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Study shows the benefits of locally administered intranasal live-attenuated SARS-CoV-2 vaccine

Rocketvax AG, together with the German Research Foundation (DFG), has financially supported a study carried out as part of a joint project of the Swiss National Science Foundation (SNSF, National Research Program "Covid-19," NRP 78) and the German Research Foundation (DFG) "Recoding the SARS-CoV-2 Genome - A Multidisciplinary Approach to Generate Live-Attenuated Coronavirus Vaccines."

27 Feb 2024

Optibrium launches a metabolism prediction software platform tailored to DMPK scientists

Semeta™ offers high sensitivity and superior precision for the prediction of Phase I and II metabolic routes, sites, products and liabilities in early drug discove.ry

From Optibrium Ltd. 27 Feb 2024

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

University of Maryland School of Medicine Dean Mark T. Gladwin, MD, announced today that UMSOM faculty scientists have been selected as key contractors by the Biomedical Advanced Research and Development Authority (BARDA), for the federal agency's Radiation Nuclear Animal Model Development program.

26 Feb 2024

Innovative therapy targets and destroys leukemia stem cells

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells.

26 Feb 2024

Neuropsychiatric symptoms can be potential predictors of Alzheimer's development

As the years add up, it's common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI).

26 Feb 2024

Natural killer cells lead the charge in cancer treatment innovation

Review synthesizes research on NK cells' role in cancer immunity and their potential in therapeutics through bioengineering, immune checkpoint inhibitors, and cell engagers, highlighting ongoing preclinical and clinical trials.

22 Feb 2024

New immunotherapy target activin receptor 1C shows promise against cancer

Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients' immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Feb 2024

Novel treatment for polycythemia vera shows promise in clinical trial

A novel treatment for polycythemia vera, a potentially fatal blood cancer, demonstrated the ability to control overproduction of red blood cells, the hallmark of this malignancy and many of its debilitating symptoms in a multi-center clinical trial led by the Icahn School of Medicine at Mount Sinai.

21 Feb 2024

Restoring brain pathways to fight opioid addiction

Medical University of South Carolina scientists report in Neuron that they have uncovered a way to restore an opioid-weakened brain pathway in a preclinical model.

20 Feb 2024

Novel treatment strategy shows promise against common liver cancer in children

Hepatoblastoma (HB) is the most common liver cancer in children. Researchers and physicians in the field are concerned because in the last decade HB has been rising rapidly worldwide and has seen the most rapid increase among all pediatric solid tumors.

20 Feb 2024

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

A study led by the Center for Biomaterials and Tissue Engineering of the Universitat Politècnica de València, member of Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, in collaboration with the Instituto de Investigación Sanitaria La Fe and the University of Zaragoza proposes a novel approach to slow neuromuscular degeneration in patients with Amyotrophic Lateral Sclerosis.

20 Feb 2024

Unveiling the role of CD24-Siglec10 axis in tumor immune evasion

Announcing a new article publication for BIO Integration journal. CD24, also known as heat-stable protein, is a highly glycosylated glycosylphosphatidylinositol junction membrane protein.

20 Feb 2024

Study discovers link between a breakdown product from excess niacin and heart disease

Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.

19 Feb 2024

Cellectricon’s expertise in pain research recognized by second EU research grant

BonePainIII project will support an early-stage researcher in quest for novel mechanistic insight and potential therapeutic targets.

From Cellectricon 19 Feb 2024

Innovative immunotherapy targets rare melanoma subtypes

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

16 Feb 2024

City of Hope cures oldest person of blood cancer and achieves HIV remission

City of Hope, one of the largest cancer research and treatment organizations in the United States, treated the oldest person to be cured of a blood cancer and then achieve remission for HIV after receiving a blood stem cell transplant from a donor with a rare genetic mutation.

15 Feb 2024

Preclinical News and Research

Study shows the benefits of locally administered intranasal live-attenuated SARS-CoV-2 vaccine

Optibrium launches a metabolism prediction software platform tailored to DMPK scientists

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

Innovative therapy targets and destroys leukemia stem cells

Neuropsychiatric symptoms can be potential predictors of Alzheimer's development

Natural killer cells lead the charge in cancer treatment innovation

New immunotherapy target activin receptor 1C shows promise against cancer

Novel treatment for polycythemia vera shows promise in clinical trial

Restoring brain pathways to fight opioid addiction

Novel treatment strategy shows promise against common liver cancer in children

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

Unveiling the role of CD24-Siglec10 axis in tumor immune evasion

Study discovers link between a breakdown product from excess niacin and heart disease

Cellectricon’s expertise in pain research recognized by second EU research grant

Innovative immunotherapy targets rare melanoma subtypes

City of Hope cures oldest person of blood cancer and achieves HIV remission

Novel synthetic antibiotic effective against drug-resistant bacteria

Neural prosthetic device successfully used to recall specific memories

Glial fibrillary acidic protein levels pinpoint future dementia risk a decade in advance

Researchers discover a molecular mechanism of noise-induced hearing loss

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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