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Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Clinical trials and translational medicine have certainly given people hope and rapid pathways to cures for some of mankind's most troublesome diseases, but now is not the time to overlook the power of basic research, says UC Santa Barbara neuroscientist Kenneth S. Kosik. [More]
Novel marine natural product appears to reduce pancreatic tumor size

Novel marine natural product appears to reduce pancreatic tumor size

Scientists at Florida Atlantic University's Harbor Branch Oceanographic Institute found that a deep-water marine sponge collected off of Fort Lauderdale's coast contains leiodermatolide, a natural product that has the ability to inhibit the growth of cancer cells as well as block cancer cells from dividing using extremely low concentrations of the compound. [More]
Inosine treatment can help restore motor control after cortical injury

Inosine treatment can help restore motor control after cortical injury

Brain tissue can die as the result of stroke, traumatic brain injury, or neurodegenerative disease. When the affected area includes the motor cortex, impairment of the fine motor control of the hand can result. [More]
Large study of familial ALS finds new gene variant present in 3% of all patients with disease

Large study of familial ALS finds new gene variant present in 3% of all patients with disease

Variations in a gene with multiple functions in neurons are present in approximately 3 percent of all cases of ALS in North American and European populations, both sporadic and familial, making it one of the most common genetic causes of the disease, according to a paper published in Nature Genetics. [More]
Promising new therapeutic target could lead to better prognosis of spinal muscular atrophy

Promising new therapeutic target could lead to better prognosis of spinal muscular atrophy

According to studies, approximately one out of every 40 individuals in the United States is a carrier of the gene responsible for spinal muscular atrophy (SMA), a neurodegenerative disease that causes muscles to weaken over time. [More]
DPUK brings organisations together to tackle dementia across the UK

DPUK brings organisations together to tackle dementia across the UK

Dementia, is an overall term that describes a wide range of symptoms that includes memory loss and difficulties with thinking, is caused when the brain cells degenerate and die more quickly than they would as part of the normal ageing process. [More]
Researchers develop new screening system to measure protein aggregates

Researchers develop new screening system to measure protein aggregates

Researchers from the Massachusetts Institute of Technology and Boston University have developed a system capable of quickly screening millions of yeast cells to measure protein aggregates. [More]
VIB research reveals new insights into ALS

VIB research reveals new insights into ALS

Research into amyotrophic lateral sclerosis (ALS) conducted by VIB-KU Leuven has led to interesting and unexpected conclusions. [More]
Scientists identify timing of major metabolic shift in developing neurons

Scientists identify timing of major metabolic shift in developing neurons

Our brains can survive only for a few minutes without oxygen. Salk Institute researchers have now identified the timing of a dramatic metabolic shift in developing neurons, which makes them become dependent on oxygen as a source of energy. [More]
Neuroscientists identify two distinct populations of dopamine neurons involved in movement, reward

Neuroscientists identify two distinct populations of dopamine neurons involved in movement, reward

Two Northwestern University neuroscientists have identified the neurochemical signal likely missing in Parkinson's disease by being the first to discover two distinctly different kinds of neurons that deliver dopamine to an important brain region responsible for both movement and learning/reward behavior. [More]
TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

Traumatic brain injury (TBI) with a loss of consciousness (LOC) may be associated with later development of Parkinson's disease but not Alzheimer's disease or incident dementia, according to a study conducted at the Icahn School of Medicine at Mount Sinai and the University of Washington School of Medicine. [More]
Study shows miR-19 helps new neurons in the adult brain stay on track

Study shows miR-19 helps new neurons in the adult brain stay on track

A small stretch of ribonucleic acid called microRNA could make the difference between a healthy adult brain and one that's prone to disorders including schizophrenia. [More]
Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics, a drug development company specialized in the discovery and development of new drugs for orphan diseases, today announces the initiation of its first-in-man Phase 1 clinical trial for its lead compound MIN-102. [More]
Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

Researchers identify potential biomarker for Parkinson's disease in biobanked urine samples

For more than five years, urine and cerebral-spinal fluid samples from patients with Parkinson's disease have been locked in freezers in the NINDS National Repository, stored with the expectation they might someday help unravel the still-hidden course of this slow-acting neurodegenerative disease. [More]
Replacing saturated fats with unsaturated fats in diet can confer substantial health benefits

Replacing saturated fats with unsaturated fats in diet can confer substantial health benefits

Consuming higher amounts of unsaturated fats was associated with lower mortality, according to a study from Harvard T.H. Chan School of Public Health. [More]
Study finds link between copper exposure and prion protein neurotoxicity

Study finds link between copper exposure and prion protein neurotoxicity

Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. [More]
Scientists use Sanger sequencing to conduct detailed genetic screening of PD patients

Scientists use Sanger sequencing to conduct detailed genetic screening of PD patients

A team of scientists at the University of Granada has used a next-generation genetic sequencing method and a technique known as "Sanger sequencing" to conduct a detailed genetic screening of patients in Granada suffering from Parkinson's disease. [More]
Fetal BPA exposure leads to harmful change in adult uterine response to estrogens

Fetal BPA exposure leads to harmful change in adult uterine response to estrogens

Low levels of BPA exposure may be considered safe, but new research published online in The FASEB Journal, suggests otherwise. In the report, researchers from Yale show that the genome is permanently altered in the uterus of mice that had been exposed to BPA during their fetal development. [More]
Complex 36-point therapeutic personalized program can help reverse memory loss in early AD patients

Complex 36-point therapeutic personalized program can help reverse memory loss in early AD patients

Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer's disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging. [More]
Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

The metabolite of a drug that is helping patients battle multiple sclerosis appears to significantly slow the onset of Parkinson's disease, researchers say. [More]
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