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Genkyotex’s GKT137831 reverses lung fibrosis in new model of idiopathic pulmonary fibrosis

Genkyotex, the leading developer of selective NOX enzyme inhibitors, announced today the publication of data showing that GKT137831, a first in class NOX1 and 4 inhibitor, was able to reverse lung fibrosis associated with aging in a new model of idiopathic pulmonary fibrosis. [More]
Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

The body clock's natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases. [More]
STC Life and 97.7 B&H Clinic successfully treat pulmonary fibrosis patient

STC Life and 97.7 B&H Clinic successfully treat pulmonary fibrosis patient

Stem cell research institute of STC Life Co., Ltd. (Chairman: KYE HO LEE) and 97.7 B&H Clinic (Representative Doctor: WON JU JUNG) successfully finished mesenchymal stem cell therapy for the pulmonary fibrosis patient who visited Korea from Calgary, Canada. [More]
Fibrotech successfully completes Phase Ia trial of anti-fibrotic compound FT011

Fibrotech successfully completes Phase Ia trial of anti-fibrotic compound FT011

Fibrotech, an Australian biopharmaceutical company developing a new class of drugs to prevent a massive health burden associated with fibrosis, today announced that its lead anti-fibrotic compound FT011 has successfully completed a Phase Ia trial in healthy volunteers demonstrating safety and tolerability up to doses of 1000mg. [More]

3D scaffolds bring hope for lung regeneration

In end-stage lung disease, transplantation is sometimes the only viable therapeutic option, but organ availability is limited and rejection presents an additional challenge. [More]
Research reveals 2 key mechanisms of oxidative stress regulation

Research reveals 2 key mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells. [More]
Idiopathic pulmonary fibrosis could soon be diagnosed without the need for surgical lung biopsy

Idiopathic pulmonary fibrosis could soon be diagnosed without the need for surgical lung biopsy

People who have suspected idiopathic pulmonary fibrosis without typical patterns on high resolution computed tomography scans could in future be spared the substantial risks of lung biopsy and be given a confident diagnosis of IPF based on clinical and radiological findings alone, according to new research published in The Lancet Respiratory Medicine. [More]

Cedars-Sinai research team receives grant to develop treatment for idiopathic pulmonary fibrosis

​A Cedars-Sinai research team led by Paul W. Noble, MD, chair of the Department of Medicine and director of the Women's Guild Lung Institute, has been awarded $628,816 by California's stem cell agency to develop a treatment for idiopathic pulmonary fibrosis, a deadly disease that destroys the lungs and damages other vital organs. [More]
Boehringer Ingelheim, DCRI partner to uncover insights into idiopathic pulmonary fibrosis

Boehringer Ingelheim, DCRI partner to uncover insights into idiopathic pulmonary fibrosis

Boehringer Ingelheim Pharmaceuticals, Inc. and Duke Clinical Research Institute have formed a unique collaborative relationship to uncover insights into idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease. [More]

Pulmonary Fibrosis Foundation selects UofL for newly established Care Center Network

The University of Louisville is one of nine pilot sites selected by the Pulmonary Fibrosis Foundation for its newly established Care Center Network and the PFF Patient Registry program. Rafael Perez, M.D., director of the UofL Interstitial Lung Disease program in the Division of Pulmonary, Critical Care & Sleep Disorders Medicine, will lead the UofL site. [More]
Idiopathic pulmonary fibrosis (IPF) and herpesvirus saimiri: an interview with Elazar Rabbani, Chief Executive Officer of Enzo

Idiopathic pulmonary fibrosis (IPF) and herpesvirus saimiri: an interview with Elazar Rabbani, Chief Executive Officer of Enzo

Pulmonary fibrosis is a condition where fibrotic or scarred tissue progressively develops in the lungs. In some cases the particular cause is known but in others it remains unknown and is given the term “idiopathic”. [More]

FibroGen starts patient enrollment in FG-3019 Phase 2 study for idiopathic pulmonary fibrosis treatment

FibroGen, Inc., announced today that patient enrollment has started in a new Phase 2 clinical study of FG-3019 in patients who suffer from idiopathic pulmonary fibrosis. [More]
ATS Foundation, American Lung Association to co-fund $80,000 grant to support HPS research

ATS Foundation, American Lung Association to co-fund $80,000 grant to support HPS research

The American Thoracic Society Foundation and the American Lung Association announced today that they are co-funding an $80,000 grant that will support important research into the mechanisms underlying Hermansky-Pudlak syndrome, a rare inherited disease which affects a number of organs including the lungs. [More]
UCD Conway Institute researchers identify potential biomarker of idiopathic pulmonary fibrosis

UCD Conway Institute researchers identify potential biomarker of idiopathic pulmonary fibrosis

Researchers in UCD Conway Institute have identified a potential biomarker of rapidly progressive pulmonary fibrosis and pinpointed a defective molecular function as a potential therapeutic target. [More]

6MWT wording change could enhance serial utility

Researchers have found that the distance patients cover during the 6-minute walk test depends on the instructions they are given, indicating that changing the current protocol may enhance the accuracy and reproducibility of the test. [More]
MUC5B protein plays key role in many lung-related ailments

MUC5B protein plays key role in many lung-related ailments

An international team of researchers has zeroed in on a protein that plays a key role in many lung-related ailments, from seasonal coughing and hacking to more serious diseases such as MRSA infections and cystic fibrosis. [More]
Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

Oxygen levels play critical role in determining effectiveness of anti-inflammatory drugs

A new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs. [More]
Scientists transform human stem cells into functional lung and airway cells

Scientists transform human stem cells into functional lung and airway cells

For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center researchers, has significant potential for modeling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation. [More]
FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

FibroGen presents China-based Phase 2 study data of roxadustat for treatment of CKD patients

FibroGen, Inc. (FibroGen), today announced that data from a China-based Phase 2 study of roxadustat (FG-4592), a first-in-class oral compound in late stage development for the treatment of anemia associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD), were presented in an oral session at the 2013 American Society of Nephrology (ASN) Kidney Week in Atlanta, Georgia. [More]

Researchers identify new way to intervene in molecular, cellular cascade that causes fibrosis

A team of scientists that includes Saint Louis University researchers has identified a new way to intervene in the molecular and cellular cascade that causes fibrosis - a condition where the body's natural process of forming scars for wound healing goes into overdrive and causes diseases. [More]