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Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

More than 100 types of peripheral neuropathy have been identified, each with its own characteristic set of symptoms, pattern of development, and prognosis. Impaired function and symptoms depend on the type of nerves -- motor, sensory, or autonomic -- that are damaged. Some people may experience temporary numbness, tingling, and pricking sensations, sensitivity to touch, or muscle weakness. Others may suffer more extreme symptoms, including burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction. Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, and vascular and metabolic disorders. Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders affecting nerve tissue. Inherited forms of peripheral neuropathy are caused by inborn mistakes in the genetic code or by new genetic mutations.
Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV. [More]
Research reveals causes of motor abnormalities in low birth weight babies

Research reveals causes of motor abnormalities in low birth weight babies

In the February issue of the American Journal of Pathology, new research from the University of Chicago shows motor abnormalities frequently associated with low birth weight babies could originate due to peripheral nerve defects. [More]
Hospitals eliminate bedsore occurrence using early detection technology

Hospitals eliminate bedsore occurrence using early detection technology

Using technology adapted from NASA's Mars lander as part of a large-scale bedsore reduction program, over half of the 13 participating hospitals were able to eliminate the occurrence of new bedsores completely; an additional 3 hospitals achieved reductions ranging from 11% to 90%. [More]
Person's ‘brain speed’ may matter more than other risk factors for geriatric falls

Person's ‘brain speed’ may matter more than other risk factors for geriatric falls

"Why does a 30-year-old hit their foot against the curb in the parking lot and take a half step and recover, whereas a 71-year-old falls and an 82-year-old falls awkwardly and fractures their hip?" asks James Richardson, M.D., professor of physical medicine and rehabilitation at the University of Michigan Comprehensive Musculoskeletal Center. [More]
Melanoma drug offers considerable added benefit for patients with advanced NSCLC

Melanoma drug offers considerable added benefit for patients with advanced NSCLC

Pembrolizumab was initially introduced for the treatment of melanoma. Since July 2016, the monoclonal antibody has also been available for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in adults whose tumours express the T-cell receptor ligand PD-L1 and who have received a prior chemotherapy regimen. [More]
High folate intake may increase risk of peripheral neuropathy in older adults with common gene variant

High folate intake may increase risk of peripheral neuropathy in older adults with common gene variant

Consuming too much folate (vitamin B9) is associated with increased risk for a nerve-damage disorder in older adults who have a common genetic variant. [More]
Scientists report new neurological complication from Zika virus infection

Scientists report new neurological complication from Zika virus infection

Dr. John England, Professor and Chair of Neurology at LSU Health New Orleans School of Medicine, and colleagues in Honduras and Venezuela have reported a new neurological complication of infection with the Zika virus. [More]
MDI Biological Laboratory receives NIH grant for research on peripheral neuropathy

MDI Biological Laboratory receives NIH grant for research on peripheral neuropathy

The MDI Biological Laboratory has announced that it has received a grant of $456,500 over two years from the National Institutes of Health for the study of peripheral neuropathy. [More]
Scientists unravel effect of prion proteins on the nerves

Scientists unravel effect of prion proteins on the nerves

Ever since the prion gene was discovered in 1985, its role and biological impact on the neurons has remained a mystery. [More]
FDA approves safety labeling changes for fluoroquinolone antibiotics

FDA approves safety labeling changes for fluoroquinolone antibiotics

The U.S. Food and Drug Administration today approved safety labeling changes for a class of antibiotics, called fluoroquinolones, to enhance warnings about their association with disabling and potentially permanent side effects and to limit their use in patients with less serious bacterial infections. [More]
Study reports BV therapy may be curative in some Hodgkin lymphoma patients

Study reports BV therapy may be curative in some Hodgkin lymphoma patients

Five-year survival data published online today in Blood, the Journal of the American Society of Hematology, suggest that the targeted therapy brentuximab vedotin may have cured some Hodgkin lymphoma patients whose disease has persisted despite receiving previous therapies. [More]
Argentine Tango dance holds potential to reduce fall risk among cancer survivors with neuropathy

Argentine Tango dance holds potential to reduce fall risk among cancer survivors with neuropathy

Dance as a form of therapy - specifically Argentine Tango -- has the potential to significantly improve balance and reduce falls risk among cancer patients experiencing peripheral neuropathy, according to new research conducted by a multidisciplinary research team at The Ohio State University. [More]
Oncologists to present latest research findings at ASCO annual meeting

Oncologists to present latest research findings at ASCO annual meeting

Oncologists from NewYork-Presbyterian, Columbia University Medical Center and Weill Cornell Medicine will discuss their latest research findings at the American Society for Clinical Oncology annual meeting, June 3-7 in Chicago. [More]
NR supplements can reduce diabetes-related complications in mice

NR supplements can reduce diabetes-related complications in mice

A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System. [More]
Microvascular disease burden tied to CVD outcomes in diabetic patients

Microvascular disease burden tied to CVD outcomes in diabetic patients

The risk of cardiovascular disease events in patients with Type 2 diabetes rises in line with their cumulative burden of microvascular disease, research shows. [More]
Multivitamin use prior to diagnosis may reduce effects of CIPN in breast cancer survivors

Multivitamin use prior to diagnosis may reduce effects of CIPN in breast cancer survivors

Researchers at Roswell Park Cancer Institute, in collaboration with investigators from the cooperative group SWOG, have found that use of multivitamins prior to diagnosis may reduce the risk of neuropathy in breast cancer patients treated with the class of drugs known as taxanes. The team will present their findings at the American Association for Cancer Research Annual Meeting 2016, to be held April 16-20 in New Orleans. [More]
Small fibre neuropathy defies 'dying-back' nerve process

Small fibre neuropathy defies 'dying-back' nerve process

Neuronal degradation in patients with small fibre neuropathy is not dependent on nerve fibre length, study findings suggest. [More]
Scientists discover underlying mechanisms of nerve damage

Scientists discover underlying mechanisms of nerve damage

Recent research by Sandra Rieger, Ph.D., of the MDI Biological Laboratory identifying the underlying mechanisms of peripheral neuropathy, or nerve damage, has raised the prospect that drug therapies can be developed for the treatment of this condition, which causes pain, numbness and/or tingling in the hands and feet. The research was published March 28 in the Proceedings of the National Academy of Sciences. [More]
Neurofeedback decreases pain, increases quality of life in patients with neuropathic pain

Neurofeedback decreases pain, increases quality of life in patients with neuropathic pain

A new study from The University of Texas MD Anderson Cancer Center evaluating the use of neurofeedback found a decrease in the experience of chronic pain and increase quality of life in patients with neuropathic pain. [More]
MDI Biological Laboratory scientist identifies potential drug therapy to reverse peripheral nerve damage

MDI Biological Laboratory scientist identifies potential drug therapy to reverse peripheral nerve damage

The Mount Desert Island Biological Laboratory has announced that assistant professor Sandra Rieger, Ph.D., has identified two drugs that could potentially be used to reverse peripheral nerve damage, or peripheral neuropathy, resulting from chemotherapy treatment for ovarian, breast, lung, pancreas and other cancers. The drugs also have potential applications for the treatment of peripheral nerve damage caused by diabetes, traumatic injuries and other conditions. [More]
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