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Commonly known as the "silent killer," ovarian cancer leads to approximately 15,000 deaths each year in the United States, according to the American Cancer Society. Approximately 20,000 new cases are diagnosed each year, with the majority in patients diagnosed with late stage disease where the cancer has spread beyond the ovary. The prognosis is poor in these patients, leading to the high mortality from this disease. A diagnostic test is needed that can provide adequate predictive value to stratify patients with a pelvic mass into high risk of invasive ovarian cancer versus those with low risk, as well as a screening test for the diagnosis of early-stage ovarian cancer, which is essential for improving overall survival in patients. Ovarian cancer has up to a 90% cure rate following surgery and/or chemotherapy if detected in stage 1.
Researchers develop tiny 3-D tissue models to study how ovarian cancer develops in women

Researchers develop tiny 3-D tissue models to study how ovarian cancer develops in women

With a unique approach that draws on 3-D printing technologies, a team of University of Wisconsin-Madison researchers is developing new tools for understanding how ovarian cancer develops in women. [More]
Study uncovers new drug-gene mutation combinations that can kill cancer cells

Study uncovers new drug-gene mutation combinations that can kill cancer cells

In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. [More]
Scientists find promising new method to detect and treat recurrence of ovarian cancer

Scientists find promising new method to detect and treat recurrence of ovarian cancer

Researchers at the Mayo Clinic Center for Individualized Medicine have found a promising new way to monitor and treat recurrence of ovarian cancer -- a hard-to-detect disease that claims many lives. [More]
New streamlined approach to genetic testing benefits women with ovarian cancer

New streamlined approach to genetic testing benefits women with ovarian cancer

A new streamlined approach to genetic testing for women with ovarian cancer provides testing rapidly and affordably, allowing many more patients to benefit from personalised cancer management and their relatives to benefit from cancer prevention strategies. [More]
Study shows feasibility to adopt salpingectomy in large scale clinical practice without surgical repercussions

Study shows feasibility to adopt salpingectomy in large scale clinical practice without surgical repercussions

A surgical procedure recommended to reduce the future risk of ovarian cancer has been successfully implemented throughout Kaiser Permanente in Northern California without a change in surgical outcomes, according to research published today in the journal Obstetrics & Gynecology. [More]
Researchers discover new signaling events that trigger metastasis in ovarian cancer cells

Researchers discover new signaling events that trigger metastasis in ovarian cancer cells

Like pancreatic cancer, cancer of the ovaries is notorious for being discovered at a relatively late stage - after it has spread to other sites in the body. It is not called "the silent killer" for nothing. [More]
Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Inherited mutations in genes that function to repair DNA may contribute to metastatic prostate cancer more than previously recognized, according to a study out today in the New England Journal of Medicine. [More]
Women with BRCA1 gene mutation at increased risk of aggressive uterine cancer

Women with BRCA1 gene mutation at increased risk of aggressive uterine cancer

Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher. [More]
Online information can increase feelings of worry and fear among women at risk of ovarian cancer

Online information can increase feelings of worry and fear among women at risk of ovarian cancer

Researchers at Cardiff University have found that online information about ovarian cancer can cause as much worry as comfort for women at high risk of developing the disease, in a new study published in ecancer. [More]
Study focuses on critical proteins involved in ovarian cancer biology

Study focuses on critical proteins involved in ovarian cancer biology

In what is believed to be the largest study of its kind, scientists at the Pacific Northwest National Laboratory, Johns Hopkins University and their collaborators from institutions across the nation have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors. [More]
Home test using paper strips could help detect cancer, malaria

Home test using paper strips could help detect cancer, malaria

What if testing yourself for cancer or other diseases were as easy as testing your blood sugar or taking a home pregnancy test? In a few years, it might be. [More]
Study examines role of HOX genes in ovarian cancer resistance

Study examines role of HOX genes in ovarian cancer resistance

A new UK study has identified a gene signature that predicts poor survival from ovarian cancer. The study also identified genes which help the cancer develop resistance to chemotherapy - offering a new route to help tackle the disease. [More]
Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Vice President Biden and Dr. Jill Biden will host a Cancer Moonshot Summit in Washington, D.C. at the White House. Cheryl Willman, MD, Director and CEO of The University of New Mexico Comprehensive Cancer Center, will attend. [More]
Telephone counseling can help make cancer genetic services more accessible to rural women

Telephone counseling can help make cancer genetic services more accessible to rural women

Ever since Angelina Jolie used cancer genetic counseling and testing to learn about her risk for hereditary breast and ovarian cancer, many other women have chosen to do the same. [More]
Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Patients with an advanced disease often relapse due to the development of chemoresistance. Chemotherapy failure is a consequence of acquired drug resistance which may potentially be due to multiple mechanisms including miRNA-mediated gene regulation. [More]
Diet modification could help improve quality of life in women with ovarian cancer

Diet modification could help improve quality of life in women with ovarian cancer

New research conducted at the University of Alabama at Birmingham has shown that a particular type of diet could help women with ovarian cancer to lose weight and improve their quality of life and cancer-related measures. [More]
Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

A newly devised tumor-specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery. [More]
Already-approved drugs can fight apoptosis evasion in cancer

Already-approved drugs can fight apoptosis evasion in cancer

Cancer cells don't die when they're supposed to. Animal and human bodies follow an orderly process of birthing new cells and killing old ones. But cancer cells escape programmed cell death, called apoptosis, and multiply uncontrollably. [More]
Immunotherapy drugs given after chemotherapy may benefit ovarian cancer patients

Immunotherapy drugs given after chemotherapy may benefit ovarian cancer patients

Women with advanced ovarian cancer may benefit more from immunotherapy drug treatments if they are given straight after chemotherapy, according to a new study published in Clinical Cancer Research today. [More]
Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

They're inside our gut, on the skin, and in the mouth. Thousands of different types of micro-organisms live in and on the body, playing helpful roles in digestion or in aiding the body's natural defense system. [More]
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