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Scientists discover molecular mechanism responsible for degeneration of Purkinje cells in SCA1

Scientists discover molecular mechanism responsible for degeneration of Purkinje cells in SCA1

Scientists from Bern have discovered a mechanism which is responsible for the degeneration of Purkinje cells in the cerebellum in a neurodegenerative disease called Spinocerebellar ataxia type 1. The results of their study open up new avenues for the future treatment of cerebellum associated degenerative disorders. [More]
Scientists reveal underlying mechanisms that lead to more difficult-to-treat symptoms of schizophrenia

Scientists reveal underlying mechanisms that lead to more difficult-to-treat symptoms of schizophrenia

Scientists at Columbia University's Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University Medical Center, and the Université Paris Descartes have found that deficits in social memory--a crucial yet poorly understood feature of psychiatric disorders such as schizophrenia--may be due to a decrease in the number of a particular class of brain cells, called inhibitory neurons, in a little-explored region within the brain's memory center. [More]
Researchers link idiopathic congenital nystagmus to a defect in neurocomputation

Researchers link idiopathic congenital nystagmus to a defect in neurocomputation

Botond Roska and his group at the Friedrich Miescher Institute for Biomedical Research implicate a clearly defined neuron type and its circuit in the retina in the pathophysiology of idiopathic congenital nystagmus. [More]
Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very expanse of peripheral nerves makes them highly vulnerable to injuries such as blunt-force blows, cuts, and leg and arm fractures, as well as diseases that attack peripheral nerves such as diabetes, Charcot-Marie-Tooth, and Guillain-Barre syndrome. [More]
Alpha-synuclein protein involved in Parkinson's disease pathology does not behave like a 'prion'

Alpha-synuclein protein involved in Parkinson's disease pathology does not behave like a 'prion'

In Parkinson's disease, the protein "alpha-synuclein" aggregates within neurons of patients and appears to propagate across interconnected areas of the brain. How this happens remains largely unknown. [More]
Acute bulbar palsy variant of Guillain-Barré syndrome found

Acute bulbar palsy variant of Guillain-Barré syndrome found

Researchers have identified a new variant form of Guillain-Barré syndrome that is characterised by prominent acute bulbar palsy without neck or limb weakness. [More]
3-D recordings of nematode brains may help understand how neurons coordinate action and perception

3-D recordings of nematode brains may help understand how neurons coordinate action and perception

Princeton University researchers have captured among the first recordings of neural activity in nearly the entire brain of a free-moving animal. The three-dimensional recordings could provide scientists with a better understanding of how neurons coordinate action and perception in animals. [More]
Scientists pin down structure of neuronal protein clumps associated with ALS

Scientists pin down structure of neuronal protein clumps associated with ALS

To create treatments for a disease without any, scientists need to study and understand the driving forces behind the faulty biology. Today, researchers at the University of North Carolina School of Medicine announced the first-ever evidence-based description of the neuronal protein clumps thought to be important in Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, a fatal neurodegenerative condition. [More]
Ultrafast near-infrared lasers deliver gene therapy to treat macular degeneration

Ultrafast near-infrared lasers deliver gene therapy to treat macular degeneration

Millions of adults over age 50 struggle each year with vision loss caused by damage to the retina or common macular degeneration. [More]
Researchers describe epigenetic mechanisms underlying the development of cerebellum

Researchers describe epigenetic mechanisms underlying the development of cerebellum

From before birth through childhood, connections form between neurons in the brain, ultimately making us who we are. So far, scientists have gained a relatively good understanding of how neural circuits become established, but they know less about the genetic control at play during this crucial developmental process. [More]
Salk researchers move one step closer to unlocking how the brain functions

Salk researchers move one step closer to unlocking how the brain functions

How the brain functions is still a black box: scientists aren't even sure how many kinds of nerve cells exist in the brain. To know how the brain works, they need to know not only what types of nerve cells exist, but also how they work together. Researchers at the Salk Institute have gotten one step closer to unlocking this black box. [More]
Understanding how thought arises from brain structure

Understanding how thought arises from brain structure

Using 20 years of functional magnetic resonance imaging (fMRI) data from tens of thousands of brain imaging experiments, computational neuroscientists Hava Siegelmann and a postdoctoral colleague at the University of Massachusetts have created a geometry-based method for massive data analysis to reach a new understanding of how thought arises from brain structure. [More]
Researchers identify dazzling new method for visualizing neurons

Researchers identify dazzling new method for visualizing neurons

Researchers have discovered a dazzling new method of visualizing neurons that promises to benefit neuroscientists and cell biologists alike: by using spectral confocal microscopy to image tissues impregnated with silver or gold. [More]
Genes vital for age-related cognitive declines in memory identified in adult worm neurons

Genes vital for age-related cognitive declines in memory identified in adult worm neurons

Researchers from Princeton University have identified genes important for age-related cognitive declines in memory in adult worm neurons, which had not been studied previously. The research, published in the journal Nature, could eventually point the way toward therapies to extend life and enhance health in aging human populations. [More]
Light-driven protein has potential to become key tool for optogenetics

Light-driven protein has potential to become key tool for optogenetics

Biophysicists have developed a hypothesis to explain the function of a light-driven protein which pumps sodium ions across a cell membrane, and they have revealed the key structural feature of these pumps. The scientists see these sodium pumps as being highly promising tools in using light signals to control nerve cells – which is exactly what is involved in the new scientific field of optogenetics. [More]
Researchers trace origins of early abnormal brain overgrowth in ASD

Researchers trace origins of early abnormal brain overgrowth in ASD

Further underscoring the prenatal origins of Autism Spectrum Disorder (ASD), researchers at University of California, San Diego School of Medicine describe for the first time how abnormal gene activity in cell cycle networks that are known to control brain cell production may underlie abnormal early brain growth in the disorder. [More]
Report uncovers how Down syndrome hampers nervous system that plays key role in health, longevity

Report uncovers how Down syndrome hampers nervous system that plays key role in health, longevity

While most Down syndrome research has focused on the brain, a new report by Johns Hopkins University biologists uncovers how the disorder hampers a separate part of the nervous system that plays a key role in health and longevity. [More]
Androgen deprivation therapy elevates Alzheimer’s risk

Androgen deprivation therapy elevates Alzheimer’s risk

US researchers find that androgen deprivation therapy increases the risk of Alzheimer’s disease in men with prostate cancer, with the risk rising with greater duration of therapy. [More]
Apigenin improves neuron formation, strengthens connections between brain cells

Apigenin improves neuron formation, strengthens connections between brain cells

Brazilian researchers from D'Or Institute for Research and Education, Federal University of Rio de Janeiro and Federal University of Bahia have demonstrated in laboratory that apigenin, a substance found in parsley, thyme, chamomile and red pepper, improves neuron formation and strengthens the connections between brain cells. [More]
Shank3 gene linked to both autism and schizophrenia

Shank3 gene linked to both autism and schizophrenia

Although it is known that psychiatric disorders have a strong genetic component, untangling the web of genes contributing to each disease is a daunting task. Scientists have found hundreds of genes that are mutated in patients with disorders such as autism, but each patient usually has only a handful of these variations. [More]
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