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GLNT to use $1.5M NIH award to expand Parkinson’s monitoring technology to mobile apps

GLNT to use $1.5M NIH award to expand Parkinson’s monitoring technology to mobile apps

Great Lakes NeuroTechnologies announced today they will be using a $1.5M award from NIH to expand their Parkinson’s monitoring technology to mobile applications. Repositioning GLNT’s Kinesia product line with mobile apps strategically aligns with growing trends in domestic and international healthcare landscapes regarding accessibility, costs, reimbursement, and regulatory policies. [More]

Domain Therapeutics receives grant to support development of mGluR3 PAM for Parkinson’s disease

Domain Therapeutics, a biopharmaceutical company specializing in the research and development of new drug candidates targeting G protein-coupled receptors (GPCRs), today announces the receipt of a second grant of 230 000 dollars (USD) from The Michael J. Fox Foundation for Parkinson’s Research to support its metabotropic glutamate receptor type III (mGluR3) positive allosteric modulators (PAM) program. [More]
Electrode placement affects subthalamic nucleus stimulation outcomes

Electrode placement affects subthalamic nucleus stimulation outcomes

Researchers have identified factors associated with motor, cognitive and mood outcomes after deep-brain stimulation (DBS) of the subthalamic nucleus in a large cohort of patients with Parkinson’s disease. [More]
Mechanism for pesticide effect on PD risk uncovered

Mechanism for pesticide effect on PD risk uncovered

Some pesticides may contribute to Parkinson’s disease risk by inhibiting neuronal aldehyde dehydrogenase activity, a study suggests. [More]
Salivary gland biopsy could confirm PD in the living

Salivary gland biopsy could confirm PD in the living

Biopsy of the submandibular gland could confirm the presence of Parkinson’s disease (PD) in living patients with clinical symptoms, research suggests. [More]

Circadian dysfunction blamed for sleepiness in PD patients

Patients with Parkinson’s disease, particularly those with excessive daytime sleepiness, have reduced melatonin levels and amplitude of the melatonin circadian rhythm, research shows. [More]

GLNT receives allowance of patent for Parkinson's disease monitoring technology

Great Lakes NeuroTechnologies announced today they have received a new allowance of claims from the U.S. Patent Office, the company’s fourth in the past eight months focused on technology for Parkinson’s disease diagnostics and treatment. [More]
Prions and their shadow proteins: an interview with Dr Jiri Safar, Co-Director of the National Prion Disease Pathology Surveillance Center

Prions and their shadow proteins: an interview with Dr Jiri Safar, Co-Director of the National Prion Disease Pathology Surveillance Center

The prion diseases were originally discovered by Dr Gajdusek and Dr Gibbs. The first disease discovered was Kuru, which was affecting native tribes in the Papua New Guinea highlands in the 1950s. [More]

Great Lakes NeuroTechnologies receives another patent for Parkinson’s disease monitoring technology

Great Lakes NeuroTechnologies announced today they have received another allowance of claims from the U.S. Patent Office. The application covers a system and method of controlling Parkinson's therapy in response to motor symptoms. [More]
Study shows how pesticides may contribute to development of Parkinson's disease

Study shows how pesticides may contribute to development of Parkinson's disease

New research shows how pesticides may increase the risk of Parkinson's disease and that people with certain gene variants may be more susceptible to the disease. The research is published in the February 4, 2014, print issue of Neurology®, the medical journal of the American Academy of Neurology. [More]
Researchers discover mechanism that controls activity of LRRK2 in Parkinson's disease

Researchers discover mechanism that controls activity of LRRK2 in Parkinson's disease

In one variant of Parkinson's disease, the enzyme LRRK2 plays a central role. Scientists at the University of Kassel have now discovered a mechanism that controls the activity of LRRK2. [More]
Continuing spinal cord stimulation improves symptoms of Parkinson's disease

Continuing spinal cord stimulation improves symptoms of Parkinson's disease

Researchers at Duke Medicine have shown that continuing spinal cord stimulation appears to produce improvements in symptoms of Parkinson's disease, and may protect critical neurons from injury or deterioration. [More]
Johns Hopkins researchers reveal how calcium is controlled in the body

Johns Hopkins researchers reveal how calcium is controlled in the body

Scientists at Johns Hopkins report they have figured out a key step in how “free” calcium — the kind not contained in bones — is managed in the body, a finding that could aid in the development of new treatments for a variety of neurological disorders that include Parkinson’s disease. [More]
People with higher levels of omega-3 fatty acids may have larger brain volumes in old age

People with higher levels of omega-3 fatty acids may have larger brain volumes in old age

People with higher levels of the omega-3 fatty acids found in fish oil may also have larger brain volumes in old age equivalent to preserving one to two years of brain health, according to a study published in the January 22, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology. Shrinking brain volume is a sign of Alzheimer's disease as well as normal aging. [More]
TSRI study shows how aging affects brain's neural circuitry

TSRI study shows how aging affects brain's neural circuitry

How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease. [More]
Gene therapy edges closer for Parkinson’s disease

Gene therapy edges closer for Parkinson’s disease

Lentiviral vector-based gene therapy is well tolerated and may improve motor function in patients with Parkinson’s disease, shows an open-label study published in The Lancet. [More]

Researcher finds possible way to unravel misfolded proteins by reprogramming yeast protein

At the heart of brain diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At present, there is no known way to reverse protein misfolding. [More]

Study links discrete area of brain to cognitive deficit in people at early stage of PD

Research by a team of investigators in Finland suggests that the free recall memory deficits common even in early stages Parkinson's disease (PD) are related to structural changes in the brain, specifically parietal cortical gray matter volume. [More]
Higher vitamin D levels linked with better cognition and less depression in PD patients

Higher vitamin D levels linked with better cognition and less depression in PD patients

A new study exploring vitamin D levels in patients with Parkinson's disease (PD) opens up the possibility of a new avenue of early intervention that may delay or prevent the onset of cognitive impairment and depression. The findings are published in the Journal of Parkinson's Disease. [More]

Study links a discrete area of the brain to cognitive deficit in people at early stage of PD

Research by a team of investigators in Finland suggests that the free recall memory deficits common even in early stages Parkinson's disease are related to structural changes in the brain, specifically parietal cortical gray matter volume. Their findings are published in the current issue of the Journal of Parkinson's Disease. [More]