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Resveratrol is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Several experiments suggest that it triggers mechanisms that counteract aging-related effects in animals.
Smaller doses of resveratrol more effective at preventing bowel cancer

Smaller doses of resveratrol more effective at preventing bowel cancer

Resveratrol, a chemical found in red grapes, is more effective in smaller doses at preventing bowel cancer in mice than high doses, according to new research published today (Wednesday) in the journal Science Translational Medicine. [More]
Resveratrol and quercetin may improve efficacy of existing chemotherapeutic cancer drug

Resveratrol and quercetin may improve efficacy of existing chemotherapeutic cancer drug

Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment, primarily by improving the efficacy and potential use of an existing chemotherapeutic cancer drug. [More]
Two physician-scientists in search for better Alzheimer's disease treatment

Two physician-scientists in search for better Alzheimer's disease treatment

Two of the nation's leading physician-scientists in the search to better understand and treat Alzheimer's disease - William Mobley, MD, PhD, and Michael Rafii, MD, PhD - have been named interim co-directors of the Alzheimer's Disease Cooperative Study (ADCS), a major initiative formed in 1991 as a cooperative agreement between the National Institute on Aging (NIA) and the University of California, San Diego. [More]
WSU research provides new strategies for prevention, treatment of obesity

WSU research provides new strategies for prevention, treatment of obesity

Washington State University scientists have shown that berries, grapes and other fruits convert excess white fat into calorie-burning "beige" fat, providing new strategies for the prevention and treatment of obesity. [More]
Study reveals molecular basis for endocrine therapy-resistant breast cancer

Study reveals molecular basis for endocrine therapy-resistant breast cancer

Mitsuyoshi Nakao, Director of the Institute of Molecular Embryology and Genetics in Kumamoto University and Associate Professor Noriko Saitoh revealed that a cluster of defined, non-coding RNAs are mechanistically involved in endocrine therapy resistance in human breast cancer cells. Furthermore, resveratrol, a kind of polyphenol, was found to repress these RNAs and inhibit the proliferative activity of breast cancer cells which had acquired resistance. [More]
Gladstone researchers identify way to prevent MS development in mice

Gladstone researchers identify way to prevent MS development in mice

Scientists from the Gladstone Institutes have discovered a way to prevent the development of multiple sclerosis (MS) in mice. Using a drug that blocks the production of a certain type of immune cell linked to inflammation and autoimmunity, the researchers successfully protected against the onset of MS in an animal model of the disease. [More]
Study: Plant compounds can help prevent liver damage during menopause

Study: Plant compounds can help prevent liver damage during menopause

Women going through menopause often struggle with weight gain that results when their estrogen levels drop, and many turn to weight-loss supplements to help them shed those extra pounds. But those supplements may cause an accumulation of fat in the liver and a potentially life-threatening condition called non-alcoholic fatty liver disease. [More]
Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

A compound found in common foods such as red grapes and peanuts may help prevent age-related decline in memory, according to new research published by a faculty member in the Texas A&M Health Science Center College of Medicine. [More]
Resveratrol activates ancient stress response in human cells, shows study

Resveratrol activates ancient stress response in human cells, shows study

Scientists at The Scripps Research Institute (TSRI) have found that resveratrol, the red-wine ingredient once touted as an elixir of youth, powerfully activates an evolutionarily ancient stress response in human cells. [More]
Researchers examining new antioxidant-based therapeutic approaches to hypertension

Researchers examining new antioxidant-based therapeutic approaches to hypertension

High blood pressure affects more than 70 million Americans and is a major risk factor for stroke, heart failure and other renal and cardiovascular diseases. Two University of Houston College of Pharmacy researchers are examining the role of intrinsic antioxidant pathways in mitigating hypertension. [More]
Resveratrol in red wine inhibits formation of inflammatory factors that activate cardiovascular diseases

Resveratrol in red wine inhibits formation of inflammatory factors that activate cardiovascular diseases

A natural substance present in red wine, resveratrol, inhibits the formation of inflammatory factors that trigger cardiovascular diseases. This has been established by a research team at the Department of Pharmacology of the University Medical Center of Johannes Gutenberg University of Mainz working in collaboration with researchers of the Friedrich Schiller University in Jena and the University of Vienna. [More]
Resveratrol in red wine may prevent cancer

Resveratrol in red wine may prevent cancer

Alcohol use is a major risk factor for head and neck cancer. But an article published in the November issue of the journal Advances in Experimental Medicine and Biology shows that the chemical resveratrol found in grape skins and in red wine may prevent cancer as well. [More]
AGA's journals highlight important updates into treatments for cirrhosis, NAFLD

AGA's journals highlight important updates into treatments for cirrhosis, NAFLD

Cirrhosis and nonalcoholic fatty liver disease (NAFLD) are two serious liver conditions with limited pharmacological treatments. The December issues of AGA's journals -- Clinical Gastroenterology and Hepatology and Gastroenterology -- highlight important updates into treatments for these two debilitating diseases. [More]
Research shows resveratrol in grapes inhibits bacteria that cause acne

Research shows resveratrol in grapes inhibits bacteria that cause acne

Got grapes? UCLA researchers have demonstrated how resveratrol, an antioxidant derived from grapes and found in wine, works to inhibit growth of the bacteria that causes acne. [More]
Deadly neurodegenerative disease treated in worms gives hope for humans

Deadly neurodegenerative disease treated in worms gives hope for humans

An untreatable and deadly neurodegenerative disease has been modelled and treated in worms by University of Liverpool researchers, suggesting a cure could be found for humans. [More]
Resveratrol supplements during pregnancy linked to developmental abnormalities in fetal pancreas

Resveratrol supplements during pregnancy linked to developmental abnormalities in fetal pancreas

New research in The FASEB Journal suggests that although resveratrol improved blood flow through the placenta of macaque monkeys and protected against harmful aspects of obesity, resveratrol injured the fetal pancreas. [More]
Study warns against use of resveratrol supplements by pregnant women

Study warns against use of resveratrol supplements by pregnant women

A widely available dietary supplement that had been considered safe - and that some claim provides anti-aging and other health benefits - caused significant developmental abnormalities in the pancreas of offspring of pregnant monkeys who were given the supplement, according to a study published today in the FASEB Journal, from the Federation of American Societies of Experimental Biology. [More]
People who consume diet rich in resveratrol are likely to develop cardiovascular disease

People who consume diet rich in resveratrol are likely to develop cardiovascular disease

A study of Italians who consume a diet rich in resveratrol — the compound found in red wine, dark chocolate and berries — finds they live no longer than and are just as likely to develop cardiovascular disease or cancer as those who eat or drink smaller amounts of the antioxidant. [More]
TSRI scientists identify molecular pathways that resveratrol uses to achieve beneficial action

TSRI scientists identify molecular pathways that resveratrol uses to achieve beneficial action

Resveratrol has been much in the news as the component of grapes and red wine associated with reducing “bad cholesterol,” heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism. [More]
Scientists reveal molecular secrets behind resveratrol's health benefits

Scientists reveal molecular secrets behind resveratrol's health benefits

Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism. [More]
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