Protein Aggregation News and Research

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Researchers find link between interferon, neuroinflammation and synapse loss in Alzheimer's

When immunologist Dr. Wei Cao joined Baylor College of Medicine three-and-a-half years ago, her first project was to investigate how inflammation contributes to Alzheimer's disease.

5 Mar 2020

Researchers discover glial cells that control stress response, extend lifespan in worms

While many of us worry about proteins aggregating in our brains as we age and potentially causing Alzheimer's disease or other types of neurodegeneration, we may not realize that some of the same proteins are aggregating in our muscles, setting us up for muscle atrophy in old age.

23 Feb 2020

Study uncovers molecular mechanism that triggers a rare type of muscular dystrophy

A study led by the IBB-UAB has identified the molecular mechanism through which a protein, when carrying genetic mutations associated with a rare disease known as limb-girdle muscular dystrophy, type 1G, accelerates its tendency to form amyloid fibrils and finally triggers the appearance of the disease.

29 Jan 2020

Informative white paper demonstrates benefits of novel EAF4 technology

An informative white paper from Postnova Analytics demonstrates how its novel Electrical and Asymmetrical Field Flow Fractionation (EAF4) technology can be used to separate a wide variety of nano-sized materials while simultaneously determining surface charge.

From Postnova Analytics 21 Jan 2020

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

Northwestern scientists receive $3.1 million grant to investigate drug therapies for ALS

Two Northwestern University scientists have received a $3.1 million grant from the National Institute on Aging to collaborate and investigate drug therapies for amyotrophic lateral sclerosis.

18 Aug 2019

Researchers identify possible role of polyphosphate in dialysis-related amyloidosis

Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates—called amyloid fibrils—in joints, tissues and organs.

8 Jul 2019

Protein Clumps In ALS Neurons Provide Potential Target For New Therapies

Amyotrophic lateral sclerosis is a neurological condition that affects motor neurons -- the nerve cells that control breathing and muscles.

2 Jul 2019

EAF2000 advances complex charged molecule studies

Postnova Analytics reports on growing use of its pioneering EAF2000 system to separate and characterize complex proteins, antibodies and viruses as well as charged nanoparticles, colloids and polymers.

From Postnova Analytics 10 Jun 2019

Powerful separation technique opens door to characterizing complex samples

From Postnova Analytics 31 May 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

The most recent developments by Wyatt in their instrumentation and software have made the full potential of FFF accessible to a wider user base. In this interview, Kim R. Williams and Christoph Johann talk to News-Medical and Life Sciences about the technologies and their research.

From Waters | Wyatt Technology 27 Mar 2019

New method detects potentially disease-causing forms of proteins using fluorescence

A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations.

14 Feb 2019

RNAs are involved in protein aggregation and neurodegenerative diseases, research reveals

New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates. If cells cannot clear these away, they become toxic and prevent cells working properly.

8 Feb 2019

Antibiotic could protect against age-related brain diseases

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.

28 Nov 2018

Researchers find molecule that halts, reverts neurodegeneration caused by Parkinson's disease

The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibers responsible for the onset of Parkinson's disease, and reverts the neurodegeneration caused by the disease.

25 Sep 2018

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell.

17 Sep 2018