Proteinuria News and Research

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Proteinuria, also sometimes referred to as albuminuria or urine albumin, is a health condition characterized by an abnormal concentration of protein in the urine.

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis (FSGS), a rare disease in which scar tissue forms on the parts of the kidneys that filter waste from the blood, can significantly slow declines in kidney function and extend time before patients' kidneys fail, a new analysis by a Children's National Hospital researcher and her colleagues shows.

10 Aug 2020

Severity of COVID-19 linked to heparanase activity and heparan sulfate levels

Researchers at Radboud University Medical Center in the Netherlands reported an increase of heparanase activity and heparan sulfate levels in the plasma of patients with coronavirus disease (COVID-19), which was also associated with the severity of the condition – suggesting, in turn, potential treatment utility of low molecular weight heparins. The paper is currently available on the medRxiv* preprint server.

16 Jun 2020

Cell signaling pathway could treat chronic kidney disease and other medical conditions

Scientists have discovered an important cell signaling pathway in the kidney which if stopped, could hold the key to treating chronic kidney disease as well as other deadly conditions, including heart attack and stroke.

16 Jun 2020

Indirect viral infection of the kidneys by SARS-CoV-2-induced inflammatory reaction

SARS-CoV-2-associated acute kidney injury is not uncommon. Many hospitalized COVID-19 patients - as many as 80% of critically ill COVID-19 patients, according to a current study - develop acute kidney injury, but without requiring dialysis in most cases. Proteinuria and hematuria are present in about half the cases.

8 Jun 2020

SARS-CoV-2 infection causes specific kidney proximal tubular injury

SARS-CoV-2-associated acute kidney injury (AKI) is one of the more frequently encountered organ involvements in COVID-19 - in as many as 80% of critically ill patients, according to a recent study.

8 Jun 2020

Acute kidney injury in intensive-care COVID-19 patients

71 patients with severe lung injury were admitted to four intensive care units at Bordeaux University Hospital and their data were collected and evaluated over a period of six weeks (March/April 2020). AKI was defined using KDIGO criteria and ADQI according to the Acute Disease Quality Initiative (ADQI) 16 workgroup.

8 Jun 2020

Kidney impairment significantly higher among hospitalized COVID-19 patients

Germany was not hit as hard by the SARS-CoV-2 pandemic as many other European countries. The reason for this is that the wave of infection reached Germany later, that the authorities were warned by the situation in Italy and Spain and at an early stage ordered a lockdown and conducted extensive testing.

5 Jun 2020

Capillary leakage important in COVID-19 respiratory distress

Now, a new study published on the preprint server medRxiv reports the pivotal role played by protein leakage through lung capillaries and promotes the use of serum albumin as a biomarker of disease progression and severity.

24 May 2020

Urine protein levels can help identify patients at higher risk for future loss of kidney function

High levels of protein in a patient's urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.

28 Jan 2020

Disease-modifying therapy for Alport syndrome still remains an unmet need

Alport syndrome is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure.

13 Jun 2019

More care is needed for patients after kidney transplantations, reports research

Patients with chronic kidney disease, and dialysis patients especially, have a significantly higher cardiovascular morbidity and mortality than healthy people. Kidney transplantation is the best renal replacement therapy available.

19 Apr 2019

Living transplant donors also need long-term monitoring to prevent adverse events

While organ transplant recipients receive continual care as the end-stage treatment to their condition, attention also should be given to living donors, who can suffer from hypertension, diabetes and other disorders after donation, according to a study by researchers at UC San Francisco.

11 Apr 2019

RNAi therapy shown to alleviate preeclampsia in animal model

Researcher have used a small interfering RNA (siRNA) to reduce preeclampsia symptoms in an animal model. The approach could provide a new way of treating preeclampsia in humans.

19 Nov 2018

Scientists identify 'skeleton key' for congenital kidney disease research

Scientists in Japan have found a 'skeleton key' for congenital kidney disease research. Using iPS cells generated from the skin cells of a patient with a nephrin mutation, Kumamoto University scientists have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease.

31 Oct 2018

FDA approves new treatment for people with hairy cell leukemia

AstraZeneca and MedImmune, its global biologics research and development arm, announced today that the US Food and Drug Administration has approved LUMOXITI (moxetumomab pasudotox-tdfk) for the treatment of adult patients with relapsed or refractory hairy cell leukemia who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.

14 Sep 2018

Inhibiting immune-regulating molecule could prevent or reverse renal injury, research shows

Special cells called podocytes aid the kidneys as they clean the blood and balance the body's fluid levels. Podocytes filter blood as it passes through the cells' foot-like projections they are named for, interwoven like the fingers of clasped hands.

11 Jul 2018

Study suggests proteinuria lowering as important target in managing pediatric CKD

In a study of children with chronic kidney disease, blood pressure medications reduced protein excretion in the urine, which was linked with a lower risk of disease progression.

22 Jun 2018

Data-driven tool defines risk stages for children with chronic kidney disease

Experts in pediatric kidney disease have published a new staging system to help doctors better predict the length of time until a child with chronic kidney disease (CKD) will need to undergo a kidney transplant or start receiving dialysis. Although this type of prognostic guide exists for adults, this is the first such tool specific to children.

10 Apr 2018

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia. In patients who have undergone chemotherapy and radiation, a small number of cancer cells can remain in the bloodstream and allow the malignancy to recur.

3 Apr 2018

Reduced risk of heart disease for mothers who breastfeed

According to a new study, women who breastfeed their babies for a minimum of 6 months after giving birth have a reduced risk of heart disease in later life.

1 Mar 2018

Proteinuria News and Research

Further Reading

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Severity of COVID-19 linked to heparanase activity and heparan sulfate levels

Cell signaling pathway could treat chronic kidney disease and other medical conditions

Indirect viral infection of the kidneys by SARS-CoV-2-induced inflammatory reaction

SARS-CoV-2 infection causes specific kidney proximal tubular injury

Acute kidney injury in intensive-care COVID-19 patients

Kidney impairment significantly higher among hospitalized COVID-19 patients

Capillary leakage important in COVID-19 respiratory distress

Urine protein levels can help identify patients at higher risk for future loss of kidney function

Disease-modifying therapy for Alport syndrome still remains an unmet need

More care is needed for patients after kidney transplantations, reports research

Living transplant donors also need long-term monitoring to prevent adverse events

RNAi therapy shown to alleviate preeclampsia in animal model

Scientists identify 'skeleton key' for congenital kidney disease research

FDA approves new treatment for people with hairy cell leukemia

Inhibiting immune-regulating molecule could prevent or reverse renal injury, research shows

Study suggests proteinuria lowering as important target in managing pediatric CKD

Data-driven tool defines risk stages for children with chronic kidney disease

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

Reduced risk of heart disease for mothers who breastfeed

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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