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Pneumonia is a leading cause of death and hospitalization, costing health care systems billions of dollars and an estimated 600,000 adult deaths worldwide each year. Pneumococcal disease is caused by the bacterium Streptococcus pneumoniae and the term describes a group of illnesses, including invasive infections, such as bacteremia/sepsis and meningitis, as well as pneumonia and upper respiratory tract infections. Although all age groups may be affected, the highest rate of pneumococcal disease occurs in young children and older adults. In addition, persons suffering from a wide range of chronic conditions (eg, diabetes, cardiovascular disease) and immune deficiencies are at increased risk.
Study explains long-term pulmonary outcomes among childhood cancer survivors

Study explains long-term pulmonary outcomes among childhood cancer survivors

A team of researchers from nine leading academic hospitals and research centers have published a paper in the early online edition of the journal Cancer that describes pulmonary outcomes among childhood cancer survivors. [More]
Researchers explain why secondary infection with MRSA kills influenza patients

Researchers explain why secondary infection with MRSA kills influenza patients

Researchers have discovered that secondary infection with the Methicillin-resistant Staphylococcus aureus (MRSA) bacterium (or "superbug") often kills influenza patients because the flu virus alters the antibacterial response of white blood cells, causing them to damage the patients' lungs instead of destroying the bacterium. [More]
St. Jude scientists identify key innate immune sensor that attacks influenza virus

St. Jude scientists identify key innate immune sensor that attacks influenza virus

St. Jude Children's Research Hospital immunologists have identified the protein trigger in the body's quick-reaction innate immune system that specifically recognizes the influenza virus in infected cells and triggers their death. [More]
Study shows hospitals that send more number of heart patients to ICU perform worse in quality of care

Study shows hospitals that send more number of heart patients to ICU perform worse in quality of care

Patients who suffer heart attacks, or flare-ups of congestive heart failure, can be cared for in a variety of hospital locations. But a new study suggests that they'll fare worse in hospitals that rely heavily on their intensive care units to care for patients like them. [More]
Oxford researchers developing new automated system for easier, cheaper diagnosis of pneumonia

Oxford researchers developing new automated system for easier, cheaper diagnosis of pneumonia

Oxford researchers are developing a tool to make it much easier and cheaper to diagnose pneumonia -- the number one killer of children under 5. Their latest research is published in Journal of the Royal Society Interface. [More]
Research findings may offer new way to strengthen body’s natural defenses to battle pneumonia

Research findings may offer new way to strengthen body’s natural defenses to battle pneumonia

A molecule being targeted in cancer is also critical for the immune system's ability to battle pneumonia, researchers at the University of Virginia School of Medicine have determined. [More]
Valley fever diagnosis often overlooked by primary care physicians

Valley fever diagnosis often overlooked by primary care physicians

For patients with pneumonia or ongoing influenza-like symptoms who live in or have visited the west or southwest United States, especially Arizona and central California, infectious diseases experts recommend physicians suspect valley fever, an often-overlooked fungal infection. [More]
FDA approves safety labeling changes for fluoroquinolone antibiotics

FDA approves safety labeling changes for fluoroquinolone antibiotics

The U.S. Food and Drug Administration today approved safety labeling changes for a class of antibiotics, called fluoroquinolones, to enhance warnings about their association with disabling and potentially permanent side effects and to limit their use in patients with less serious bacterial infections. [More]
New analysis reveals ways to reduce patient's risk of postoperative pneumonia after cardiac surgery

New analysis reveals ways to reduce patient's risk of postoperative pneumonia after cardiac surgery

Pneumonia is the most prevalent infection after open heart surgery, leading to longer hospital stays and lower odds of survival. [More]
Scientists develop prediction score to identify older adults at risk of developing pneumonia

Scientists develop prediction score to identify older adults at risk of developing pneumonia

In a study published in the Journal of American Geriatrics Society, researchers developed a "prediction score" to help healthcare professionals determine which older adults might be most at risk for developing pneumonia. [More]
Exposure to atmospheric dust, high temperatures can increase risk of bacterial meningitis

Exposure to atmospheric dust, high temperatures can increase risk of bacterial meningitis

Exposure to airborne dust and high temperatures are significant risk factors for bacterial meningitis, a new study by the University of Liverpool's Institute of Infection and Global Health has found. [More]
New study identifies alternative route for tuberculosis infection

New study identifies alternative route for tuberculosis infection

Researchers from UT Southwestern Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore. [More]
Study develops new methodology to analyse genetic bases of pathogenic bacteria

Study develops new methodology to analyse genetic bases of pathogenic bacteria

The study has developed a pioneering methodology to analyse the genetic bases of pathogenic bacteria and can be used to identify therapeutic targets in order to develop new antimicrobial agents. [More]
ART could help reduce opportunistic infections and save lives of HIV-infected children

ART could help reduce opportunistic infections and save lives of HIV-infected children

According to the World Health Organization (WHO), 150,000 children with HIV under 15 years of age died of opportunistic infections in low-to-middle income countries in 2014 alone. [More]
First clinical study for Zika vaccine to begin in Canada

First clinical study for Zika vaccine to begin in Canada

Université Laval's Infectious Disease Research Centre and Centre de recherche du CHU de Québec-Université Laval are proud to announce that the first clinical study for a Zika vaccine in Canada is set to begin in Quebec City. [More]
IDSA/ATS recommends shorter courses of antibiotics for patients with hospital-acquired, ventilator-associated pneumonia

IDSA/ATS recommends shorter courses of antibiotics for patients with hospital-acquired, ventilator-associated pneumonia

Hospital-acquired pneumonia and ventilator-associated pneumonia– which account for 20 to 25 percent of hospital-acquired infections – should be treated with shorter courses of antibiotics than they typically are, according to new guidelines released by the Infectious Diseases Society of America and American Thoracic Society and published in the journal Clinical Infectious Diseases. [More]
Researchers discover strong genetic risk factor for IgA nephropathy

Researchers discover strong genetic risk factor for IgA nephropathy

An international research collaboration has discovered a strong genetic risk factor for IgA nephropathy (IgAN) - the most common inflammatory kidney disease worldwide - and related renal dysfunction. [More]
AHSN already working to tackle sepsis across North East and North Cumbria

AHSN already working to tackle sepsis across North East and North Cumbria

Doctors and nurses in the region have been working collaboratively for over a year to ensure the effective recognition and response to sepsis. [More]
Scientists discover new biological defense system against pathogenic microorganisms

Scientists discover new biological defense system against pathogenic microorganisms

For the first time in the world, a group of researchers discovered a human immune receptor, which detects the invasion of pathogenic microorganisms. [More]
Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies. [More]
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