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Human neuron model identifies potential therapeutic targets for Alzheimer's disease

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain-;a process that drives cognitive decline in Alzheimer's disease and frontotemporal dementia.

5 Apr 2024

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain.

3 Apr 2024

AI analyzes lung ultrasound images to spot COVID-19

Artificial intelligence can spot COVID-19 in lung ultrasound images much like facial recognition software can spot a face in a crowd, new research shows.

20 Mar 2024

Microfluidic chips advance neurodegenerative disease research

Researchers review the role of microfluidic chip models in understanding neurodegenerative diseases, offering insights into the disease mechanisms and potential for drug development through innovative lab-on-a-chip technologies.

14 Mar 2024

New method developed for triggering and imaging seizures in epilepsy patients

Researchers have developed a new method for triggering and imaging seizures in epilepsy patients, offering physicians the ability to collect real-time data to tailor epilepsy surgery.

11 Mar 2024

New research sheds light on how GLP-1 obesity drugs may change food cravings

GLP-1 analog treatments potentially alter food preferences and reduce obesity by decreasing appetite and food consumption, with further research needed for long-term weight maintenance using objective measures.

10 Mar 2024

Neuroscientists uncover brainwave dynamics in memory storage

In the space of just a few seconds, a person walking down a city block might check their phone, yawn, worry about making rent, and adjust their path to avoid a puddle.

8 Mar 2024

Newly identified antibodies target a hard-to-spot region of the influenza virus

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored "dark side" of the neuraminidase (NA) protein head.

1 Mar 2024

Study reveals novel mechanism for longevity of oocytes

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without incurring damage.

20 Feb 2024

Rabies in urban opossums signals health alert in São Paulo

A female White-eared opossum (Didelphis albiventris) found dead in 2021 in Bosque dos Jequitibás Park in the center of Campinas, one of the largest cities in São Paulo state, Brazil, died from rabies meningoencephalitis, according to a group of researchers at the University of São Paulo (USP) and Adolfo Lutz Institute (IAL), the regional reference laboratory, working with health professionals affiliated with public institutions in São Paulo city and Campinas.

16 Feb 2024

Immunocompromised patients show prolonged SARS-CoV-2 infection and unique mutations

study identifies risk factors for prolonged SARS-CoV-2 infection in immunocompromised patients, revealing that B-cell dysfunction, solid organ transplantation, and AIDS lead to longer infections and unique spike mutations.

31 Jan 2024

Infammasomes provide a therapeutic target against human diseases

The structure of inflammasomes and their role in diseases.

9 Jan 2024

New peptide library paves the way for targeting elusive cancer factor MYC

Researchers developed a second-generation NTB bicyclic peptide library, identifying NT-B2R, a peptide that effectively targets MYC, a key factor in most human cancers, demonstrating its potential in inhibiting MYC transcription activities and cancer cell proliferation.

8 Jan 2024

Retinotopic coding bridges perception and memory in the brain, study finds

Study reveals that retinotopic coding in the brain cortex plays a crucial role in processing visual information from the retina, influencing both perception and memory systems.

3 Jan 2024

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Apoptotic cells play key role in hair follicle regression

A new research paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, "Apoptotic cells may drive cell death in hair follicles during their regression cycle."

24 Oct 2023

Large language models perpetuate racial bias in healthcare

The tendency of four commercial LLMs to perpetuate race-based medical misconceptions.

24 Oct 2023

Global surge of highly pathogenic avian influenza H5N1

A recent study published in Nature sheds light on the complex dynamics of highly pathogenic avian influenza (HPAI) H5N1 since 2021, uncovering critical shifts in the virus's behavior and providing insights for more effective mitigation strategies. The research emphasizes the importance of understanding the ecological and virological factors driving the intensified global activity of HPAI H5N1 to better prepare for and manage future outbreaks.

22 Oct 2023

Amsterdam's H-TEAM initiative on track to eradicate HIV with groundbreaking city-centered approach

Amsterdam's H-TEAM initiative has achieved a significant reduction in HIV infections from 2010 to 2022 using a city-centered approach. By combining treatments, including testing, pre-exposure prophylaxis, and stakeholder collaboration, the city has surpassed the UNAIDS 95-95-95 target and is on track to potentially eliminate HIV entirely in the near future.

9 Oct 2023

Compound found to inhibit influenza virus replication by targeting host enzyme

How can the propagation of influenza viruses be stopped? For a new approach in the therapy of influenza infections, Prof. Hiroki Kato from the Institute of Cardiovascular Immunology at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 of the University of Bonn receives an Open Philanthropy grant of 2.2 million US dollars.

9 Oct 2023