Sarcoma News and Research

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Bioinformatics analysis of monkeypox virus-host cell interactions

A recent study posted to the bioRxiv* preprint server reported the interaction between monkeypox and human cells. Molecular sequences were screened to identify differentially expressed genes (DEGs) and their associated signal pathway, expression regulation, and metabolic pathways.

18 Oct 2022

Scientists develop an unprecedented animal model to investigate Ewing sarcoma

Ewing sarcoma is the second most frequent bone tumour in children, adolescents, and young adults. There is no specific treatment for this disease and current management is still limited to surgery, radiotherapy, and chemotherapy.

7 Oct 2022

Monkeypox virus infection in an immunocompromised patient

Researchers assessed the manifestations of the monkeypox infection in an immunocompromised patient.

19 Sep 2022

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

Study uncovers how air pollution can trigger lung cancer in individuals with no history of smoking

A new study revealed a link between air pollution and lung cancer in non-smokers.

13 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

12 Sep 2022

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Significant improvement in progression-free survival and response rate combined with reduced symptoms and better quality of life are reported as outcomes of a new treatment approach for patients with desmoid tumors, which are benign, but locally aggressive and invasive soft tissue tumors.

12 Sep 2022

New advice aims to reduce the cardiac side effects of cancer treatment

The first European Society of Cardiology Guideline on cardio-oncology is published online today in European Heart Journal.

26 Aug 2022

Soft-tissue sarcomas produce a protein that make immune cells 'go bad'

Investigators from Cedars-Sinai Cancer have discovered that cancerous tumors called soft-tissue sarcomas produce a protein that switches immune cells from tumor-attacking to tumor-promoting.

24 Aug 2022

Ian Frazer Centre for Children’s Immunotherapy Research aims to advance pediatric cancer care

Australia's first dedicated children's immunotherapy center will investigate treatments to not only increase the survival of kids with cancer, but to also improve their ongoing quality of life.

24 Aug 2022

Portable diagnostic device deployed in sub-Saharan Africa to identify cases of Kaposi sarcoma

A portable diagnostic device designed by researchers at Cornell Engineering and Weill Cornell Medicine has been deployed in clinical tests in Uganda to identify cases of Kaposi sarcoma, a common yet difficult-to-detect cancer that often signals the presence of HIV infection.

11 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

The Alliance for Clinical Trials in Oncology, in partnership with the National Cancer Institute, part of the National Institutes of Health, today announced the opening of a new study for participant enrollment that aims to obtain a reference set of blood samples from newly diagnosed patients with cancer and healthy individuals without cancer to include in a future study to assess the utility of early cancer detection blood tests.

1 Aug 2022

Best available chemotherapy for HIV-related Kaposi sarcoma would save lives and be cost-effective in Africa

Although antiretroviral therapy has markedly improved survival in people with AIDS-associated Kaposi sarcoma (a type of cancer caused by a virus), the condition is still a life-threatening problem in low- and middle-income countries.

15 Jul 2022

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Effective and safe treatments are needed for medulloblastoma-;the most common type of cancerous brain tumor in children-;especially for patients whose cancer has spread to the spinal cord.

14 Jul 2022

Sarcoma News and Research

Bioinformatics analysis of monkeypox virus-host cell interactions

Scientists develop an unprecedented animal model to investigate Ewing sarcoma

Monkeypox virus infection in an immunocompromised patient

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Study uncovers how air pollution can trigger lung cancer in individuals with no history of smoking

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

New advice aims to reduce the cardiac side effects of cancer treatment

Soft-tissue sarcomas produce a protein that make immune cells 'go bad'

Ian Frazer Centre for Children’s Immunotherapy Research aims to advance pediatric cancer care

Portable diagnostic device deployed in sub-Saharan Africa to identify cases of Kaposi sarcoma

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

Best available chemotherapy for HIV-related Kaposi sarcoma would save lives and be cost-effective in Africa

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Protein produced by soft-tissue sarcomas makes immune cells ‘go bad’

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

Scientists develop new way to attack synovial sarcoma using an investigational drug

Study: Nearly one-quarter of young sarcoma patients continue to use opioids after treatment completion

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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