new nonaddictive analgesic for acute inflammatory and nerve pain, according to UC Irvine pharmacology researchers. [More]

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance, hyperalgesia

Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive mechanisms are not well understood. [More]

Research examines link between opioid suppression of immune system and cancer recurrence

‚ÄčThe methods used to anesthetize prostate cancer patients and control pain when their prostate glands are surgically removed for adenocarcinoma may affect their long-term cancer outcomes, a study led by Mayo Clinic has found. [More]