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Reduced rheumatoid arthritis risk in schizophrenia linked to underreporting

People with a history of schizophrenia appear to have a lower risk of developing rheumatoid arthritis than the general population, but the association may be due to underreporting, say researchers. [More]

Further support for hippocampal volume as psychosis biomarker

Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia. [More]

Substance abuse worsens course of first-episode psychosis

Patients with first-episode psychosis who also present with substance abuse have a higher rate of hospitalisation after 12 months than their peers who do not, an Italian study reports. [More]

Factors predicting disengagement from psychosis early intervention identified

A study of first-episode psychosis patients in Hong Kong has found that those with fewer negative symptoms at presentation and poor medication compliance were more likely than others to disengage from an early intervention program. [More]
‘Healthy living’ programme fails to lower BMI in overweight psychosis patients

‘Healthy living’ programme fails to lower BMI in overweight psychosis patients

A “healthy living” intervention focused on exercise and diet has failed to impact body mass index in overweight people with psychosis when evaluated in the setting of a randomised controlled trial. [More]
Jazz Pharmaceuticals' Versacloz now commercially available in the U.S. for schizophrenia

Jazz Pharmaceuticals' Versacloz now commercially available in the U.S. for schizophrenia

Jazz Pharmaceuticals plc today announced U.S. commercial availability of Versacloz (clozapine, USP) oral suspension, the first and only oral suspension clozapine for severely ill treatment-resistant schizophrenia patients or those at risk of recurrent suicidal behavior with schizophrenia or schizoaffective disorder. [More]

Cognitive therapy promising for patients who shun antipsychotics

Cognitive behavioural therapy is a promising option for patients with schizophrenia who refuse to take antipsychotics, show the findings of a pilot randomised trial. [More]
Substance use ‘dramatically’ high in severe psychosis

Substance use ‘dramatically’ high in severe psychosis

Patients with severe psychotic disorders have a risk for smoking, heavy alcohol use, and other drug use that “far exceeds” that documented in patients with mild mental illness, shows a large study. [More]

People with severe mental illness may have higher risk for substance use

People with severe mental illness such as schizophrenia or bipolar disorder have a higher risk for substance use, especially cigarette smoking, and protective factors usually associated with lower rates of substance use do not exist in severe mental illness, according to a new study funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. [More]

Negative symptoms and cognition ‘relatively independent’ in schizophrenia

Diminished expression, a core negative symptom in people with schizophrenia, is significantly correlated with an array of cognitive functions, research by a Hong Kong team shows. [More]

Resting-state connectivity and metabolism dissociated in schizophrenia

A neuroimaging study suggests that patients with schizophrenia have difficulty deactivating the default mode network, rather than having increased absolute metabolic activity. [More]
Rates of smoking, drinking and drug use are higher among people with psychotic disorders

Rates of smoking, drinking and drug use are higher among people with psychotic disorders

In the largest ever assessment of substance use among people with severe psychiatric illness, researchers at Washington University School of Medicine in St. Louis and the University of Southern California have found that rates of smoking, drinking and drug use are significantly higher among those who have psychotic disorders than among those in the general population. [More]

Brain network disruption crosses psychosis diagnostic boundaries

Disruption of cortical information processing occurs in patients with psychosis regardless of whether they have a psychotic or affective diagnosis, research shows. [More]

Early natural history of bipolar disorder mapped

A longitudinal study of children of parents with bipolar disorder gives insights into the developmental trajectory of the condition, which researchers say should prove valuable in guiding future intervention and prevention efforts. [More]

Gray matter changes reflect psychosis burden

Changes in gray matter volume may be associated with psychosis burden rather than clinical diagnosis, research suggests. [More]
Novel approach confirms dysfunctional energy production in schizophrenia

Novel approach confirms dysfunctional energy production in schizophrenia

A method of directly assessing creatine kinase in the brain provides “direct and compelling” evidence for abnormal bioenergetics in the brains of patients with schizophrenia, say the study authors. [More]

Mood disorder subtypes remain in the family

Psychosis, mania, and depression are unlikely to have shared hereditary causes, report researchers in Molecular Psychiatry. [More]
Reviva announces successful completion of End-of-Phase 2 meeting for RP5063 drug

Reviva announces successful completion of End-of-Phase 2 meeting for RP5063 drug

Reviva Pharmaceuticals, Inc., a privately held pharmaceutical company focused on the discovery and development of new, safer and highly effective therapies for chronic indications, announced today the successful completion of an End-of-Phase 2 meeting with the Food and Drug Administration for its lead, new investigational antipsychotic drug, RP5063. [More]

Left-handers more likely to suffer from psychotic disorders

Researchers have long studied the connections between hand dominance and different aspects of the human brain. A new study out today in SAGE Open finds that among those with mental illnesses, left-handers are more likely to suffer from psychotic disorders such as schizophrenia than mood disorders. [More]

Psychosis prediction model could facilitate early intervention

A integrated model has shown “outstanding” ability to predict the transition to psychosis in clinically high-risk patients, report investigators in Schizophrenia Bulletin. [More]