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Positive bosutinib response for elderly blast phase CML patient

A case study suggests that the third-generation tyrosine kinase inhibitor bosutinib may be considered as induction therapy for blast phase chronic myeloid leukaemia in older patients.

22 Jan 2016

Cardiovascular considerations crucial for CML TKI patients

A review of BCR–ABL1 tyrosine kinase inhibitors highlights the need to consider cardiovascular adverse event risk profiles when prescribing for patients with chronic myeloid leukaemia.

22 Jan 2016

BCR–ABL transcript type linked to TKI response, outcomes

The type of BCR–ABL transcript could have an impact on tyrosine kinase inhibitor choice in patients with chronic myeloid leukaemia , according to research published in Blood.

22 Jan 2016

CML survey reveals patient TKI adherence, disease anxiety

Survey results suggest that chronic myeloid leukaemia patients using tyrosine kinase inhibitor therapy have good adherence to treatment but might benefit from counselling regarding their illness.

14 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

Adolescent and young adult patients with chronic myeloid leukaemia may have an unfavourable outcome on tyrosine kinase inhibitor therapy compared with their older counterparts, suggests a study of Japanese patients.

14 Aug 2015

Hedgehog blockade promising in myeloid malignancies

Phase I trial results published in The Lancet Haematology show that the hedgehog signalling pathway antagonist PF-04449913 is tolerable and has activity in patients with haematological cancers.

5 Aug 2015

New data driven approach to healthcare

Isansys Lifecare Ltd, the provider of complete real-time physiological patient data services and systems, is this week celebrating its fifth anniversary...

From Isansys Lifecare Ltd. 8 May 2015

IV iron dextran alternative to oral iron for anemia in nondialysis CKD

Treatment with intravenous low-molecular-weight iron dextran seems to be an effective alternative for patients with nondialysis chronic kidney disease who remain anemic despite receiving oral iron and erythropoiesis-stimulating agents.

8 Mar 2013

Zinc protoporphyrin a marker for iron deficiency in low-income children

Researchers say that zinc protoporphyrin could be a useful measure for screening infants from low-income families for iron deficiency, as well as for monitoring response to therapy, especially among children with anemia.

6 Mar 2013

Stem cell transplantation could be delayed in acute myeloid leukemia

Stem cell transplantation could be delayed until a relapse occurs, without affecting overall survival, in some patients with acute myeloid leukemia, UK researchers report.

5 Mar 2013

Anti-metabolic syndrome efforts needed for young ALL survivors

Children with acute lymphoblastic leukemia are at risk for developing the metabolic syndrome during maintenance therapy, suggest study findings.

5 Mar 2013

Protamine–heparin complex antibodies raise concerns

Almost a third of patients treated with protamine for heparin reversal during cardiopulmonary bypass develop antibodies to circulating protamine–heparin complexes, study findings suggest.

25 Feb 2013

Blood type, blood protein mutations influence thromboembolism risk

Findings from two Danish studies have shown that ABO blood type, both alone and in combination with the presence of factor V and prothrombin mutations, is associated with increases in risk for venous thromboembolism.

20 Feb 2013

Clonal evolution explains unpredictable leukemia disease course

Scientists have revealed the complicated clonal evolution of chronic lymphocytic leukemia, giving insight into the variation in disease course and its response to treatment.

19 Feb 2013

Xpert diagnosis of TB and its drug resistant strains

The use of a novel, diagnostic test called Xpert is both sensitive and specific in detecting tuberculosis and rifampicin resistance, report US researchers.

14 Feb 2013

Rivaroxaban ruled out for extended thromboprophylaxis

The benefits of extended prophylactic anticoagulation with rivaroxaban in acutely ill hospital patients are outweighed by an increased bleeding risk, shows a study in The New England Journal of Medicine.

14 Feb 2013

Burkitt lymphoma risk after transplantation highlighted

Solid organ transplant recipients have a significant risk for developing Burkitt lymphoma (BL), US researchers have found.

12 Feb 2013

Detection of B cells may predict graft-versus-host disease

The ability to detect B cells specific to the DEAD box protein may help predict the development of chronic graft-versus-host disease in male recipients of female hematopoietic cells, according to recent findings.

5 Feb 2013