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Opiate use alters activity of specific protein needed for normal functioning of brain's reward center

Opiate use alters activity of specific protein needed for normal functioning of brain's reward center

Identifying the specific pathways that promote opioid addiction, pain relief, and tolerance are crucial for developing more effective and less dangerous analgesics, as well as developing new treatments for addiction. [More]
The surprising effect of cannabis on morphine dependence

The surprising effect of cannabis on morphine dependence

Injections of THC, the active principle of cannabis, eliminate dependence on opiates (morphine, heroin) in rats deprived of their mothers at birth. This has been shown by a study carried out by Valérie Daugé and her team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / INSERM) in the journal Neuropsychopharmacology. The findings could lead to therapeutic alternatives to existing substitution treatments. [More]
Combining morphine with small doses of methadone could increase the effectiveness of morphine for the treatment of chronic pain

Combining morphine with small doses of methadone could increase the effectiveness of morphine for the treatment of chronic pain

Although morphine is well known as a highly effective analgesic, its clinical utility is severely limited by the development of drug tolerance, the requirement for increasing doses to maintain analgesic effect, and the development of physical dependence. [More]