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Isis Pharmaceuticals provides update on ISIS-SMN Rx Phase 2 clinical study in infants with Type I SMA

Isis Pharmaceuticals provides update on ISIS-SMN Rx Phase 2 clinical study in infants with Type I SMA

Isis Pharmaceuticals, Inc. today provided an update on its ongoing open-label Phase 2 clinical study of ISIS-SMN Rx in infants with Type I spinal muscular atrophy (SMA). [More]
Two fragile X proteins play crucial role in proper development of neurons

Two fragile X proteins play crucial role in proper development of neurons

Fragile X syndrome is the most common inherited intellectual disability and the greatest single genetic contributor to autism. Unlocking the mechanisms behind fragile X could make important revelations about the brain. [More]
Study opens door to deeper understanding of genetic, molecular aspects underlying sleep disorders

Study opens door to deeper understanding of genetic, molecular aspects underlying sleep disorders

Washington State University Spokane scientists have grown a tiny group of brain cells that can be induced to fall asleep, wake up and even show rebound sleep after "staying up late." [More]
UC Davis funds BRAIN-STIM program to uncover potential treatments for neurodegenerative disorders

UC Davis funds BRAIN-STIM program to uncover potential treatments for neurodegenerative disorders

In 2013, President Obama announced the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, unveiling plans to make a bold investment to understand the human mind with the intent to uncover ways to prevent, treat and cure brain disorders like Alzheimer's, autism, and epilepsy. [More]
Scientists make breakthrough in schizophrenia research

Scientists make breakthrough in schizophrenia research

An international team of scientists led by Cardiff University researchers has provided the strongest evidence yet of what causes schizophrenia - a condition that affects around 1% of the global population. [More]
Newly discovered nerve cells trigger locomotion, supply the brain with speed-related information

Newly discovered nerve cells trigger locomotion, supply the brain with speed-related information

Scientists at the German Center for Neurodegenerative Diseases and the University of Bonn led by Prof. Stefan Remy report on this in the journal "Neuron". Their investigations give new insights into the workings of spatial memory. Furthermore, they could also help improve our understanding of movement related symptoms associated with Parkinson's disease. [More]
Scientists uncover why some people more prone to major depression

Scientists uncover why some people more prone to major depression

Scientists are beginning to unwrap the biology behind why some people are more prone to major depression and other psychiatric disorders than others when experiencing stressful life events. The researchers found that cellular activity in response to stress hormone receptor activation differs from individual to individual. [More]
New study sheds light on the disruption of astrocytes in depression

New study sheds light on the disruption of astrocytes in depression

A new study published by the team of Naguib Mechawar, Ph.D., a researcher with the McGill Group for Suicide Studies of the Douglas Institute (CIUSSS de l'Ouest-de-l'Ile de Montreal) and associate professor in the Department of Psychiatry at McGill University, sheds new light on the disruption of astrocytes in depression. [More]
Scientists develop human cortical spheroids

Scientists develop human cortical spheroids

A patient tormented by suicidal thoughts gives his psychiatrist a few strands of his hair. She derives stem cells from them to grow budding brain tissue harboring the secrets of his unique illness in a petri dish. She uses the information to genetically engineer a personalized treatment to correct his brain circuit functioning. Just Sci-fi? Yes, but... [More]
RI-MUHC researchers receive $1.5 million to develop glutamate biosensor platform for brain diseases

RI-MUHC researchers receive $1.5 million to develop glutamate biosensor platform for brain diseases

In the human brain and retina, glutamate is an important messenger that carries information from one neuron to another. The level of glutamate transmitted between neurons is crucial to cell communication: too high and neurons die, too low and the information is not communicated properly. In either case this can contribute to neurological diseases including stroke, glaucoma, and Alzheimer's. [More]
Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

CQDM, Brain Canada and the Ontario Brain Institute award close to $8.5M to six (6) multi-disciplinary and multi-provincial research teams across Canada to address unmet needs in neuroscience within their Focus on Brain strategic initiative. To this amount, $1.5M is added from the various research entities involved as in-kind contributions. [More]
Canadian researchers shed light on molecular dynamics of chronic pain

Canadian researchers shed light on molecular dynamics of chronic pain

Chronic pain affects hundreds of millions of people worldwide and is a major cause of disability, causing more disability than cancer and heart disease. Canadian researchers, including Michael Salter at SickKids are shedding light on the molecular dynamics of chronic pain. They have uncovered a critical role for a class of cells present in the brain and spinal cord, called microglia, in pain. [More]
Researchers make important breakthrough in identifying major drivers of excessive coughing

Researchers make important breakthrough in identifying major drivers of excessive coughing

Cough treatments could change dramatically after the herpes virus helped researchers discover that the respiratory tract links to two different parts of the nervous system. [More]

Oscillations could play role in resetting sensitivity of neurons after eye movements

Scientists measuring brain activity have found that in many regions, such as the sensory or motor cortex, activity sometimes oscillates at different frequencies, forming wave-like patterns. Despite the fact that such oscillations are frequently observed, and present in many brain regions, their functional role remains unclear. [More]
New microscopy technique helps researchers to selectively visualize individual cells in living organism

New microscopy technique helps researchers to selectively visualize individual cells in living organism

Researchers at ETH Zurich's Department of Biosystems Science and Engineering in Basel have developed a new microscopy technique that enables for the first time to selectively visualize individual cells within the complex, three-dimensional tissue of a living organism. [More]
UC Irvine study shows youthful vigor can be restored to adult brains

UC Irvine study shows youthful vigor can be restored to adult brains

They say you can't teach an old dog new tricks. The same can be said of the adult brain. Its connections are hard to change, while in children, novel experiences rapidly mold new connections during critical periods of brain development. [More]
Malfunction of brain architecture can prompt neuron to make 'early-career' switch

Malfunction of brain architecture can prompt neuron to make 'early-career' switch

Scientists at the Salk Institute have discovered that the role of neurons -- which are responsible for specific tasks in the brain -- is much more flexible than previously believed. [More]
UT Southwestern testing Vivistim System device in stroke patients

UT Southwestern testing Vivistim System device in stroke patients

UT Southwestern Medical Center will be one of three national sites to pioneer U.S. testing for an implant device that stimulates the vagus nerve in stroke patients to see whether it can help restore lost arm function. [More]

Researchers reconstruct 3D models of neuronal networks for studying cortex organization

Researchers at the Max Planck Institute for Biological Cybernetics (Germany), VU University Amsterdam (Netherlands) and Max Planck Florida Institute for Neuroscience (USA) succeed in reconstructing the neuronal networks that interconnect the elementary units of sensory cortex - cortical columns. [More]
Ground-breaking study characterizes early-stage Alzheimer's abnormalities in the intact brain

Ground-breaking study characterizes early-stage Alzheimer's abnormalities in the intact brain

Alzheimer's disease (AD) is a neurodegenerative condition that strikes at the heart of what makes us human: the ability to think, to feel, to remember and to communicate with those around us. The tragedy is compounded by the fact that there is currently no cure, no treatment, and no diagnostic method capable of identifying Alzheimer's at its early stages. [More]
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