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KAIST scientists predict how biological circuits sustain rhythms

KAIST scientists predict how biological circuits sustain rhythms

Our bodies have a variety of biological clocks that follow rhythms or oscillations with periods ranging from seconds to days. For example, our hearts beat every second, and cells divide periodically. The circadian clock located in the hypothalamus generates twenty-four hour rhythms, timing our sleep and hormone release. [More]
Adaptive immune system plays active role in guiding development of mammary glands

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty. [More]
Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system. [More]
Mylan releases generic version of Zosyn Injection in the U.S.

Mylan releases generic version of Zosyn Injection in the U.S.

Mylan N.V. today announced the U.S. launch of Piperacillin and Tazobactam for Injection USP, 3.375g Single-dose Vials, which is the generic version of Pfizer's Zosyn Injection. [More]
New study offers first clinical recommendations for headache diagnosis in pregnant women

New study offers first clinical recommendations for headache diagnosis in pregnant women

If a pregnant woman with high blood pressure and no history of headache suddenly develops a headache that quickly gets worse, she could be at risk for pregnancy complications, including preeclampsia, which put both the mother and fetus at risk. [More]
Rhythm Metabolic completes $40 million Series A financing

Rhythm Metabolic completes $40 million Series A financing

Rhythm announced today the completion of a $40 million Series A financing for its subsidiary, Rhythm Metabolic, Inc., which is developing setmelanotide (RM-493), a novel peptide MC4 agonist for the treatment of obesity caused by genetic deficiencies in the MC4 pathway. [More]
New combination vaccine may reduce number of injections for young children

New combination vaccine may reduce number of injections for young children

A new combination vaccine may reduce the number of injections required to keep infants and toddlers up to date with the United States infant immunization schedule recommended by the Centers for Disease Control and Prevention. In a phase III trial reported in the August 2015 issue of Pediatrics, the vaccine was determined to be effective, safe and well-tolerated. Gary S. Marshall, M.D., professor of pediatrics at the University of Louisville, was the principal investigator of the multi-center trial and first author of the report. [More]
Common marker can help identify patients at high risk for deadly cardiac events

Common marker can help identify patients at high risk for deadly cardiac events

A marker commonly used to determine if a patient is having a heart attack can also be used to identify stable patients at high risk for deadly cardiac events, according to a new study led by investigators at Brigham and Women's Hospital. [More]
Postmenopausal women more likely to use vaginal estrogen to achieve significantly higher sexual quality of life

Postmenopausal women more likely to use vaginal estrogen to achieve significantly higher sexual quality of life

Local vaginal estrogen (VE) appears to have escaped the shroud of doubt cast upon hormone therapy as a result of the Women's Health Initiative Study by providing numerous medical benefits without systemic effects. That's according to a new study reported online today in Menopause, the journal of The North American Menopause Society. [More]
Johns Hopkins and Mayo Clinic cardiologists suggest upgrades to controversial heart disease prevention guidelines

Johns Hopkins and Mayo Clinic cardiologists suggest upgrades to controversial heart disease prevention guidelines

Acknowledging key strengths and "lessons learned," preventive cardiologists from Johns Hopkins and Mayo Clinic have developed a short list of suggested upgrades to the controversial heart disease prevention guidelines issued jointly in 2013 by the American Heart Association and the American College of Cardiology. [More]

Global Pharmaceutical Contract Manufacturing market estimated to reach $84 billion in 2020

Mordor Intelligence releases their report on the Global Pharmaceutical Contract Manufacturing market is segmented by Dose Formulation type (Solid Dose Formulation, Liquid Dose Formulation, Injectable Dose Formulation - By Geographical Region (North America, Europe, Latin America, APAC, Middle East & Africa) - Drivers, Restraints, Vendor Profiles, Global Market Size, Forecasts & Analysis (2015-2020). [More]
New article proposes creation of $2 billion global vaccine-development fund to prevent infectious diseases

New article proposes creation of $2 billion global vaccine-development fund to prevent infectious diseases

Ebola is a preventable disease, and yet a safe and effective vaccine has not been deployed. As with many vaccines, financial barriers persist: pharmaceutical companies see high costs with limited market potential, and government support is lacking. But there may be a solution to this vaccine crisis with the ability to save at-risk populations, according to a perspective piece written by physicians based at Princeton University, University of Pennsylvania and the Wellcome Trust. [More]
Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai Inc. announced today that its parent company Eisai Co., Ltd. (Headquarters: Tokyo, President and CEO: Haruo Naito) and Halozyme Therapeutics, Inc. (Headquarters: San Diego, California, President and CEO: Dr. Helen Torley) have signed a clinical collaboration agreement to evaluate Eisai's agent eribulin mesylate (brand name: Halaven, "eribulin") in combination with Halozyme's investigational drug PEGPH20 (PEGylated recombinant human hyaluronidase) in first line HER2-negative metastatic breast cancer. [More]
Researchers establish safety, dosing of new drug for treating blood cancers

Researchers establish safety, dosing of new drug for treating blood cancers

Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers. The findings are published online July 27 in The Lancet Haematology. [More]
Trends, R&D progress, and predicted revenues in RNAi therapies

Trends, R&D progress, and predicted revenues in RNAi therapies

When will RNAi therapies reach the market? Visiongain's brand new report shows you potential revenues to 2025, assessing data, trends, opportunities and prospects there. [More]
Smokers who switch to low-nicotine cigarettes find difficult to curb smoking habits in the long term

Smokers who switch to low-nicotine cigarettes find difficult to curb smoking habits in the long term

Smokers who successfully lowered their nicotine intake when they were switched to low-nicotine cigarettes were unable to curb their smoking habits in the long term, according to a study by researchers at UCSF and San Francisco General Hospital and Trauma Center. [More]
More people turn to popular new blood thinners for atrial fibrillation treatment

More people turn to popular new blood thinners for atrial fibrillation treatment

More adults than ever are visiting their doctors' offices for a prescription to treat atrial fibrillation, according to a study led by the University of Michigan Frankel Cardiovascular Center. [More]
GUMC physician leads new national clinical trial for melanoma treatment

GUMC physician leads new national clinical trial for melanoma treatment

A Georgetown University Medical Center physician renowned for his research in melanoma will lead a new national clinical trial involving novel treatments for the disease. The study compares the sequencing of two groups of drugs -- both effective in treating melanoma. [More]
Tobacco cessation service provides survival benefit for lung cancer patients who quit smoking

Tobacco cessation service provides survival benefit for lung cancer patients who quit smoking

Tobacco cessation provided significant survival benefit for lung cancer patients who quit smoking shortly before or after diagnosis, despite the severity of the disease. Results of the Roswell Park Cancer Institute study were published in the Journal of Thoracic Oncology. [More]
SUNY Downstate Medical Center researchers identify ALPIM syndrome as new spectrum disorder

SUNY Downstate Medical Center researchers identify ALPIM syndrome as new spectrum disorder

The relationship between mental and physical health is well established. But when mental and physical illnesses co-occur, patients' accounts of physical illness are sometimes arbitrarily discredited or dismissed by physicians. [More]
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