7. November 2009 00:42
A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of Rochester School of Medicine and Dentistry in New York.
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8. September 2009 00:26
Researchers at the University of Illinois have designed a small molecule that blocks an aberrant pathway associated with myotonic dystrophy type 1, the most common form of muscular dystrophy.
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11. August 2009 06:13
Cell biologists from the Radboud University Nijmegen Medical Centre (Nijmegen, the Netherlands) describe a new approach to remove the toxic agent that causes the neuromuscular disease myotonic dystrophy. Their findings are published in the scientific journal The Proceedings of the National Academy of Sciences.
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9. August 2009 20:31
Chemists at the University at Buffalo have used rational drug design to synthesize small, cell-permeable molecules that are effective in vitro against two common types of myotonic muscular dystrophy, a result that has implications for potentially curing muscular dystrophy, as well as other diseases.
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17. July 2009 03:17
Researchers at the University of Rochester Medical Center have found a way to block the genetic flaw at the heart of a common form of muscular dystrophy. The results of the study, which were published today in the journal Science, could pave the way for new therapies that essentially reverse the symptoms of the disease.
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5. May 2009 19:03
Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found.
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Posted in: Medical Research News
Tags: Biochemistry, Biotechnology, DNA, Embryonic Development, Fragile X Syndrome, Genetics, Huntington's Disease, Joseph Disease, Myotonic Dystrophy, Pharmacology, Physiology, siRNA
3. May 2009 20:24
Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found.
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89f26749-71e7-44a5-bee6-efc1ebf46428|0|.0
Posted in: Medical Research News
Tags: Biochemistry, Biotechnology, DNA, Embryonic Development, Fragile X Syndrome, Genetics, Huntington's Disease, Joseph Disease, Myotonic Dystrophy, Pharmacology, siRNA
8. December 2008 21:23
Just as the emotions it represents are dynamic, the heart's development requires dynamic shifts in proteins that prompt alternative spicing, a mechanism that allows a given gene to program the cell to make several proteins, said a group of researchers at Baylor College of Medicine in a report that appears online in the journal Proceedings of the National Academy of Sciences.
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19. November 2008 18:12
Using a drug-discovery technique in which molecules compete against each other for access to the target - the strand of toxic RNA that causes the most common form of muscular dystrophy in adults - a team at the University of Rochester Medical Center has identified several compounds that, in the laboratory, block the unwanted coupling of two molecules that is at the root of the disease.
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19. June 2008 04:03
The largest assessment of people with adult muscular dystrophy has identified risk factors that can lead to sudden death for individuals with the most common form of this disease.
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27. May 2008 15:52
Expanding on prior research performed at the University of Pennsylvania, Penn biologists have determined that faulty RNA, the blueprint that creates mutated, toxic proteins, contributes to a family of neurodegenerative disorders in humans.
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Posted in: Medical Research News
Tags: Alzheimer's Disease, Amino Acid, Biochemistry, Fragile X Syndrome, Genetics, Glutamine, Huntington's Disease, Myotonic Dystrophy, Nervous System, Neurodegeneration, Parkinson's Disease, Stroke
21. May 2008 19:51
Expanding on prior research performed at the University of Pennsylvania, Penn biologists have determined that faulty RNA, the blueprint that creates mutated, toxic proteins, contributes to a family of neurodegenerative disorders in humans.
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3. December 2007 11:17
Practice parameters published in the December 1 issue of the journal SLEEP serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin, including idiopathic hypersomnia, recurrent hypersomnia and hypersomnia due to medical condition.
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Posted in: Drug Trial News
Tags: Anxiety, Caffeine, Exercise, Multiple Sclerosis, Myotonic Dystrophy, Narcolepsy, Paralysis, Serotonin, Sleep, Sleep Disorder, Sleep Paralysis, Speech, Venlafaxine
16. November 2007 02:01
Researchers at the University of Rochester Medical Center (URMC) have identified a compound that eliminates myotonia - a symptom of muscular dystrophy - in mice. The research was published online in the Journal of Clinical Investigation.
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16. November 2007 00:23
In addition to the progressive muscle weakness and degeneration common to all forms of muscular dystrophy, patients with the most common form of muscular dystrophy affecting adults, myotonic dystrophy type 1 (DM1), also experience an inability to voluntarily relax the muscles (a problem known as myotonia).
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