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Researchers identify molecular switch for protein that causes HER2-positive breast cancer

Researchers identify molecular switch for protein that causes HER2-positive breast cancer

Herceptin has been touted as a wonder drug for women with HER2-positive breast cancer, an aggressive form of the disease that is fueled by excess production of the HER2 protein. However, not all of these patients respond to the drug, and many who do respond eventually acquire resistance. [More]
TSRI study provides new insight into preventing diseases that cause vision loss in adults

TSRI study provides new insight into preventing diseases that cause vision loss in adults

A new study from scientists at The Scripps Research Institute shows that nerve cells and blood vessels in the eye constantly "talk" to each other to maintain healthy blood flow and prevent disease. [More]
Researchers pinpoint new mechanism responsible for malaria progression

Researchers pinpoint new mechanism responsible for malaria progression

A team of researchers from four universities has pinpointed one of the mechanisms responsible for the progression of malaria, providing a new target for possible treatments. [More]
Discovery of molecular reset button for internal body clock could help treat different disorders

Discovery of molecular reset button for internal body clock could help treat different disorders

An international team of scientists has discovered what amounts to a molecular reset button for our internal body clock. Their findings reveal a potential target to treat a range of disorders, from sleep disturbances to other behavioral, cognitive, and metabolic abnormalities, commonly associated with jet lag, shift work and exposure to light at night, as well as with neuropsychiatric conditions such as depression and autism. [More]
Gladstone researchers identify way to prevent MS development in mice

Gladstone researchers identify way to prevent MS development in mice

Scientists from the Gladstone Institutes have discovered a way to prevent the development of multiple sclerosis (MS) in mice. Using a drug that blocks the production of a certain type of immune cell linked to inflammation and autoimmunity, the researchers successfully protected against the onset of MS in an animal model of the disease. [More]
Study suggests that inhibiting FOXO1 protein could speed diabetic wound healing

Study suggests that inhibiting FOXO1 protein could speed diabetic wound healing

A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high, according to a study in The Journal of Cell Biology. The role reversal helps explain why wounds heal slowly in people with diabetes. [More]
Vermillion reports expanded medical policy coverage of OVA1 test

Vermillion reports expanded medical policy coverage of OVA1 test

Vermillion, Inc., a bio-analytical solutions company focused on gynecologic disease, today announced expanded medical policy coverage of its OVA1 test, following Blue Cross Blue Shield of Michigan's recent decision to include OVA1 in its medical policy guidelines. [More]
TAXIS Pharmaceuticals' TXA709 compound shows promise in combating antibiotic resistance

TAXIS Pharmaceuticals' TXA709 compound shows promise in combating antibiotic resistance

TAXIS Pharmaceuticals, a drug-discovery company focused on developing a new class of antibiotic agents to treat life-threatening, multidrug-resistant bacterial infections, today announced the presentation of data demonstrating the promise of its lead clinical candidate, TXA709, in combating antibiotic resistance. [More]
aTyr's Resolaris granted FDA Orphan Drug Designation for treatment of FSHD

aTyr's Resolaris granted FDA Orphan Drug Designation for treatment of FSHD

aTyr Pharma, a biotherapeutics company engaged in the discovery and development of Physiocrine-based therapeutics to address rare diseases, announced today that Resolaris has been granted Orphan Drug Designation by the U.S. Food and Drug Administration for the treatment of facioscapulohumeral muscular dystrophy (FSHD). [More]
OncoGenex terminates agreement with Teva, regains rights to custirsen

OncoGenex terminates agreement with Teva, regains rights to custirsen

OncoGenex Pharmaceuticals, Inc. today announced that its wholly owned subsidiary, OncoGenex Technologies Inc., executed a termination agreement with Teva Pharmaceuticals Ltd. under which OncoGenex will regain rights to custirsen, an investigational compound currently in Phase 3 clinical development as a treatment for prostate and lung cancers. [More]
ISSCR calls for moratorium on human germline genome editing attempts in clinical practice

ISSCR calls for moratorium on human germline genome editing attempts in clinical practice

In response to an article published by Chinese scientists describing research that used gene editing technologies in human embryos, the International Society for Stem Cell Research has again called for a moratorium on attempts at human clinical germline genome editing while extensive scientific analysis of the potential risks is conducted, along with broad public discussion of the societal and ethical implications. [More]
Vanderbilt biologists explore how electrochemical connections form at molecular and cellular level

Vanderbilt biologists explore how electrochemical connections form at molecular and cellular level

Every time you make a memory, somewhere in your brain a tiny filament reaches out from one neuron and forms an electrochemical connection to a neighboring neuron. [More]
Scientists discover new way to control inflammation during worm infections and allergies

Scientists discover new way to control inflammation during worm infections and allergies

Research from The University of Manchester is bringing scientists a step closer to developing new therapies for controlling the body's response to allergies and parasitic worm infections. [More]
Findings could help design tailor-made drugs to treat blood pressure

Findings could help design tailor-made drugs to treat blood pressure

One in three Americans has high blood pressure, a long-term constriction of arteries that can lead to coronary heart disease, heart failure and stroke. [More]
Researchers identify potential treatment target for fragile X carriers

Researchers identify potential treatment target for fragile X carriers

Fragile X syndrome, an inherited cause of autism and intellectual disability, can have consequences even for carriers of the disorder who don't have full-blown symptoms. [More]
Study explores innovative approach to identifying successful treatment for HER2+ breast cancer

Study explores innovative approach to identifying successful treatment for HER2+ breast cancer

Ahmad M. Khalil, PhD, knew the odds were against him -- as in thousands upon thousands to one. Yet he and his team never wavered from their quest to identify the parts of the body responsible for revving up one of the most aggressive forms of breast cancer, HER2+. This month in Breast Cancer Research and Treatment, Khalil and his colleagues at Case Western Reserve University proved the power of persistence; from a pool of more than 30,000 possibilities, they found 38 genes and molecules that most likely trigger HER2+ cancer cells to spread. [More]
New method could help scientists spot source of disease-causing mutations in enhancers

New method could help scientists spot source of disease-causing mutations in enhancers

A new technique that identifies how genes are controlled could help scientists spot errors in the genetic code which trigger disease, a study suggests. [More]
Lilly receives fourth FDA approval for CYRAMZA (ramucirumab)

Lilly receives fourth FDA approval for CYRAMZA (ramucirumab)

Eli Lilly and Company has received its fourth U.S. Food and Drug Administration approval for CYRAMZA (ramucirumab). CYRAMZA (ramucirumab injection 10 mg/mL solution) is now also indicated in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil) chemotherapy for the treatment of patients with metastatic colorectal cancer (mCRC) with disease progression on or after prior therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine. [More]
New research shows how fat controls energy levels in the brain

New research shows how fat controls energy levels in the brain

An enzyme secreted by the body's fat tissue controls energy levels in the brain, according to new research at Washington University School of Medicine in St. Louis. The findings, in mice, underscore a role for the body's fat tissue in controlling the brain's response to food scarcity, and suggest there is an optimal amount of body fat for maximizing health and longevity. [More]
Fruit fly study shows that extra sleep helps the brain overcome neurological defects

Fruit fly study shows that extra sleep helps the brain overcome neurological defects

Many studies have linked more sleep to better memory, but new research in fruit flies demonstrates that extra sleep helps the brain overcome catastrophic neurological defects that otherwise would block memory formation, report scientists at Washington University School of Medicine in St. Louis. [More]
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