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Prostate cancer is the most common non-skin cancer in the United States and the third most common cancer worldwide. More than 1 million men in the United States have prostate cancer and it is the second leading cause of cancer death amongst men after lung cancer. In 2009, an estimated 192,280 new cases are expected to be diagnosed and approximately 27,360 men are expected to die from the disease. Castration-resistant prostate cancer (CRPC) is defined as prostate cancer that continues to grow despite all standard-of-care hormonal (anti-androgen) therapies. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis.
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PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

Prostate-specific antigen (PSA) and other biomarkers are essential tools for diagnosing and monitoring prostate cancer. [More]
Enzyme that cleaves beta carotene may control testosterone levels

Enzyme that cleaves beta carotene may control testosterone levels

An enzyme that converts the dietary carotenoid beta carotene into vitamin A in the body may also regulate testosterone levels and growth of the prostate, a new study found. [More]
UCLA researchers discover how chronic inflammation increases prostate cancer risk

UCLA researchers discover how chronic inflammation increases prostate cancer risk

UCLA researchers have discovered a previously unrecognized type of progenitor cell that, though rare in most regions of the human prostate, is found in uncommonly high numbers in inflamed areas of the gland. [More]
New report estimates global burden of cancer cases and deaths in 2015

New report estimates global burden of cancer cases and deaths in 2015

In 2015, there were an estimated 17.5 million cancer cases around the globe and 8.7 million deaths, according to a new report from the Global Burden of Disease Cancer Collaboration published online by JAMA Oncology. [More]
Novel imaging agent can rapidly and accurately detect metastasis of prostate cancer

Novel imaging agent can rapidly and accurately detect metastasis of prostate cancer

New research demonstrates that a novel imaging agent can quickly and accurately detect metastasis of prostate cancer, even in areas where detection has previously been difficult. [More]
Eindhoven researchers develop patient-friendly method to determine severity of heart failure

Eindhoven researchers develop patient-friendly method to determine severity of heart failure

Methods currently employed to determine the severity of a heart failure are very limited. Researchers at Eindhoven University of Technology and the Catharina Hospital in Eindhoven have therefore developed a method that is very quick, non-invasive, cost-effective and can be performed at the hospital bedside. [More]
Novel imaging technique shows promise to detect, monitor and guide therapy for prostate cancer

Novel imaging technique shows promise to detect, monitor and guide therapy for prostate cancer

An international group of researchers report success in mice of a method of using positron emission tomography scans to track, in real time, an antibody targeting a hormone receptor pathway specifically involved in prostate cancer. [More]
Researchers uncover barriers to recruitment of black men in prostate cancer research studies

Researchers uncover barriers to recruitment of black men in prostate cancer research studies

Black men are three times more likely to develop prostate cancer than other demographics, yet black men are consistently underrepresented in research studies, say researchers from King's College London in a new paper published in ecancermedicalscience. [More]
Research may lead to improved system for early diagnosis and treatment of prostate cancer

Research may lead to improved system for early diagnosis and treatment of prostate cancer

New research coauthored by Brigham Young University researchers may lead to a more accurate system for early detection, diagnosis, and treatment of prostate cancer. [More]
New public-private partnership launches major health effort to reduce cancer in San Francisco

New public-private partnership launches major health effort to reduce cancer in San Francisco

Cancer is the leading cause of death in San Francisco and costs patients, families and taxpayers hundreds of millions of dollars each year. [More]
GW researchers awarded $2.2 million NCI grant to study role of HERVs in cancer

GW researchers awarded $2.2 million NCI grant to study role of HERVs in cancer

George Washington University researchers received a $2.2 million grant from the National Cancer Institute to uncover why certain cancer types increase whereas others are unchanged or even decrease in those with HIV infection. [More]
ZERO's Grow & Give campaign raises awareness and funds to fight prostate cancer

ZERO's Grow & Give campaign raises awareness and funds to fight prostate cancer

This November, facial hair is taking the month by storm with men sprouting 'staches and beards to support their fellow man. For the third consecutive year, ZERO's Grow & Give campaign is dedicated exclusively to raising awareness and funds to fight prostate cancer, a disease that kills an American man every 20 minutes. [More]
Crowdsourcing new prediction tool for better prognosis of metastatic castration-resistant prostate cancer

Crowdsourcing new prediction tool for better prognosis of metastatic castration-resistant prostate cancer

Knowing the likely course of cancer can influence treatment decisions. Now a new prediction model published today in Lancet Oncology offers a more accurate prognosis for a patient's metastatic castration-resistant prostate cancer. [More]
BUSM researchers discover new pathway and protein involved in metastasis of breast cancer

BUSM researchers discover new pathway and protein involved in metastasis of breast cancer

Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread. [More]
Drug approved for other purposes can promote recovery from acute nerve damage, study shows

Drug approved for other purposes can promote recovery from acute nerve damage, study shows

Researchers at the University of Rochester Medical Center believe they have identified a new means of enhancing the body's ability to repair its own cells, which they hope will lead to better diagnosis and treatment of traumatic nerve injuries, like those sustained in car accidents, sports injuries, or in combat. [More]
Scientists show how key protein can be important driver of prostate cancer

Scientists show how key protein can be important driver of prostate cancer

Scientists at The Wistar Institute have demonstrated how a protein called TRAP1 - an important regulator of energy production in healthy and cancerous cells - is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease. [More]
Marker found on aggressive prostate cancer cells could help guide treatments, new research shows

Marker found on aggressive prostate cancer cells could help guide treatments, new research shows

RESEARCHERS have discovered that a marker found on aggressive prostate cancer cells could also be used as a way to guide treatments to the cancer, according to new research presented at the National Cancer Research Institute Cancer Conference in Liverpool. [More]
Tight ‘social networks’ of physicians may help improve patient outcomes, study suggests

Tight ‘social networks’ of physicians may help improve patient outcomes, study suggests

To get the best results for patients, it may pay for their doctors to heed the words of legendary University of Michigan football coach Bo Schembechler: the team, the team, the team. [More]
Caltech researchers develop new technique that increases safety of TCR gene therapy

Caltech researchers develop new technique that increases safety of TCR gene therapy

The human body produces T cells to recognize and fight disease. Each T cell has a unique T cell receptor (or TCR) on its surface that surveils small fragments of proteins presented by other cells. [More]
Second opinions may not reduce overtreatment in prostate cancer, study suggests

Second opinions may not reduce overtreatment in prostate cancer, study suggests

A new analysis indicates that many men with prostate cancer obtain second opinions from urologists before starting treatment, but surprisingly, second opinions are not associated with changes in treatment choice or improvements in perceived quality of prostate cancer care. [More]
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