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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.
Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production. [More]
TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

A new study led by scientists at The Scripps Research Institute suggests that cells construct protein "clumps" to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig's disease. [More]
Long-term exercise may benefit Spinal Muscular Atrophy patients

Long-term exercise may benefit Spinal Muscular Atrophy patients

Long-term exercise appears to be beneficial for Spinal Muscular Atrophy (SMA) like mice, suggesting a potential of active physiotherapy for patient care; according to a study published today in the Journal of Physiology. [More]
Study highlights new approach to produce coral snake antivenom from synthetically designed DNA

Study highlights new approach to produce coral snake antivenom from synthetically designed DNA

Coral snake venom carries significant neurotoxicity and human injuries can be severe or even lethal. Despite this, antivenom treatments are scarce due to challenges collecting adequate amounts of venom needed to produce anti-elapidic serum. PLOS Neglected Tropical Diseases highlights exciting new research from the Butantan Institute in Brazil using synthetically designed DNA to produce coral-snake antivenom. [More]
Researchers find way to inhibit enzyme responsible for Alzheimer's disease

Researchers find way to inhibit enzyme responsible for Alzheimer's disease

For decades, intensive research has been conducted on drugs all over the world to treat Alzheimer's patients. Although major progress has been made in diagnostics (the disease can be detected increasingly early and accurately), the therapeutic options remain limited. [More]
SBP study opens door for new approaches to treat muscle diseases

SBP study opens door for new approaches to treat muscle diseases

Scientists at Sanford Burnham Prebys Medical Discovery Institute have found a key to enhancing repair of damaged muscle. In work published today in Cell Reports, scientists describe why fetal muscle stem cells (MuSCs) are better at regenerating muscle compared to adult MuSCs. [More]
Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

For rent: 32 individual rooms for a combined surface area of 4cm2, heating and food included! Biologists and microfluidics specialists at EPFL have joined forces and developed a highly innovative research tool: a 2cm by 2cm 'chip' with 32 independent compartments, each of which is designed to hold a nematode - a widely used worm in the research world. The device is described in the journal Molecular Neurodegeneration. [More]
Anti-cancer drug delays onset of Alzheimer's disease

Anti-cancer drug delays onset of Alzheimer's disease

Researchers have identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer's disease, in a similar way to how statins are able to reduce the risk of developing heart disease. [More]
Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Could a kinase inhibitor some doctors prescribe to keep blood flowing after brain surgery be used to treat neurodegeneration? New research suggests it might be worth exploring the question. [More]
Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

Stopping disruptions in cellular "trash removal" brought on by errors in molecular marks on DNA may guard against neurodegenerative diseases like Parkinson's. [More]
Stem cell transplantation of neurotrophic factors shows promise in ALS

Stem cell transplantation of neurotrophic factors shows promise in ALS

Mesenchymal stem cells cultured to secrete neurotrophic factors can be administered to patients with amyotrophic lateral sclerosis without lasting unwanted effects and may have clinical benefits, indicates a phase I/II safety analysis study. [More]
Researchers identify protein that could protect against toxic degeneration of cells in ALS

Researchers identify protein that could protect against toxic degeneration of cells in ALS

J. Gavin Daigle, a PhD candidate at the LSU Health New Orleans School of Graduate Studies, is the first author of a paper whose findings reveal another piece of the Amyotrophic Lateral Sclerosis (ALS) puzzle. [More]
New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

New UTMB study reveals link between traumatic brain injury and Alzheimer's disease

A new study from The University of Texas Medical Branch at Galveston fills an important gap in understanding the link between traumatic brain injury and neurodegenerative disorders such as Alzheimer's disease. [More]
Araim Pharmaceuticals forms new strategic collaboration with Vault Bioventures to market novel peptides

Araim Pharmaceuticals forms new strategic collaboration with Vault Bioventures to market novel peptides

Araim Pharmaceuticals has formed a long-term strategic partnership with Vault Bioventures to facilitate the advancement to market of its novel peptide library which targets devastating injuries and chronic diseases underserved by current therapies. [More]
Areas stricken by extreme poverty more likely to be associated with high rates of Ebola transmission

Areas stricken by extreme poverty more likely to be associated with high rates of Ebola transmission

Since October 2014 the Ebola epidemic in West Africa has been diminishing and efforts have shifted from emergency response to prevention and mitigation of future outbreaks. Researchers from the Liberian Ministry of Health and the Yale Center for Infectious Disease Modelling and Analysis evaluated 3532 Ebola cases reported in 2014 in order to quantify the impact of poverty on the transmission and spread of Ebola. [More]
Study reveals new genetic factors linked to age-related macular degeneration

Study reveals new genetic factors linked to age-related macular degeneration

An international study of about 43,000 people has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older. [More]
Drug that boosts activity in the brain's 'garbage disposal' system may slow Alzheimer's disease

Drug that boosts activity in the brain's 'garbage disposal' system may slow Alzheimer's disease

A drug that boosts activity in the brain's "garbage disposal" system can decrease levels of toxic proteins associated with Alzheimer's disease and other neurodegenerative disorders and improve cognition in mice, a new study by neuroscientists at Columbia University Medical Center has found. [More]
Researchers elucidate structure of mTORC1 protein

Researchers elucidate structure of mTORC1 protein

For a long time it has been known that the protein TOR - Target of Rapamycin - controls cell growth and is involved in the development of diseases such as cancer and diabetes. Researchers at the University of Basel's Biozentrum together with scientists from ETH Zurich have now examined the structure of mammalian TOR complex 1 (mTORC1) in more detail. [More]
Reagents for Autophagy Research

Reagents for Autophagy Research

AMSBIO has assembled an extensive collection of autophagy antibodies. From the industry standard autophagy antibody APG8 (MAPLC3) to the newest autophagy antibodies such as LAMP and APG1, AMSBIO is able to provide the most relevant, qualified antibodies for autophagy research. [More]
Researchers set up citizen science program to gain insight into triatomine insects in Texas

Researchers set up citizen science program to gain insight into triatomine insects in Texas

Chagas disease is caused by a parasitic protozoan (Trypanosoma cruzi) and transmitted via triatomine insects known locally in Texas as "kissing bugs". Due to the success of community based triatomine surveillance and collection in Central and South America, researchers from Texas A & M University set up a citizen science program to gain insight into the distribution and infection prevalence of triatomine insects in Texas. [More]
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