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New class of compounds protect brain cells from traumatic brain injury

New class of compounds protect brain cells from traumatic brain injury

A new class of compounds has now been shown to protect brain cells from the type of damage caused by blast-mediated traumatic brain injury (TBI). [More]
Mice who have partial deficiency of gene SENP2 are more likely to develop seizures, sudden death

Mice who have partial deficiency of gene SENP2 are more likely to develop seizures, sudden death

A gene crucial for brain and heart development may also be associated with sudden unexplained death in epilepsy (SUDEP), the most common cause of early mortality in epilepsy patients. [More]
Neuroscientist discovers new mechanism that can reverse chronic pain

Neuroscientist discovers new mechanism that can reverse chronic pain

It's in the brain where we perceive the unpleasant sensations of pain, and researchers have long been examining how calcium channels in the brain and peripheral nervous system contribute to the development of chronic pain conditions. [More]
Using iPS technology researchers develop new therapies for Parkinson's disease and ALS

Using iPS technology researchers develop new therapies for Parkinson's disease and ALS

Dresden. Dr. Jared Sterneckert is entering the research area "Neurodegenerative Diseases" of the DFG Research Center and Cluster of Excellence at the TU Dresden as a new junior group leader. Since 2006, he has led a team working at the "Max Planck Institute for Molecular Biomedicine" in Münster to develop models of Parkinson's disease and amyotrophic lateral sclerosis. [More]
Flow through pain-sensing molecule helps worms adapt to pain

Flow through pain-sensing molecule helps worms adapt to pain

When you accidentally touch a hot oven, you rapidly pull your hand away. Although scientists know the basic neural circuits involved in sensing and responding to such painful stimuli, they are still sorting out the molecular players. [More]
Scientists develop synthetic amino acid that can impact 3D structure of bioactive peptides

Scientists develop synthetic amino acid that can impact 3D structure of bioactive peptides

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side-effects to the patient. Such properties are directly related to the 3D structure of the drug molecule. [More]
Researchers reveal how distinct areas of frontal lobes are critical for person's ability to learn

Researchers reveal how distinct areas of frontal lobes are critical for person's ability to learn

Until the last few decades, the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function-hence the frequent use of lobotomies in the early 20th century to treat psychiatric disorders. [More]
Scientists find that lack of naturally occurring protein linked to early signs of dementia

Scientists find that lack of naturally occurring protein linked to early signs of dementia

Scientists at the University of Warwick have provided the first evidence that the lack of a naturally occurring protein is linked to early signs of dementia. [More]
New mouse model to open door to research on epilepsy, Alzheimer's

New mouse model to open door to research on epilepsy, Alzheimer's

University of Utah scientists have developed a genetically engineered line of mice that is expected to open the door to new research on epilepsy, Alzheimer's and other diseases. [More]
Understanding neuron development: an interview with Dr. Brock Grill, The Scripps Research Institute

Understanding neuron development: an interview with Dr. Brock Grill, The Scripps Research Institute

There’s a big difference between understanding coordination and actually building connectivity. In terms of building connectivity, several molecules have been identified that control this process and a lot has been learned from both genetic and biochemical research in a variety of different systems, particularly studies in the nematode C. elegans, the fruit fly Drosophila and mice. [More]
Children and adolescents with autism have surplus of synapses in brain

Children and adolescents with autism have surplus of synapses in brain

Children and adolescents with autism have a surplus of synapses in the brain, and this excess is due to a slowdown in a normal brain "pruning" process during development, according to a study by neuroscientists at Columbia University Medical Center (CUMC). [More]
Researchers uncover reasons for decreasing sleep quality as we age

Researchers uncover reasons for decreasing sleep quality as we age

Researchers from the United States have shed light on why people experience more fragmented sleep as they grow older. [More]
Researchers uncover role of epigenetic changes in Alzheimer's disease

Researchers uncover role of epigenetic changes in Alzheimer's disease

A team led by researchers at the University of Exeter Medical School and King's College London has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer's disease. [More]
New therapeutic strategy to combat common genetic risk factor for ALS, FTD

New therapeutic strategy to combat common genetic risk factor for ALS, FTD

A team of researchers at Mayo Clinic and The Scripps Research Institute in Florida have developed a new therapeutic strategy to combat the most common genetic risk factor for the neurodegenerative disorders amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD). [More]
Huntingtin protein plays critical role in long-term memory development

Huntingtin protein plays critical role in long-term memory development

It has been more than 20 years since scientists discovered that mutations in the gene huntingtin cause the devastating progressive neurological condition Huntington's disease, which involves involuntary movements, emotional disturbance and cognitive impairment. [More]
Bioengineers create 3D brain-like tissue to study chemical and electrical changes

Bioengineers create 3D brain-like tissue to study chemical and electrical changes

Bioengineers have created three-dimensional brain-like tissue that functions like and has structural features similar to tissue in the rat brain and that can be kept alive in the lab for more than two months. [More]
Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia? [More]
Neurons derived from human iPSC and grafted into rats after spinal cord injury produce cells

Neurons derived from human iPSC and grafted into rats after spinal cord injury produce cells

Building upon previous research, scientists at the University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSC) and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals' central nervous system. [More]
Molecule Notch involved in fear memory formation

Molecule Notch involved in fear memory formation

Nature is thrifty. The same signals that embryonic cells use to decide whether to become nerves, skin or bone come into play again when adult animals are learning whether to become afraid. [More]
Researchers take major step forward in developing real ALS treatments

Researchers take major step forward in developing real ALS treatments

A series of studies begun by Harvard Stem Cell Institute scientists eight years ago has lead to a report published today that may be a major step forward in the quest to develop real treatments for amyotrophic lateral sclerosis, ALS, or Lou Gehrig's disease. [More]