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Experimental drug may prevent development of multiple sclerosis in mice

Experimental drug may prevent development of multiple sclerosis in mice

The experimental drug laquinimod may prevent the development or reduce the progression of multiple sclerosis (MS) in mice, according to research published in the September 21, 2016, online issue of Neurology Neuroimmunology & Neuroinflammation, a medical journal of the American Academy of Neurology. [More]
HMS study reveals key instigator of nerve cell damage in ALS patients

HMS study reveals key instigator of nerve cell damage in ALS patients

Scientists from Harvard Medical School have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, or ALS, a progressive and incurable neurodegenerative disorder. [More]
Scientists examine how neural responses change over time in patients with Parkinson's disease

Scientists examine how neural responses change over time in patients with Parkinson's disease

Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time. [More]
Study finds risk markers for Parkinson's disease hiding in unusual spots

Study finds risk markers for Parkinson's disease hiding in unusual spots

Clues that point toward new risk mechanisms for developing Parkinson's disease are hiding in some unusual spots, according to a study published today in Scientific Reports [More]
Researchers discover pathway linking oxidative stress and cysteine in Huntington's disease

Researchers discover pathway linking oxidative stress and cysteine in Huntington's disease

Researchers at Johns Hopkins Medicine report they have identified a biochemical pathway linking oxidative stress and the amino acid cysteine in Huntington's disease. [More]
Bone marrow transplantation may one day be beneficial to subset of ALS, say researchers

Bone marrow transplantation may one day be beneficial to subset of ALS, say researchers

Harvard Stem Cell Institute researchers at Harvard University and the Broad Institute of Harvard and MIT have found evidence that bone marrow transplantation may one day be beneficial to a subset of patients suffering from amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder more commonly known as Lou Gehrig's disease. [More]
Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics, a drug development company specialized in the discovery and development of new drugs for orphan diseases, today announces the initiation of its first-in-man Phase 1 clinical trial for its lead compound MIN-102. [More]
Study provides new insight into poorly understood effects of high explosive blasts in male soldiers

Study provides new insight into poorly understood effects of high explosive blasts in male soldiers

Scientists have identified a distinctive pattern of injury in the brains of eight deceased military personnel who survived high explosive attacks and died between 4 days and 9 years later from their injuries or other causes. [More]
Buck researchers identify new, potential drug targets for sporadic PD

Buck researchers identify new, potential drug targets for sporadic PD

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally. [More]
Study demonstrates therapeutic potential of SOD-mimetic compound M40403 against Parkinson disease

Study demonstrates therapeutic potential of SOD-mimetic compound M40403 against Parkinson disease

Parkinson disease is a debilitating and incurable neurodegenerative disorder, affecting approximately 1-2% of people over sixty-five years old. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic exposure to the pesticide paraquat with the incidence of the disease, most probably through the generation of oxidative damage. [More]
Penn neurologists uncover new genetic cause of Charcot-Marie-Tooth Disease

Penn neurologists uncover new genetic cause of Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth Disease (CMT) is a family of inherited disorders of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most of which have to date been linked to a small set of causative genes. [More]
Study identifies biomarker that plays role in early stages of Alzheimer's disease

Study identifies biomarker that plays role in early stages of Alzheimer's disease

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease. [More]
Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells may play greater role in Alzheimer's disease than originally thought

Immune cells that normally help us fight off bacterial and viral infections may play a far greater role in Alzheimer's disease than originally thought, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders. [More]
Study finding could shed light on molecular mechanisms underlying Huntington's disease

Study finding could shed light on molecular mechanisms underlying Huntington's disease

Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. [More]
Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Researchers reveal secondary structure of Lewy bodies in the brain of Parkinson's disease patients

Lewy bodies had been considered to be a key element of pathogenesis for Parkinson's disease. Although structural analysis for Lewy bodies with an electron microscope had been performed, it had no secondary structural information of proteins, which is important for the development of drugs. [More]
Concussion expert shares important information on sports-related concussions

Concussion expert shares important information on sports-related concussions

The Sports Concussion Program in the Children's Orthopaedic Center at Children's Hospital Los Angeles is the only pediatric program of its kind in Southern California. [More]
Novel drug candidate prevents nerve cell damage in mouse model of Parkinson's disease

Novel drug candidate prevents nerve cell damage in mouse model of Parkinson's disease

A team of scientists at the University of Nebraska Medical Center (UNMC) and Longevity Biotech, Inc., has demonstrated that neuroprotection could be attained in preclinical models by a novel drug candidate that changes immune responses. [More]
Biogen begins ISIS-SOD1 Rx Phase 1/2 clinical study in patients with amyotrophic lateral sclerosis

Biogen begins ISIS-SOD1 Rx Phase 1/2 clinical study in patients with amyotrophic lateral sclerosis

Isis Pharmaceuticals, Inc. today announced that its partner, Biogen, has initiated a Phase 1/2 clinical study of ISIS-SOD1 Rx (BIIB067) in patients with amyotrophic lateral sclerosis (ALS). [More]
Tetra begins human Phase 1 safety trials of BPN14770

Tetra begins human Phase 1 safety trials of BPN14770

Tetra Discovery Partners today announced that the company has initiated human Phase 1 safety trials of its lead compound BPN14770, which Tetra is developing as a potential treatment to both improve memory and slow the progression of Alzheimer's disease. [More]
BRCA1 depletion can potentially contribute to cognitive deficits in Alzheimer's disease

BRCA1 depletion can potentially contribute to cognitive deficits in Alzheimer's disease

Researchers from the Gladstone Institutes have shown for the first time that the protein BRCA1 is required for normal learning and memory and is depleted by Alzheimer's disease. [More]
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