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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.
New study provides better understanding of how stem cells give rise to tumors

New study provides better understanding of how stem cells give rise to tumors

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers. [More]
Research opens door to development of new therapies to block HIV-associated neurocognitive disorders

Research opens door to development of new therapies to block HIV-associated neurocognitive disorders

While antiretroviral therapies have significantly improved and extended the lives of many HIV patients, another insidious and little discussed threat looms for aging sufferers - HIV-associated neurocognitive disorders (HAND). The disorders, which strike more often in HIV patients over age 50, can result in cognitive impairment, mild to severe, making everyday tasks a challenge. [More]
ADDF awards grant to support initiation of AGB101 Phase 3 trial for aMCI treatment

ADDF awards grant to support initiation of AGB101 Phase 3 trial for aMCI treatment

The Alzheimer's Drug Discovery Foundation announced today a $900,000 grant to AgeneBio, a pharmaceutical company developing innovative therapies for neurologic and psychiatric diseases. The grant will support the initiation of an FDA-registered Phase 3 clinical trial of AGB101, a new therapeutic treatment for amnestic mild cognitive impairment (aMCI). [More]
Sanford-Burnham researchers use human pluripotent stem cells to grow new hair

Sanford-Burnham researchers use human pluripotent stem cells to grow new hair

In a new study from Sanford-Burnham Medical Research Institute, researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. [More]
Interacting neurodegenerative changes promote Parkinson’s cognitive decline

Interacting neurodegenerative changes promote Parkinson’s cognitive decline

Research indicates that neurodegeneration in the cholinergic system in the brain is a major contributor to cognitive decline in patients with Parkinson’s disease. [More]
Clinical markers help identify PD patients with cholinergic deficits

Clinical markers help identify PD patients with cholinergic deficits

Assessing patients for clinical markers of cholinergic system denervation is viable and can help identify suitable individuals for trials of new anticholinergic drugs, researchers believe. [More]
Neuroimaging markers have synergistic effect on cognitive decline

Neuroimaging markers have synergistic effect on cognitive decline

The Alzheimer disease neuroimaging markers β-amyloid and neurodegeneration have synergistic effects on the rate of cognitive decline in clinically normal people, research shows. [More]
Sanford-Burnham, Mayo Clinic scientists to jointly find new treatment for resistant hypertension

Sanford-Burnham, Mayo Clinic scientists to jointly find new treatment for resistant hypertension

Sanford-Burnham Medical Research Institute at Lake Nona and Mayo Clinic today announced that a joint team of scientists has been selected as a winner of GlaxoSmithKline's 2014 Discovery Fast Track Challenge. [More]
Leaders in research hope to uncover promising drugs in pharma libraries, conduct clinical trials

Leaders in research hope to uncover promising drugs in pharma libraries, conduct clinical trials

Drugs for brain diseases such as Alzheimer's, Parkinson's, and motor neurone disease that have stalled in development could be revived thanks to the efforts of a global coalition of non-profit organizations and funders announced today. [More]
Researchers identify molecular switch that controls inflammatory processes in aging-related disorders

Researchers identify molecular switch that controls inflammatory processes in aging-related disorders

A study led by Massachusetts General Hospital (MGH) investigators has identified what appears to be a molecular switch controlling inflammatory processes involved in conditions ranging from muscle atrophy to Alzheimer's disease. [More]
Study looks at new diagnostic, treatment approaches to neurological conditions

Study looks at new diagnostic, treatment approaches to neurological conditions

Despite great advances in understanding how the human brain works, psychiatric conditions, neurodegenerative disorders, and brain injuries are on the rise. Progress in the development of new diagnostic and treatment approaches appears to have stalled. In a special issue of the Cell Press journal Neuron, experts look at the challenges associated with "translational neuroscience," or efforts to bring advances in the lab to the patients who need them. [More]
Scientists uncover small set of genes critical in aging and neurodegenerative disease

Scientists uncover small set of genes critical in aging and neurodegenerative disease

Aging is the most significant and universal risk factor for developing neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer's, Parkinson's and Huntington's diseases. This risk increases disproportionately with age, but no one really knows why. [More]
Tau proteins spur neuron death in Alzheimer's disease

Tau proteins spur neuron death in Alzheimer's disease

New research points to tau, not amyloid-beta (Abeta) plaque, as the seminal event that spurs neuron death in disorders such as Alzheimer's disease. The finding, which dramatically alters the prevailing theory of Alzheimer's development, also explains why some people with plaque build-up in their brains don't have dementia. [More]
TSRI scientists discover signaling pathway that contribute to Huntington's disease

TSRI scientists discover signaling pathway that contribute to Huntington's disease

Scientists from the Florida campus of The Scripps Research Institute have uncovered a major contributor to Huntington's disease, a devastating progressive neurological condition that produces involuntary movements, emotional disturbance and cognitive impairment. [More]
Digoxin drug may be adaptable for ALS treatment, study suggests

Digoxin drug may be adaptable for ALS treatment, study suggests

Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new research at Washington University School of Medicine in St. Louis. [More]
Nonmotor predictors of Parkinson’s dementia revealed

Nonmotor predictors of Parkinson’s dementia revealed

Researchers have identified nonmotor and nondopaminergic motor features that predict incident dementia in patients with Parkinson’s disease. [More]
Researchers uncover surprising way to reduce brain damage caused by head injuries

Researchers uncover surprising way to reduce brain damage caused by head injuries

Scientists have uncovered a surprising way to reduce the brain damage caused by head injuries - stopping the body's immune system from killing brain cells. The study, published in the open access journal Acta Neuropathologica Communications, showed that in experiments on mice, an immune-based treatment reduced the size of brain lesions. [More]
Researchers propose new milestones to augment National Alzheimer's Plan

Researchers propose new milestones to augment National Alzheimer's Plan

The U.S. Government has initiated a major effort to prevent and effectively treat Alzheimer's disease by 2025. However, a workgroup of nearly 40 Alzheimer's researchers and scientists says the research milestones in the U.S. Government's National Plan to Address Alzheimer's Disease must be broadened in scope, increased in scale, and adequately funded in order to successfully achieve this goal. [More]
Scientists identify two microRNA molecules that control chronic inflammation

Scientists identify two microRNA molecules that control chronic inflammation

University of Utah scientists have identified two microRNA molecules that control chronic inflammation, a discovery that one day may help researchers prevent certain fatal or debilitating conditions before they start. [More]
Researchers identify two microRNA molecules that control chronic inflammation

Researchers identify two microRNA molecules that control chronic inflammation

University of Utah scientists have identified two microRNA molecules that control chronic inflammation, a discovery that one day may help researchers prevent certain fatal or debilitating conditions before they start. [More]
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