Neurodegeneration News and Research RSS Feed - Neurodegeneration News and Research

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.
Resolution of inflammation is altered in Alzheimer's disease

Resolution of inflammation is altered in Alzheimer's disease

New research from Karolinska Institutet in Sweden shows that the final stage of the normal inflammatory process may be disrupted in patients with Alzheimer's disease. [More]

Final stage of normal inflammatory process may be disrupted in patients with Alzheimer's disease

New research from Karolinska Institutet in Sweden shows that the final stage of the normal inflammatory process may be disrupted in patients with Alzheimer's disease. A study published in the journal Alzheimer's & Dementia shows that levels in the brain and cerebrospinal fluid of the molecules necessary for tissue recovery through the clearance of harmful inflammatory substances are lower than normal in patients with Alzheimer's disease. The study also showed association between the lower levels of these molecules with impaired memory function. [More]
Scientists find a clue as to why muscles weaken with age

Scientists find a clue as to why muscles weaken with age

Scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio have found a clue as to why muscles weaken with age. In a study published Feb. 5 in The Journal of Neuroscience, they report the first evidence that "set points" in the nervous system are not inalterably determined during development but instead can be reset with age. They observed a change in set point that resulted in significantly diminished motor function in aging fruit flies. [More]
Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

Researchers from North Carolina State University have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers. [More]
Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

In a study published this week in Nature Neuroscience, Bess Frost, PhD, and co-authors, identify abnormal expression of genes, resulting from DNA relaxation, that can be detected in the brain and blood of Alzheimer's patients. [More]
FARA funds gene therapy-based research project to tackle Friedreich's ataxia

FARA funds gene therapy-based research project to tackle Friedreich's ataxia

The gene therapy-based research project to tackle Friedreich's ataxia launched in November in labs at the Institute for Research in Biomedicine, in Barcelona, and the "Centro de Biolog-a Molecular Severo Ochoa", in Madrid, has received 100,000 US$ per year for two years from the Friedreich's Ataxia Research Alliance. [More]
Biomarker used to diagnose brain injury shows early promise for assessing heart inflammation

Biomarker used to diagnose brain injury shows early promise for assessing heart inflammation

A biomarker widely used to diagnose brain injury has shown early promise for assessing the severity of heart inflammation, or myocarditis, find researchers at Columbia University's Mailman School of Public Health, Johns Hopkins, and the Mayo Clinic. [More]
CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron. [More]

Researcher finds possible way to unravel misfolded proteins by reprogramming yeast protein

At the heart of brain diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At present, there is no known way to reverse protein misfolding. [More]
THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

THRIL could be novel biomarker for immune activation, potential target for inflammatory diseases

Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells-macrophages-are stimulated in response to pathogens. [More]

NUS scientists open possible new route for treatment of spinal muscular atrophy

A recent study led by scientists from the National University of Singapore (NUS) opens a possible new route for treatment of Spinal Muscular Atrophy (SMA), a devastating disease that is the most common genetic cause of infant death and also affects young adults. [More]
Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses. [More]

Retrophin to acquire privately-held company, Kyalin Biosciences

Retrophin, Inc. today announced that it will acquire privately-held Kyalin Biosciences, Inc., an early-stage company based in San Diego, CA, that is developing therapies targeting the core symptoms of autism and related conditions. [More]

Retrophin signs agreement with Novartis for exclusive U.S. license for Syntocinon Nasal Spray

Retrophin, Inc. today announced that it has signed an agreement with Novartis Pharma AG for an exclusive U.S. license for Syntocinon Nasal Spray, the intranasal formulation of a synthetic version of the naturally occurring peptide hormone oxytocin, for an upfront payment of $5.0 million plus milestone payments and royalties. [More]
Mitochondrial enzyme SIRT5 regulates proteins involved in metabolism

Mitochondrial enzyme SIRT5 regulates proteins involved in metabolism

The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation. [More]
Scientists identify key factor for limiting inflammatory responses, particularly in skin

Scientists identify key factor for limiting inflammatory responses, particularly in skin

Sanford-Burnham scientists have identified the B and T Lymphocyte Attenuator (BTLA) inhibitory receptor as a key factor in limiting inflammatory responses, particularly in the skin. The study, published online today in Immunity, provides clarity on how T cells get fired up to protect against pathogens, and then cool down to restore immune homeostasis. [More]
Researchers take important step towards development of future drugs for brain diseases

Researchers take important step towards development of future drugs for brain diseases

A successful joint collaboration between researchers at the Hebrew university of Jerusalem and the startup company TyrNovo may lead to a potential treatment of brain diseases. The researchers found that TyrNovo's novel and unique compound, named NT219, selectively inhibits the process of aging in order to protect the brain from neurodegenerative diseases, without affecting lifespan. This is a first and important step towards the development of future drugs for the treatment of various neurodegenerative maladies. [More]
Mutation in alpha-synuclein gene causes increased vulnerability to pesticides, leading to Parkinson's

Mutation in alpha-synuclein gene causes increased vulnerability to pesticides, leading to Parkinson's

‚ÄčA team of researchers has brought new clarity to the picture of how gene-environmental interactions can kill nerve cells that make dopamine. Dopamine is the neurotransmitter that sends messages to the part of the brain that controls movement and coordination. [More]
Protecting or boosting neurotrophins may slow progression of Huntington's disease

Protecting or boosting neurotrophins may slow progression of Huntington's disease

A drug that acts like a growth-promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience. The findings add to a growing body of evidence that protecting or boosting neurotrophins - the molecules that support the survival and function of nerve cells - may slow the progression of Huntington's disease and other neurodegenerative disorders. [More]
Inhibitor compounds could form basis of new treatments for such diseases as MRSA, anthrax

Inhibitor compounds could form basis of new treatments for such diseases as MRSA, anthrax

‚ÄčInhibitor compounds developed by UC Irvine structural biologists and Northwestern University chemists have been shown to bolster the ability of antibiotics to treat deadly bacterial diseases such as MRSA and anthrax. [More]