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Fibrinogen could bypass intraoperative transfusion needs

Fibrinogen could bypass intraoperative transfusion needs

Giving fibrinogen as first-line treatment for intraoperative bleeding could reduce the need for blood transfusion, shows a small randomized controlled trial. [More]
Farmers face increased risk for multiple myeloma

Farmers face increased risk for multiple myeloma

People working as farmers and those with long-term exposure to pesticides have an increased risk for multiple myeloma, results of a large European study suggest. [More]
World Trade Center rescue workers may face increased cancer risk

World Trade Center rescue workers may face increased cancer risk

People who were involved in the rescue and recovery operation at the World Trade Center are at an increased risk for certain types of cancer, including prostate, thyroid, and myeloma, study findings suggest. [More]
Disparities in HIV care in Ontario

Disparities in HIV care in Ontario

Researchers have found significant disparities in hospital admission rates for certain groups of individuals living with HIV in Ontario, Canada. [More]
High-risk leukemia patients respond to novel drug

High-risk leukemia patients respond to novel drug

A third of adult leukemia patients given the novel drug quizartinib during a phase II study have achieved a composite response of either complete remission, or remission with incomplete platelet recovery or incomplete hematologic recovery, report US researchers. [More]
Complex process of bone disease evident in mastocytosis

Complex process of bone disease evident in mastocytosis

Patients with mastocytosis show elevated bone turnover that is associated with a higher mast cell load and advanced disease relative to individuals without the condition, suggest study findings. [More]
Ponatinib offers new hope in drug-resistant leukemia

Ponatinib offers new hope in drug-resistant leukemia

An investigational tyrosine kinase inhibitor, ponatinib, has shown high levels of activity in patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. [More]

‘Old’ erythrocytes little problem in noncardiac surgery

Erythrocytes that have been stored for several weeks before use may not cause problems in patients who receive transfusions during noncardiac surgery, a large retrospective analysis suggests. [More]
Hemorrhage risk ‘higher than reported’ for AF warfarin users

Hemorrhage risk ‘higher than reported’ for AF warfarin users

Real-world findings for atrial fibrillation patients using warfarin point to a significantly higher risk for hemorrhage than reported for clinical trials. [More]
Cryoprecipitate plus tranexamic acid boost war injury survival

Cryoprecipitate plus tranexamic acid boost war injury survival

Administration of cryoprecipitate and tranexamic acid significantly improves the likelihood of survival among seriously injured patients requiring packed red blood cells, suggest results from MATTERS II. [More]
No advantage of continuous over bolus doxorubicin in ALL children

No advantage of continuous over bolus doxorubicin in ALL children

Research suggests that there is no long-term advantage, in terms of cardioprotection or event-free survival, from giving continuous instead of bolus doxorubicin infusion in children with acute lymphoblastic leukemia. [More]
Adding bortezomib ‘boosts acute myeloid leukemia chemotherapy response’

Adding bortezomib ‘boosts acute myeloid leukemia chemotherapy response’

Older patients with untreated acute myeloid leukemia may benefit from having bortezomib added to daunorubicin and cytarabine during induction therapy and to consolidation intermediate-dose cytarabine, the results of a US study indicate. [More]
Thrombin sponge speeds cervical spine surgery discharge

Thrombin sponge speeds cervical spine surgery discharge

Application of a thrombin-soaked sponge after posterior cervical spine surgery allows patients to leave hospital earlier than normally expected, suggests research. [More]
Trauma transfusion ratios linked to survival

Trauma transfusion ratios linked to survival

Transfusion practices significantly predict early inhospital mortality among adult trauma patients, suggests a report published in the Archives of Surgery. [More]

Band counts in infection diagnosis

Even when patients have normal white blood cell counts, elevated band counts may diagnose infection and prompt earlier initiation of antibiotics, report researchers. [More]
Sapacitabine tolerated, efficacious in elderly leukemia patients

Sapacitabine tolerated, efficacious in elderly leukemia patients

The nucleoside analog sapacitabine appears to be “active and tolerable” in elderly patients with acute myeloid leukemia, say authors of a phase II study reported in the Lancet Oncology. [More]
Gene variant predicts lymphoma treatment response

Gene variant predicts lymphoma treatment response

German researchers have identified a gene variant that significantly influences the outcome of methotrexate therapy for primary central nervous system lymphoma. [More]
Intraoperative cardiac arrest most likely following heavy blood loss

Intraoperative cardiac arrest most likely following heavy blood loss

Study results show that although intraoperative cardiac arrest is rare during noncardiac surgery, patients who receive intraoperative blood transfusion are at increased risk for the event. [More]
Hemostatic testing may explain heavy menstrual bleeding

Hemostatic testing may explain heavy menstrual bleeding

Results of a US study show that hemostatic screening tests are important in the evaluation of young women with heavy menstrual bleeding. [More]
'Fresher' blood transfusion does not mean better outcomes

'Fresher' blood transfusion does not mean better outcomes

Blood that has been stored for 2 weeks or more before being used in transfusions for critically ill patients does not appear to cause adverse effects, report US researchers. [More]