Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

Study explores time trends in pregnancy-related outcomes among women with type 1 diabetes

Researchers from the Joslin Diabetes Center investigated time trends in pregnancy-related outcomes among women with type 1 diabetes between 2004 and 2017, and found that the percentage of mothers with excess weight gain during pregnancy as well as the use of insulin pumps and CGMs increased significantly, while the prevalence of nephropathy fell dramatically to zero.

30 Jun 2020

Octapharma extends support for COVID-19 study following promising preliminary data

Following positive preliminary data, Octapharma USA is extending funding for an investigator-initiated study (IIS) focused on treating the most critical patients at the heart of the coronavirus pandemic, those experiencing hypoxia and who are at the highest risk of requiring mechanical ventilation.

3 Jun 2020

FDA approves IND application by Octapharma USA for severe COVID-19 patients

The U.S. Food and Drug Administration (FDA) has approved the investigational new drug (IND) application submitted by Octapharma USA for a phase three clinical trial on the efficacy and safety of Octagam 10% [Immune Globulin Intravenous (Human)] therapy in COVID-19 patients with severe disease progression.

20 May 2020

Study suggests ROBO2 pathway as therapeutic target for kidney diseases

Researchers have published a new study that suggests a signaling pathway called ROBO2 is a therapeutic target for kidney diseases, specifically kidney podocyte injury and glomerular diseases.

4 May 2020

Analysis of causative protein genotype can help predict Alport syndrome severity

A Japanese research team has successfully developed a system to predict the severity of Alport syndrome, a serious hereditary kidney disease that occurs in about 1 out of 5,000 people in the US. Patients with Alport syndrome have abnormalities in the causative protein, type IV collagen, that often lead to chronic renal dysfunction requiring dialysis.

6 Apr 2020

Grip strength metrics may be useful screening tool for diabetes risk

A new study in the American Journal of Preventive Medicine, published by Elsevier, reports valuable new grip strength metrics that provide healthcare practitioners with an easy-to-perform, time-efficient screening tool for type 2 diabetes.

6 Apr 2020

Participation of people with diabetes in online support groups associated with poorer health

Diabetes is a disease that affects people's lives more in the long term and requires emotional support and information. It is increasingly common for people with diabetes to participate in digital communities and seek help in so-called OSGs (online support groups) to share experiences and glean information.

19 Mar 2020

Weight loss lasts long after bariatric surgery, study finds

Weight loss was maintained better after gastric bypass than after sleeve gastrectomy in large study of diverse patients in Washington and California.

17 Mar 2020

Preserving kidney function in patients with diabetic kidney disease

Diabetic kidney disease, which affects between 20 to 40 percent of people with diabetes, is a serious complication that can ultimately lead to end-stage kidney disease--a life-threatening condition that requires either dialysis or kidney transplant.

13 Mar 2020

Scientists identify genes involved in the development of diabetic kidney disease

By analyzing samples from hundreds of Finns with diabetes, scientists have identified genes, and the proteins they encode, that could be involved in the development of diabetic kidney disease.

12 Mar 2020

Low socioeconomic status associated with certain kidney diseases

A new study found an inverse association between socioeconomic status and certain kidney diseases. The findings appear in an upcoming issue of CJASN.

20 Feb 2020

Weed-derived compounds in Serbian groundwater linked to endemic nephropathy

People living in Balkan farming villages along the Danube River have long suffered from a unique type of kidney disease known as Balkan endemic nephropathy.

19 Feb 2020

PERL study: Reducing uric acid levels does not benefit type 1 diabetes patients with kidney disease

Diabetic kidney disease remains one of the most intractable complications of diabetes. Progress has been made using glycemic and blood pressure control, but the search continues for improved treatments for the estimated one in four adults with diabetes who has some level of nephropathy and continues at risk for eventual kidney failure.

10 Nov 2019

New tool accurately predicts risks of death, complications from obesity and diabetes

A new web-based risk calculator can accurately predict the likelihood a patient with type 2 diabetes and obesity will die or develop serious complications including a heart attack, heart failure and diabetic kidney disease (nephropathy) within the next 10 years.

6 Nov 2019

UAB researchers find key role for IgG autoantibodies in IgA nephropathy

The most common form of the kidney disease called glomerulonephritis is IgA nephropathy.

24 Sep 2019

Metabolic surgery improves health in obese diabetics

Paris is hosting the European Society of Cardiology Congress (ESC) meet this year where on the 2nd of September researchers from the Cleveland Clinic reveal that weight loss surgeries in patients with obesity and type 2 diabetes could reduce the risk death and major untoward heart or cardiovascular events or major adverse cardiovascular events (MACE).

3 Sep 2019

Cell-free DNA identifies pathogens and quantifies injuries to organs

A common problem in diagnosing infectious disease is that the presence of a potential pathogen in the body does not necessarily mean the patient is sick. This can be particularly challenging for the treatment of organ transplant recipients, who often grapple with infection as well as complications related to immunosuppression.

29 Aug 2019

How much control is too much in type 1 diabetes?

Type 1 diabetes mellitus (T1DM) affects thousands of children, and causes high sugar levels because of low insulin production. In places with good access to medical care, blood glucose is first measured by capillary blood testing or continuous monitoring. Insulin is given as required by subcutaneous injection or insulin pump.

29 Aug 2019

Study shows how blood glucose levels affect risks in type 1 diabetes

A major new study on the association between blood glucose levels and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care, in the researchers’ view.

28 Aug 2019