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New technology to study interactions between metal elements, molecules in living organisms

New technology to study interactions between metal elements, molecules in living organisms

Metal elements and molecules interact in the body but visualizing them together has always been a challenge. Researchers from the RIKEN Center for Life Science Technologies in Japan have developed a new molecular imaging technology that enables them to visualize bio-metals and bio-molecules simultaneously in a live mouse. [More]
Study shows taste of alcoholic drink can elicit dopamine activity in brain's reward centers

Study shows taste of alcoholic drink can elicit dopamine activity in brain's reward centers

The taste of beer, without any effect from alcohol itself, can trigger dopamine release in the brain, which is associated with drinking and other drugs of abuse, according to Indiana University School of Medicine researchers. [More]
Researchers use brain-imaging tool and stroke risk assessment to detect signs of cognitive decline

Researchers use brain-imaging tool and stroke risk assessment to detect signs of cognitive decline

UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia. [More]
Navidea commences enrollment in NAV4694 Phase 2b study to detect erebral β-amyloid plaque

Navidea commences enrollment in NAV4694 Phase 2b study to detect erebral β-amyloid plaque

Navidea Biopharmaceuticals, Inc., a biopharmaceutical company focused on precision diagnostic radiopharmaceuticals, today announced that enrollment has commenced in its Phase 2b, open-label, safety and efficacy positron emission tomography imaging study of [18F]NAV4694 for detection of cerebral β-amyloid plaque in subjects diagnosed with Mild Cognitive Impairment. [More]
Study provides understanding of root causes of clinical variability in anxiety disorders

Study provides understanding of root causes of clinical variability in anxiety disorders

New findings from nonhuman primates suggest that an overactive core circuit in the brain, and its interaction with other specialized circuits, accounts for the variability in symptoms shown by patients with severe anxiety. [More]
Luminex collaborates with Merck to design companion diagnostic device for Alzheimer’s disease

Luminex collaborates with Merck to design companion diagnostic device for Alzheimer’s disease

WHITEHOUSE STATION known as MSD outside the United States and Canada, and Luminex Corporation have signed a collaboration and license agreement to develop a companion diagnostic device that will be evaluated to help screen patients for recruitment into Merck's clinical development program for MK-8931, a novel oral beta amyloid precursor protein site cleaving enzyme (BACE) inhibitor and Merck's lead investigational candidate for Alzheimer's disease (AD). [More]

Possible alternative to biopsy discovered for renal cancer diagnosis

Combining positron emission tomography scanning with iodine-124 (124I)–girentuximab may offer an effective noninvasive method of diagnosing clear cell renal cell carcinoma in patients who present with a renal mass, US study results suggest. [More]
MILabs VECTor/CT installed by Molecular Imaging Center Antwerp (MICA) in Belgium

MILabs VECTor/CT installed by Molecular Imaging Center Antwerp (MICA) in Belgium

MILabs B.V. is pleased to announce that the Molecular Imaging Center Antwerp (MICA) in Belgium has installed a MILabs VECTor/CT to enhance their portfolio of pre-clinical nuclear oncology and neurology imaging and research capabilities. [More]
Stress and mental illness: an interview with Professor Akira Sawa

Stress and mental illness: an interview with Professor Akira Sawa

As a psychiatrist I am interested in how stress may play a role in the pathology of adult mental disorders. You may know that most of the major mental illnesses, such as schizophrenia, mood-disorder, substance abuse or even anxiety disorder, become prominent in early adulthood. [More]
Familial psychosis risk linked to prefrontal dopamine dysfunction

Familial psychosis risk linked to prefrontal dopamine dysfunction

People at familial risk for psychosis have attenuated dopamine stress modulation in the ventromedial prefrontal cortex, according to a recent in vivo imaging study. [More]
PET with 11C-PIB can positively visualize amyloid deposits in the heart

PET with 11C-PIB can positively visualize amyloid deposits in the heart

While amyloid imaging may now be most associated with detecting plaques in the brain, it has the potential to change the way cardiac amyloidosis is diagnosed. According to first-of-its-kind research published in the February issue of The Journal of Nuclear Medicine, positron emission tomography (PET) with 11C-PIB can positively visualize amyloid deposits in the heart. [More]
Alzheimer's Association, SNMMI publish appropriate use criteria for brain amyloid imaging with PET

Alzheimer's Association, SNMMI publish appropriate use criteria for brain amyloid imaging with PET

Only recently has it become possible to create high-quality images of the brain plaques characteristic of Alzheimer's disease in living people through positron emission tomography (PET). Even so, questions remain about what can be learned from these PET images and which people should have this test. [More]
UCLA researchers identify abnormal tau proteins associated with sports-related concussions

UCLA researchers identify abnormal tau proteins associated with sports-related concussions

Sports-related concussions and mild traumatic brain injuries have grabbed headlines in recent months, as the long-term damage they can cause becomes increasingly evident among both current and former athletes. The Centers for Disease Control and Prevention estimates that millions of these injuries occur each year. [More]
Aggressive surveillance questionable for eye melanoma recurrence

Aggressive surveillance questionable for eye melanoma recurrence

Patients treated for primary choroidal or ciliary body melanoma may not always benefit from an aggressive surveillance strategy for the detection of metastatic disease, caution US researchers. [More]
18F-FDG PET/CT may become important distant staging modality in patients with breast cancer

18F-FDG PET/CT may become important distant staging modality in patients with breast cancer

New research published in the January issue of The Journal of Nuclear Medicine shows that 18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging offers significant prognostic stratification information at initial staging for patients with locally advanced breast cancer. When compared to conventional imaging, 18F-FDG PET/CT more accurately showed lesions in the chest, abdomen and bones in a single session, changing management for more than 50 percent of the patients in the study. [More]
New cost-effective, less invasive MRI method for diagnosis of dementia

New cost-effective, less invasive MRI method for diagnosis of dementia

A new way to use MRI scans may help determine whether dementia is Alzheimer's disease or another type of dementia, according to new research published in the December 26, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology. [More]

Bipolar subtypes show neurobiologic differences

Results from a Taiwanese study show that there are significant neurobiologic differences between patients with bipolar I and II disorder. [More]
FAC PET identifies liposarcoma tumors that are sensitive to chemotherapy

FAC PET identifies liposarcoma tumors that are sensitive to chemotherapy

Liposarcoma, the most common type of sarcoma, is an often lethal form of cancer that develops in fat cells. It is particularly deadly, in part, because the tumors are not consistently visible with positron emission tomography (PET) scans that use a common probe called FDG and because they frequently do not respond to chemotherapy. [More]

Combination of diagnostic tests can predict conversion from MCI to Alzheimer's

A combination of diagnostic tests, including imaging and cerebrospinal fluid biomarkers can improve prediction of conversion from mild cognitive impairment (MCI) to Alzheimer's disease, according to a new study published online in the journal Radiology. [More]

Studies explore F-18-FLT PET utility in providing prognostic information for patients with gliomas

In the management of gliomas-or tumors that originate in the brain-precise assessment of tumor grade and the proliferative activity of cells plays a major role in determining the most appropriate treatment and predicting overall survival. [More]