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Neuropathic pain is a type of pain that is caused by damage to the nervous system following an injury or illness and affects approximately 1% of the population.
Fruit flies can be powerful model for unraveling cellular, molecular bases of damaging cold perception

Fruit flies can be powerful model for unraveling cellular, molecular bases of damaging cold perception

The tiny fruit fly can help humans investigate the genetic and neural bases of detecting painful or harmful cold stimuli and offer intriguing, potential implications for human health, according to a new study. [More]
Six pioneering French companies to exhibit in innovation zone at Medica 2016

Six pioneering French companies to exhibit in innovation zone at Medica 2016

In a global market worth almost €200 billion (around £173 billion) a year, the medical devices and in vitro diagnostics sector is particularly innovative in France. Across the Channel, the sector is comprised of over a thousand companies, employing almost 65,000 people with expertise encompassing medicine, mechanics, material physics and digital technologies. [More]
New drug appears to decrease inflammation in the brain linked to Alzheimer's disease

New drug appears to decrease inflammation in the brain linked to Alzheimer's disease

An experimental drug shows promise in treating Alzheimer's disease by preventing inflammation and removing abnormal protein clumps in the brain that are associated with the disease, suggests a study in mice presented at the ANESTHESIOLOGY 2016 annual meeting. [More]
U-M investigators awarded $7.5 million NIH grant to expand chronic pain research

U-M investigators awarded $7.5 million NIH grant to expand chronic pain research

In order to better understand the disparity between identifiable damage and chronic pain, the National Institutes of Health has awarded $7.5 million over five years to physician-scientists at the University of Michigan Health System. [More]
UC Irvine study shows how YHS effectively treats different forms of pain

UC Irvine study shows how YHS effectively treats different forms of pain

Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms. [More]
Study finds South Africans living with HIV more resilient despite chronic pain

Study finds South Africans living with HIV more resilient despite chronic pain

When one thinks about chronic conditions that are commonly painful, HIV doesn't typically spring to mind. However, more than 50% of HIV-positive individuals experience a painful condition like headache, chest pain or neuropathy, and that pain is frequently experienced as moderate to severe in intensity. [More]
Research provides insight into link between chronic pain and anxiety

Research provides insight into link between chronic pain and anxiety

New research provides insight into a long-observed, but little-understood connection between chronic pain and anxiety and offers a potential target for treatment. [More]
Special review highlights benefits of using botulinum neurotoxin for treating facial wrinkles

Special review highlights benefits of using botulinum neurotoxin for treating facial wrinkles

Botox and other botulinum neurotoxin (BoNT) products are widely known for their use in treating facial wrinkles--but they can also be used to treat a wide range of non-cosmetic problems. [More]
Study results confirm safety and efficacy of INSIGHTEC’s Exablate Neuro system for the  treatment of essential tremor

Study results confirm safety and efficacy of INSIGHTEC’s Exablate Neuro system for the treatment of essential tremor

INSIGHTEC, the leader in MR-guided Focused Ultrasound (MRgFUS) therapy, has announced that the New England Journal of Medicine (NEJM) has published the results of a pivotal study of their Exablate Neuro system for the non-invasive treatment of essential tremor (ET). The study met its primary endpoint with patients treated with Exablate Neuro demonstrating a clinically significant 47% improvement in a composite tremor score at three months as compared to no change in the sham cohort. [More]
DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons. [More]
Neuropathic pain could be significantly reduced by targeting brain cells

Neuropathic pain could be significantly reduced by targeting brain cells

Neuropathic pain - which affects more than 1 million Americans - could be reduced or even eliminated by targeting brain cells that are supposed to provide immunity but, in some instances, do the opposite, causing chronic pain that could last a lifetime. [More]
Researchers develop first clinical practice guidelines for managing pain after spinal cord injury

Researchers develop first clinical practice guidelines for managing pain after spinal cord injury

Researchers at Lawson Health Research Institute are the first in Canada to develop clinical practice guidelines for managing neuropathic pain with patients who have experienced a spinal cord injury (SCI). [More]
Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic pain after spinal cord injury. The findings are published in the Journal of Orthopaedic Research. [More]
IU researchers identify suite of genes that play role in nerve sensitivity

IU researchers identify suite of genes that play role in nerve sensitivity

Indiana University researchers have that found a suite of genes in both fruit flies and humans -- including one dubbed "smoke alarm" -- plays a role in nerve sensitivity. The study could help lead to new drug targets in pain management. [More]
Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Chronic pain is one of the most prevalent, disabling and expensive public health crises in the United States. It affects more than 100 million Americans, with annual costs estimated at $635 billion, says a 2014 report from the American Pain Society. [More]
Nonopioid interventional options for chronic pain not covered by insurance in few U.S. states

Nonopioid interventional options for chronic pain not covered by insurance in few U.S. states

Recent studies have shown significant therapeutic value from the use of high-frequency - 10,000 (HF-10) spinal cord stimulation (SCS) for patients experiencing chronic back and leg pain. [More]
Maternal pregabalin exposure linked to major birth defect risk

Maternal pregabalin exposure linked to major birth defect risk

First trimester exposure to pregabalin may be associated with an increased risk of major birth defects, an observational study suggests. [More]
Taking pregabalin drug during pregnancy could lead to major birth defects

Taking pregabalin drug during pregnancy could lead to major birth defects

A drug commonly used to treat pain, epilepsy, anxiety and other brain health disorders may be associated with an increased risk of major birth defects, according to a study published in the May 18, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Gene therapy could be potential treatment for neuropathic pain in cancer patients

Gene therapy could be potential treatment for neuropathic pain in cancer patients

A study providing new information about neuropathic pain afflicting some 90 percent of cancer patients who have had nerve damage caused by tumors, surgery, chemotherapy or radiation indicates gene therapy as a possible treatment. [More]
Scientists discover CD2AP protein that plays key role in nervous system

Scientists discover CD2AP protein that plays key role in nervous system

University of Louisville researchers have discovered that a protein previously known for its role in kidney function also plays a significant role in the nervous system. In an article featured in the April 13 issue of the Journal of Neuroscience, they show that the adaptor protein CD2AP is a key player in a type of neural growth known as collateral sprouting. [More]
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