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Pneumonia is a leading cause of death and hospitalization, costing health care systems billions of dollars and an estimated 600,000 adult deaths worldwide each year. Pneumococcal disease is caused by the bacterium Streptococcus pneumoniae and the term describes a group of illnesses, including invasive infections, such as bacteremia/sepsis and meningitis, as well as pneumonia and upper respiratory tract infections. Although all age groups may be affected, the highest rate of pneumococcal disease occurs in young children and older adults. In addition, persons suffering from a wide range of chronic conditions (eg, diabetes, cardiovascular disease) and immune deficiencies are at increased risk.

UNICEF report highlights gains in child health, while 1b still lack essential services

20. November 2009 23:47
A special edition of UNICEF's annual State of the World's Children report, released 20 years after the U.N. Convention on the Rights of the Child, shows that "fewer youngsters are dying and more are going to school - but an estimated 1 billion still lack services essential to their survival and development," the Associated Press reports. [More]

Posted in: Child Health News | Disease/Infection News

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FDA approves sNDA for pediatric autism drug ABILIFY

20. November 2009 23:40
Bristol-Myers Squibb Company and Otsuka Pharmaceutical Co., Ltd. announced today that the U.S. Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for ABILIFY® (aripiprazole) for the treatment of irritability associated with autistic disorder in pediatric patients ages 6 to 17 years, including symptoms of aggression towards others, deliberate self-injuriousness, temper tantrums, and quickly changing moods. [More]

Study recommends chest ultrasound for evaluating pediatric patients with complicated pneumonia

20. November 2009 23:15
Chest ultrasound can serve as a viable alternative to chest CT in the evaluation of pediatric patients with complicated pneumonia and parapneumonic effusion (a build-up of fluid between the lung and chest wall), according to a study published in the December issue of the American Journal of Roentgenology. [More]

Posted in: Child Health News | Device / Technology News | Disease/Infection News

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Leading driver of antibiotic selection in nosocomial pneumonia in Europe found

20. November 2009 01:19
Arlington Medical Resources (AMR) and Decision Resources find that the leading driver of antibiotic selection in nosocomial pneumonia in Europe is broad-spectrum activity against gram-positive and gram-negative pathogens. [More]

Posted in: Disease/Infection News

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FDA Advisory Committee votes in support of Pfizer's Prevnar 13

19. November 2009 03:42
Pfizer Inc announced today that the U.S. Food and Drug Administration’s (FDA) Vaccines and Related Biological Products Advisory Committee voted 10 to 1 that the data presented support the safety and effectiveness of its 13-valent pneumococcal conjugate candidate vaccine, Prevnar 13™ (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), for the prevention of invasive pneumococcal disease in infants and young children. [More]

Millennium commences Phase I clinical trial for its second-generation proteasome inhibitor

18. November 2009 10:31
Millennium: The Takeda Oncology Company today announced it has further expanded its protein homeostasis program with the initiation of a Phase I clinical trial for an oral formulation of MLN9708, the Company’s second-generation proteasome inhibitor. An intravenous formulation of MLN9708 entered clinical trials in March. [More]

Pentavalent price drops: the GAVI effect

18. November 2009 06:02
Following the increasing impact of the GAVI Alliance on the vaccine market, the price of one of the major combination vaccines, the pentavalent, is falling considerably, enabling GAVI’s partners to vaccinate millions of more children in the developing world. [More]

Posted in: Child Health News | Pharmaceutical News

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Regulatory agencies offer marketing approval for new products to treat neglected diseases

18. November 2009 04:41
New products to treat neglected diseases have received marketing approval from regulatory agencies at a steadily increasing rate in recent years as R&D funding for those diseases has increased, according to a recently completed study by the Tufts Center for the Study of Drug Development. [More]

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Report calls for refocusing health spending in developing countries to save children's lives

17. November 2009 23:57
"More than 24,000 infants die daily from preventable diseases in developing countries," and child deaths have fallen in countries where governments "have shown a high level of political leadership on child health," World Vision International said in a new report (.pdf) released on Monday as part of a five-year campaign to reduce child deaths worldwide, the Associated Press/San Francisco Chronicle reports. [More]

Posted in: Child Health News | Healthcare News

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Hospitals should expand quality control guidelines to improve surgical complications in older patients

17. November 2009 02:00
The elderly are more vulnerable to problems after a major surgical procedure than younger patients, but a team of investigators using data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) suggest that one way to improve surgical results in this age group is to have hospitals expand their quality control guidelines to include more types of surgery-related complications. [More]

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Opinions: Health system funding; malnutrition assistance; social dimension of HIV

16. November 2009 23:22
"For too long, global health funding has gone to diseases like AIDS with the most vocal lobby groups and not to the diseases with the greatest need," Philip Stevens, a senior fellow at International Policy Network, writes in a Business Daily opinion piece. [More]

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Alkermes' phase 3 trial of naltrexone XR-NTX meets primary endpoint

16. November 2009 08:49
Alkermes, Inc. today announced positive preliminary results from a phase 3 clinical trial of naltrexone for extended-release injectable suspension (XR-NTX) for the treatment of opioid dependence. The six-month phase 3 study met its primary efficacy endpoint and data showed that patients treated once-monthly with XR-NTX demonstrated statistically significant higher rates of clean (opioid-free) urine screens, compared to patients treated with placebo, as measured by the cumulative distribution of clean urine screens (p<0.0002). [More]

Low-cost, simple interventions could save 2.5 million child lives a year: World Vision

16. November 2009 05:12
Almost a third of the children under age five who die each year could be saved if governments rebalance health spending to ensure low-cost, simple interventions such as safe water and hygiene, bed nets and basic maternal and newborn care, leading aid agency World Vision said today. Currently, 8.8 million children a year die before age five, most of preventable causes. [More]

Posted in: Child Health News

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UT physicians treat Iraqi girl with myasthenia gravis

16. November 2009 05:05
Plagued by a growing weakness that left her unable to walk, talk and even take a normal breath, 11-year-old Iraqi Aram Ali was a shell of the bright little girl she used to be. [More]

WHO revises clinical H1N1 guidelines, sends antivirals to some hard-hit nations

16. November 2009 03:26
On Thursday, the WHO issued revised guidance for the clinical management of H1N1 (swine) flu, the Associated Press reports. According to the AP, the WHO "says doctors shouldn't wait for lab confirmation before giving anti-viral drugs to pregnant women and other at-risk groups with suspected swine flu" (11/12). [More]

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