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TSRI scientists develop new method to enhance drug discovery and protein research

TSRI scientists develop new method to enhance drug discovery and protein research

A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins. [More]
High blood levels of protein may help preserve kidney function, study suggests

High blood levels of protein may help preserve kidney function, study suggests

Higher blood levels of a protein called klotho may help preserve kidney function, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. [More]
Study reveals mechanism for illness-induced sleepiness in humans and animals

Study reveals mechanism for illness-induced sleepiness in humans and animals

It's well known that humans and other animals are fatigued and sleepy when sick, but it's a microscopic roundworm that's providing an explanation of how that occurs, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania. [More]
Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer. [More]
Mutations in gene that enables memories, sense of direction can contribute to schizophrenia symptoms

Mutations in gene that enables memories, sense of direction can contribute to schizophrenia symptoms

Mutations in a gene that should enable memories and a sense of direction instead can result in imprecise communication between neurons that contributes to symptoms of schizophrenia, scientists report. [More]
Influenza experts examine evolution of avian disease

Influenza experts examine evolution of avian disease

Few influenza viruses are as widespread and adaptable as avian influenza viruses, and scientists are not entirely sure why. [More]
RIT research explores impact of shear stress on cells moving through blood vessels

RIT research explores impact of shear stress on cells moving through blood vessels

How do cells and protein molecules respond to stress as they travel through blood vessels? Could resulting changes to these biological components impact how diseases are spread? [More]
Scientists harness rabies viruses for assessing connectivity of nerve cell transplants

Scientists harness rabies viruses for assessing connectivity of nerve cell transplants

Scientists under the leadership of the University of Bonn have harnessed rabies viruses for assessing the connectivity of nerve cell transplants: coupled with a green fluorescent protein, the viruses show where replacement cells engrafted into mouse brains have connected to the host neural network. [More]
Study shows structural impact of membrane lipids on medically relevant serotonin transporters

Study shows structural impact of membrane lipids on medically relevant serotonin transporters

Neurotransmitter transporters are some of the most popular transport proteins in research as they play a major role in the processing of signals in the brain. A joint study by TU Wien and the Medical University of Vienna has now successfully demonstrated for the first time the structural impact of membrane lipids on medically relevant serotonin transporters. [More]
Endogenous peptide inhibits atherosclerosis by reducing cholesterol levels

Endogenous peptide inhibits atherosclerosis by reducing cholesterol levels

Cells of the innate immune system that play an important role in development of atherosclerosis contain a protein that reduces levels of cholesterol in mice - and thus helps to inhibit or mitigate the disease. [More]
Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra LLC, a biotechnology company discovering therapies for Alzheimer’s disease and Parkinson’s disease announced the publication of the article “Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease” in Scientific Reports, a peer-reviewed journal of the Nature Publishing Group. [More]
Researchers uncover structure of cancer cell receptor protein that paves way for drug development

Researchers uncover structure of cancer cell receptor protein that paves way for drug development

A team of researchers from Case Western Reserve University School of Medicine has helped uncover the elusive structure of a cancer cell receptor protein that can be leveraged to fight disease progression. [More]
Study identifies molecular signals that maintain nerve cell structures in the adult brain

Study identifies molecular signals that maintain nerve cell structures in the adult brain

Humans and other vertebrates depend on a portion of the brain called the hippocampus for learning, memory and their sense of location. Nerve cell structures in the adult hippocampus are sustained by factors whose identities have remained largely mysterious so far. [More]
Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

Researcher awarded $1.8 million grant to explore how chronic stress impacts cancer development

A five-year, $1.8 million grant (R01CA203965) from the National Cancer Institute awarded to Rutgers Cancer Institute of New Jersey resident research member Wenwei Hu, PhD, will support research to further elucidate the mechanisms behind the most frequently mutated gene in human tumors - p53. [More]
Researchers uncover new pathway in the body that stimulates liver repair

Researchers uncover new pathway in the body that stimulates liver repair

A team of Michigan State University researchers, led by James Luyendyk in the College of Veterinary Medicine, has uncovered a new pathway in the body that stimulates liver repair. [More]
Research finding provides new target for regulating cell division

Research finding provides new target for regulating cell division

Modern genome sequencing methods used to measure the efficiency of synthesis of individual protein during cell division has found that the enzymes that make lipids and membranes were synthesized at much greater efficiency when a cell is ready to split. [More]
Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Neurodevelopmental disorders like autism very likely have their origin at the dawn of life, with the emergence of inappropriate connectivity between nerve cells in the brain. [More]
Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

Researchers uncover how stress hormone prevents digestive enzymes from damaging pancreas

UT Southwestern Medical Center researchers have uncovered the mechanism by which the stress hormone FGF21 keeps digestive enzymes from damaging the pancreas. [More]
Stem cell research offers alternative view of cancer metastasis

Stem cell research offers alternative view of cancer metastasis

Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumour cells, according to observations by scholars at the Biomedical Research Centre at the University of Salford. [More]
Scientists discover adverse, unpredictable side effects of approved MS therapy

Scientists discover adverse, unpredictable side effects of approved MS therapy

The multiple sclerosis (MS) therapy alemtuzumab can trigger severe, unpredictable side effects. [More]
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