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The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Researchers develop a novel plasma proteome-based test for early detection of multiple cancers, achieving high accuracy in identifying low-abundance protein biomarkers.

14 Jan 2024

Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

Chia genome sequenced, revealing potential health benefits

In a recent study published in Frontiers in Plant Science, researchers presented the assembly of the chia reference genome.

18 Dec 2023

Researchers report progress in the search for more accurate blood markers for acute kidney injury

Using cells from kidney biopsies, Johns Hopkins Medicine, researchers report progress in the search for more accurate and easier-to-obtain markers to help predict, manage and assess treatment of acute kidney injury (AKI).

14 Dec 2023

Is your body out of sync? Study finds organs age at varying rates

Research uncovers that human organs age at varying rates, with some showing accelerated aging compared to chronological age, significantly impacting overall health and disease risk. The study used advanced blood plasma proteomics to analyze organ-specific aging in nearly 5,700 adults, linking it to increased risks of heart failure and Alzheimer's disease.

7 Dec 2023

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

7 Dec 2023

What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data

Researchers performed a proteomic analysis to identify serologic indicators of organ aging and disease.

7 Dec 2023

Researchers evaluate possible mitochondrial factors in Alzheimer's pathogenesis

A group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the pathogenesis of Alzheimer's disease (AD).

5 Dec 2023

Advances in understanding and detecting Alzheimer's disease

Researchers are making strides toward understanding and detecting Alzheimer's disease in its earliest stages, when interventions may be most effective at slowing the progress of the disease.

13 Nov 2023

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

In a comprehensive multi-ancestry GWAS meta-analysis, researchers identified 451 risk variants for prostate cancer, including 187 new variants, demonstrating the utility of such studies across diverse populations. This analysis not only increased understanding of genetic risk factors but also differentiated between aggressive and non-aggressive prostate cancer types, underscoring the potential of genetic risk scoring in guiding screening and early detection strategies.

12 Nov 2023

Researchers announce a new genetic classification system for gastric cancer

Professor Sang Cheul Oh of the Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Professor Sang‑Hee Kang of the Department of Surgery, Korea University's Guro Hospital, and Professor Sun Young Yim of the Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine announced a new genetic classification system for gastric cancer by a multicenter study with the University of Texas MD Anderson Cancer Center.

6 Nov 2023

A comprehensive database developed to help understand the basis of protein aggregation

Researchers at the IBB-UAB have developed the most comprehensive database available to date to help understand the basis of protein aggregation, a phenomenon associated with aging and several pathologies.

3 Nov 2023

Researchers discover new mechanism of cancer treatment resistance

A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators.

2 Nov 2023

How one gene shakes up our understanding of male infertility

The study investigates the role of the ACTL7B gene in sperm formation using genetically modified mice and finds that deficiencies in this gene lead to failed spermatogenesis and structural sperm abnormalities. Given the gene's similarity in humans, the findings suggest ACTL7B could serve as a potential biomarker for male infertility.

31 Oct 2023

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature."

31 Oct 2023

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.

24 Oct 2023

Saliva test breakthrough: Early detection for ectopic pregnancies on the horizon

Salivary proteins may offer early detection for ectopic pregnancies, potentially saving maternal lives through a non-invasive diagnostic approach. The study identifies specific proteins that are prominently present in ruptured ectopic pregnancy cases, highlighting the potential for developing a saliva-based diagnostic kit.

9 Oct 2023

Unlocking the future of cancer care: Overcoming challenges in personalized neoantigen vaccine development

Challenges associated with the development and design of neoantigen cancer vaccines.

5 Oct 2023

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.

20 Sep 2023

DeepMind develops new tool to predict pathogenicity of missense variants

DeepMind is releasing AlphaMissense, a tool researchers can use to learn more about the effects that missense mutations – which make up the majority of "variants of uncertain significance" – have on disease.

19 Sep 2023

Proteome News and Research

Novel blood test shows promise in detecting early-stage cancers with high accuracy

Glioblastoma tumor cells mimic neurons to evade treatment

Chia genome sequenced, revealing potential health benefits

Researchers report progress in the search for more accurate blood markers for acute kidney injury

Is your body out of sync? Study finds organs age at varying rates

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

What's my age again? Predicting disease and aging effects by studying organ aging using plasma proteomics data

Researchers evaluate possible mitochondrial factors in Alzheimer's pathogenesis

Advances in understanding and detecting Alzheimer's disease

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

Researchers announce a new genetic classification system for gastric cancer

A comprehensive database developed to help understand the basis of protein aggregation

Researchers discover new mechanism of cancer treatment resistance

How one gene shakes up our understanding of male infertility

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Saliva test breakthrough: Early detection for ectopic pregnancies on the horizon

Unlocking the future of cancer care: Overcoming challenges in personalized neoantigen vaccine development

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

DeepMind develops new tool to predict pathogenicity of missense variants

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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