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CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

Immune dysregulation in long COVID patients uncovered in new study

Sstudy reveals significant immune changes in long COVID patients, including altered T cell responses and systemic inflammation, using advanced 'omics' and serological assays.

14 Jan 2024

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Researchers immunophenotyped T lymphocyte responses among unvaccinated individuals, representative of the entire spectrum of the clinical presentation of COVID-19.

28 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Mechanical forces generated by T cells influence the destruction of cancer cells

As a part of our immune defenses, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.

15 Sep 2022

Mechanism of action of different COVID-19 vaccines

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Tuebingen and Imperial College London assessed humoral and cellular immune responses elicited by the recombinant adenoviral vector (rAdVV)- and messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccines.

14 Sep 2022

Scientists explore associations between SARS-CoV-2 neutralizing antibodies and receptor-binding domain-selective proliferative memory CD4 T cells

Researchers depicted the correlations between receptor-binding domain (RBD)-selective proliferative memory CD4 T cells and neutralizing antibodies in COVID-19 vaccinees and convalescent patients.

27 Jul 2022

What is the association between natural killer cell dysfunction and COVID-19 disease severity?

Researchers assessed the association between natural killer cell dysfunction and COVID-19 disease severity.

20 Jul 2022

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in COVID-19 patients.

9 May 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

In a new study, researchers evaluated antibody responses in mild cases of coronavirus disease 2019.

26 Apr 2022

mRNA vaccines induce CD8+ T cells that may reduce COVID-19 severity

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-specific cluster of differentiation 8 (CD8+) T cell responses.

12 Apr 2022

Perforin News and Research

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Immune dysregulation in long COVID patients uncovered in new study

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

A microbiota-driven mechanism underlies severity of leishmaniasis infection

Mechanical forces generated by T cells influence the destruction of cancer cells

Mechanism of action of different COVID-19 vaccines

Scientists explore associations between SARS-CoV-2 neutralizing antibodies and receptor-binding domain-selective proliferative memory CD4 T cells

What is the association between natural killer cell dysfunction and COVID-19 disease severity?

Study investigates the cause of lymphopenia as seen in COVID-19 patients

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

mRNA vaccines induce CD8+ T cells that may reduce COVID-19 severity

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

CD4 T-cell immunity active six months into COVID-19 convalescence

Investigating the immunology of COVID-19 infected children

Immunological factors associated with impaired BNT162b2 mRNA vaccine response in older adults

The role of T follicular helper cells in the humoral immune response to SARS-CoV-2

Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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