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Neurons in remote brain regions drive glioblastoma infiltration

Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Despite treatment, GBM recurrence is inevitable and tends to occur outside surgical margins or in locations remote to the primary tumor, highlighting the central role played by tumor infiltration in this malicious disease.

28 Jun 2023

New effort minimizes surgeon-specific standardized infection ratio

When excess surgical site infections (SSIs) were detected among neurosurgery patients at University of Pittsburgh Medical Center (UPMC) Mercy in 2019, infection preventionist Katie Palladino, MPH, CPH, CIC, partnered with a hospital neurosurgeon on a multidisciplinary quality and process improvement initiative that led to a steep drop in infection rates over a two-year period. Their successful initiative is being presented at the Association for Professionals in Infection Control and Epidemiology's (APIC's) Annual Conference in Orlando Florida, June 26-28.

26 Jun 2023

Gestational diabetes influences diabetes risk and blood sugar control

People who develop diabetes following pregnancy were significantly less likely to be able to bring it under control if they had experienced gestational diabetes during their pregnancy, especially if they were Black or Hispanic, according to a Mount Sinai study published on June 21 in the journal Diabetes Care.

21 Jun 2023

Researchers identify Paenibacillus bacteria as responsible for postinfectious hydrocephalus in Uganda

In 2007, Yale pediatric neurosurgeon Steven Schiff, MD, visited his friend, Benjamin Warf, MD, at the CURE Children's Hospital of Uganda.

20 Jun 2023

New approach improves diagnosis of limb-girdle muscular dystrophy

It's not easy to distinguish between the dozens of subtypes of limb girdle muscular dystrophy -; a rare, genetic muscle disease characterized by weakness in the hips and shoulders that causes difficulty walking and lifting the arms.

15 Jun 2023

Study reveals sharp increase in hospital encounters for benzodiazepine-related toxicity among youth

The rate of hospital encounters for benzodiazepine-related toxicity rose by 67 per cent for young adults (aged 19 to 24) and 44 per cent for youth (aged 18 or below) in Ontario between 2013 and 2020, according to a new study from ICES and Unity Health Toronto.

15 Jun 2023

New study may help improve diagnosis of cognitive disability in Parkinson's disease

A few minutes of data recorded from a single electrode placed on top of the head may be sufficient to predict thinking problems, including dementia, in patients with Parkinson's disease (PD).

12 Jun 2023

Study may help advance data on oncolytic adenovirus mediated double suicide-gene therapy for high-grade brain tumors

Researchers in the Hermelin Brain Tumor Center at Henry Ford Health are leading a Phase I clinical trial studying the maximum tolerated dose of an oncolytic adenovirus, a mutated virus engineered to selectively replicate in and destroy cancer tissue, in combination with fractionated stereotactic radiosurgery among patients who are undergoing resection of a recurrent high-grade astrocytoma brain tumor.

8 Jun 2023

Life-changing procedure using new aortic valve device clears way for patient in need of liver transplant and hip replacement

Janice Couch, 62, a retired pre-school teacher from Grand Rapids, Michigan, is finally physically ready to receive two procedures that stand to change her life, thanks to Henry Ford Health interventional cardiologists who paved the way by implanting a new aortic valve device for the first time in the health system's history.

6 Jun 2023

Therapeutic nanocarriers engineered from adult skin cells show promise for treating lung injury

Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.

6 Jun 2023

Hispanic births with neural tube defects not significantly reduced after voluntary folic acid fortification of corn masa flour

The US Food and Drug Administration (FDA) mandated folic acid fortification of all enriched cereal grains in 1996, and this regulation resulted in a reduction of neural tube defect (NTD)–affected pregnancies for the population in the United States.

2 Jun 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Largest clinical case series of laughing gas users finds a predominance of young Asian men

The largest clinical case series to date of recreational users of nitrous oxide, popularly known as laughing gas, has found a predominance of young men of Asian ethnicity among those with neurological side effects who were seen at hospitals in 3 major cities in England.

30 May 2023

New blood biomarkers can help quantify the brain impact of neurosurgery

Damage to the brains of patients operated on for brain tumors may be assessed by measuring biomarkers in the blood pre- and postoperatively.

30 May 2023

Mays Cancer Center conducts clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma

The Mays Cancer Center at The University of Texas Health Science Center at San Antonio recently conducted a clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma (GBM).

24 May 2023

Regular exercise may reduce bleeding in individuals with intracerebral hemorrhage

Regular physical activity and exercise may reduce bleeding in individuals with intracerebral hemorrhage, a University of Gothenburg study shows.

22 May 2023

Blood vessel abnormalities in the eye could drive Alzheimer's disease

Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer's disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

22 May 2023

Study examines safety and efficacy of made-to-fade tattoos for medical markings

Researchers at Henry Ford Health -; one of the nation's leading integrated academic medical institutions -; in collaboration with Ephemeral Tattoo, have conducted a study on the safety and efficacy of made-to-fade tattoos for medical markings.

17 May 2023

Bioresorbable vascular scaffolds may be just as effective as drug-eluting metal stents for treating heart disease patients

First-generation bioresorbable vascular scaffolds (BVS) may be just as effective as drug-eluting metallic stents, which are currently the standard treatment for heart disease patients undergoing percutaneous coronary intervention (PCI).