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Imaging biomarker proposed for Parkinson’s disease

Imaging biomarker proposed for Parkinson’s disease

Reduced off-medication connectivity in the basal ganglia network separates patients with early Parkinson’s disease from healthy controls with high accuracy, preliminary findings suggest. [More]
Cardiac stress test findings normal in premotor Parkinson’s disease patients

Cardiac stress test findings normal in premotor Parkinson’s disease patients

People who go on to develop Parkinson’s disease do not perform significantly differently from normal controls on exercise stress testing, an Israeli study has found. [More]
Low accuracy of clinical diagnosis for early Parkinson’s disease

Low accuracy of clinical diagnosis for early Parkinson’s disease

About three-quarters of patients suspected to have early Parkinson’s disease eventually prove to have other conditions, a study shows. [More]
Scientists one step closer to understanding the causes of Parkinson's disease

Scientists one step closer to understanding the causes of Parkinson's disease

Scientists have taken a step closer to understanding the causes of Parkinson's disease, identifying what's happening at a cellular level to potentially help develop future treatments. [More]
DBS improves motor and non motor symptoms of patients with early Parkinson's disease

DBS improves motor and non motor symptoms of patients with early Parkinson's disease

Deep brain stimulation (DBS) has become a well-recognized non-pharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson's disease. [More]
Scientists use femtosecond lasers to tackle Parkinson's disease

Scientists use femtosecond lasers to tackle Parkinson's disease

Scientists are combining physics and neurobiology to tackle Parkinson's disease. The Okinawa Institute of Science and Technology Graduate University's Femtosecond Spectroscopy Unit and Neurobiology Research Unit, along with collaborators at the University of Otago, New Zealand are using lasers, nanotechnology and neuroscience to develop a new, versatile drug delivery system. [More]
Failing dopamine pump damages brain cells of patients with Parkinson's disease

Failing dopamine pump damages brain cells of patients with Parkinson's disease

A study group at the Medical University of Vienna's Centre for Brain Research has investigated the function of an intracellular dopamine pump in Parkinson's patients compared to a healthy test group. [More]
Increase in protein helps store dopamine and protects from Parkinson's disease

Increase in protein helps store dopamine and protects from Parkinson's disease

Researchers from Emory's Rollins School of Public Health discovered that an increase in the protein that helps store dopamine, a critical brain chemical, led to enhanced dopamine neurotransmission and protection from a Parkinson's disease-related neurotoxin in mice. [More]
Combination of effective drugs for Parkinson's disease controls symptoms of Rett syndrome in mice

Combination of effective drugs for Parkinson's disease controls symptoms of Rett syndrome in mice

IDIBELL researchers, led by the director of the Program for Epigenetics and Cancer Biology, ICREA researcher and Professor of Genetics at the University of Barcelona, Manel Esteller, have shown that a combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease. [More]
PD MED trial: Levodopa drug better for long-term treatment of newly diagnosed PD

PD MED trial: Levodopa drug better for long-term treatment of newly diagnosed PD

For long-term treatment of newly diagnosed Parkinson’s disease (PD), the old drug levodopa provides better mobility and a higher quality of life than the two main alternatives, dopamine agonists (DA) and monoamine oxidase type B inhibitors (MAOBI), according to the largest-ever trial of PD treatment (PD MED), published in The Lancet. [More]
Study heterogeneity hinders mortality predictions in Parkinson’s disease

Study heterogeneity hinders mortality predictions in Parkinson’s disease

Poor study quality and heterogeneity in study methods and patients make it difficult to determine the impact Parkinson’s disease has on mortality, UK researchers report. [More]

Dopamine transporter availability predicts ICDs

Reduced striatal dopamine transporter availability is already present in patients with Parkinson’s disease who go on to develop impulse control disorders, a study shows. [More]
New gene involved in Parkinson's disease, find researchers

New gene involved in Parkinson's disease, find researchers

A team of UCLA researchers has identified a new gene involved in Parkinson's disease, a finding that may one day provide a target for a new drug to prevent and potentially even cure the debilitating neurological disorder. [More]
Study warns against use of resveratrol supplements by pregnant women

Study warns against use of resveratrol supplements by pregnant women

A widely available dietary supplement that had been considered safe - and that some claim provides anti-aging and other health benefits - caused significant developmental abnormalities in the pancreas of offspring of pregnant monkeys who were given the supplement, according to a study published today in the FASEB Journal, from the Federation of American Societies of Experimental Biology. [More]

Scan may rule out Parkinson’s disease

Patients with clinical symptoms of early Parkinson’s disease but no evidence of dopaminergic deficit on brain imaging are unlikely to have the condition, say the PRECEPT Study investigators. [More]
Presynaptic dopaminergic lesion predicts drug-induced dyskinesia

Presynaptic dopaminergic lesion predicts drug-induced dyskinesia

Research suggests that the extent of presynaptic dopaminergic denervation before starting therapy may predict which patients with Parkinson’s disease will later develop levodopa-induced dyskinesia. [More]
Researchers develop potential route to new therapies for treatment of Parkinson's disease

Researchers develop potential route to new therapies for treatment of Parkinson's disease

A biologist and a psychologist at the University of York have joined forces with a drug discovery group at Lundbeck in Denmark to develop a potential route to new therapies for the treatment of Parkinson's Disease (PD). [More]

‘Lessebo’ effect implications for Parkinson’s therapies

Patients with Parkinson’s disease have a reduced objective response to treatment given in a clinical trial if they know they may be taking a placebo, research shows. [More]
Patients with Parkinson's disease show improvements after exenatide therapy

Patients with Parkinson's disease show improvements after exenatide therapy

Follow-Up Study Published in the Journal of Parkinson's Disease Supports an Earlier "Proof of Concept" Trial. A follow-up study of patients with Parkinson's disease (PD) who participated in an earlier "proof of concept" clinical trial using exenatide showed that improvements persisted twelve months after discontinuing exenatide therapy. [More]

Compound Formula Rehmannia reduces levodopa-induced dyskinesia in Parkinson's disease

Levodopa is the preferred treatment for Parkinson's disease in the clinic. However, long-term use of levodopa may lead to various motor complications, among which levodopa-induced dyskinesia is the most common, severely affecting patients' quality of life. [More]