Serotonin News and Research RSS Feed - Serotonin News and Research

Serotonin is one of several chemical messengers in the brain, or neurotransmitters, which help brain cells communicate with one another. Among many other functions, serotonin is involved in regulating mood. Problems with making or using the right amount of serotonin have been linked to many mental disorders, including depression, bipolar disorder, anxiety disorder, autism, and schizophrenia.

There are many genes that code for serotonin. Some of these genes guide serotonin production and other are involved in its activity. The serotonin transporter gene makes a protein that directs serotonin from the space between brain cells — where most neurotransmitters are relayed from one cell to another — back into cells, where it can be reused. Since the most widely prescribed class of medications for treating major depression acts by blocking this transporter protein, the gene has been a prime suspect in mood and anxiety disorders.

The serotonin transporter gene has many versions. Since everyone inherits a copy of this gene from each parent, a person may have two copies of the same version or one copy each of two different versions. One version of the serotonin transporter gene makes less protein, resulting in decreased transport of serotonin back into cells. This version has also long been the focus of depression research due to its suggested effect on risk.
Researchers identify control mechanism for mood disorders

Researchers identify control mechanism for mood disorders

Researchers at University of California, San Diego School of Medicine have identified a control mechanism for an area of the brain that processes sensory and emotive information that humans experience as "disappointment." [More]
People who take antidepressants are twice as likely to have dental implants fail

People who take antidepressants are twice as likely to have dental implants fail

A team from McGill University has discovered that people who take the most common antidepressants (such as Celexa, Paxil, Lexapro, Prozac, and Zoloft, the Selective Serotonin Reuptake Inhibitors or SSRIs) are twice as likely to have dental implants fail as those who are not taking SSRIs. [More]

Lower rates of suicide linked with more daily sunshine

Lower rates of suicide are associated with more daily sunshine in the prior 14 to 60 days. Light interacts with brain serotonin systems and possibly influences serotonin-related behaviors. Those behaviors, such as mood and impulsiveness, can play a role in suicide. [More]
Research to help patients suffering from severe spinal cord injuries

Research to help patients suffering from severe spinal cord injuries

Many patients suffer from severe spinal cord injuries after being involved in traffic accidents or accidents at work. [More]
Treatment with SSRIs linked with increased failure risk of osseointegrated implants

Treatment with SSRIs linked with increased failure risk of osseointegrated implants

The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "SSRIs and the Risk of Osseointegrated Implant Failure - A Cohort Study. [More]
New evidence puts into doubt the long-held depression belief

New evidence puts into doubt the long-held depression belief

New evidence puts into doubt the long-standing belief that a deficiency in serotonin - a chemical messenger in the brain - plays a central role in depression. In the journal ACS Chemical Neuroscience, scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been "depressed" by conventional wisdom) did not show depression-like symptoms. [More]
Huntingtin protein plays critical role in long-term memory development

Huntingtin protein plays critical role in long-term memory development

It has been more than 20 years since scientists discovered that mutations in the gene huntingtin cause the devastating progressive neurological condition Huntington's disease, which involves involuntary movements, emotional disturbance and cognitive impairment. [More]
Subtle changes in gene can predict how brain reacts to stress

Subtle changes in gene can predict how brain reacts to stress

Scientists studying depression in teens have discovered that subtle changes in a gene can predict how the brain reacts to stress, which can cause such health issues as depression, post-traumatic stress disorder and obesity. [More]
Epigenetic control of serotonin transporter predicts human brain function

Epigenetic control of serotonin transporter predicts human brain function

The tiny addition of a chemical mark atop a gene that is well known for its involvement in clinical depression and posttraumatic stress disorder can affect the way a person's brain responds to threats, according to a new study by Duke University researchers. [More]
Researchers uncover 3D structure of neuroreceptor

Researchers uncover 3D structure of neuroreceptor

Neurons are the cells of our brain, spinal cord, and overall nervous system. They form complex networks to communicate with each other through electrical signals that are carried by chemicals. [More]
Researchers find link between genetic makeup and nation's happiness

Researchers find link between genetic makeup and nation's happiness

Genetics could be the key to explaining nation's levels of happiness, according to research from the University of Warwick. [More]
Citalopram can increase efficacy of BMSCs differentiating into neuronal-like cells

Citalopram can increase efficacy of BMSCs differentiating into neuronal-like cells

There is evidence that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. [More]
Herbal supplement can become dangerous when taken with prescribed drugs

Herbal supplement can become dangerous when taken with prescribed drugs

St. John's wort, the leading complementary and alternative treatment for depression in the United States, can be dangerous when taken with many commonly prescribed drugs, according to a study by researchers at Wake Forest Baptist Medical Center. [More]
Researchers identify two classes of anti-depressants that reduce symptoms of depression

Researchers identify two classes of anti-depressants that reduce symptoms of depression

Depression is common in cancer, up to half of all patients facing the disease experience depressive symptoms, ranging from mild to severe. When depression co-exists with cancer, patients may be at an increased risk of death from cancer and from suicide. [More]
Researchers perform systematic review to identify best treatments for cancer-related depression

Researchers perform systematic review to identify best treatments for cancer-related depression

Depression is common in cancer, up to half of all patients facing the disease experience depressive symptoms, ranging from mild to severe. When depression co-exists with cancer, patients may be at an increased risk of death from cancer and from suicide. [More]
Forest Laboratories reports positive results from three Phase III trials of vilazodone for GAD treatment

Forest Laboratories reports positive results from three Phase III trials of vilazodone for GAD treatment

Forest Laboratories, Inc. today announced positive topline results from three Phase III trials evaluating the efficacy, safety and tolerability of vilazodone in adult patients with generalized anxiety disorder (GAD). [More]
Weizmann Institute scientists 'fingerprint' a culprit in depression and anxiety disorders

Weizmann Institute scientists 'fingerprint' a culprit in depression and anxiety disorders

According the World Health Organization, such mood disorders as depression affect some 10% of the world's population and are associated with a heavy burden of disease. That is why numerous scientists around the world have invested a great deal of effort in understanding these diseases. Yet the molecular and cellular mechanisms that underlie these problems are still only partly understood. [More]
Increase in protein helps store dopamine and protects from Parkinson's disease

Increase in protein helps store dopamine and protects from Parkinson's disease

Researchers from Emory's Rollins School of Public Health discovered that an increase in the protein that helps store dopamine, a critical brain chemical, led to enhanced dopamine neurotransmission and protection from a Parkinson's disease-related neurotoxin in mice. [More]
New path may lead to powerful adjunctive novel therapy for PTSD treatment

New path may lead to powerful adjunctive novel therapy for PTSD treatment

There are currently only two FDA-approved medications for the treatment of posttraumatic stress disorder (PTSD) in the United States. Both of these medications are serotonin uptake inhibitors. Despite the availability of these medications, many people diagnosed with PTSD remain symptomatic, highlighting the need for new medications for PTSD treatment. [More]
Alkermes initiates FORWARD-3 and FORWARD-4 efficacy studies in pivotal clinical program for ALKS 5461

Alkermes initiates FORWARD-3 and FORWARD-4 efficacy studies in pivotal clinical program for ALKS 5461

Alkermes plc today announced the initiation of FORWARD-3 and FORWARD-4, two of the three planned phase 3 core efficacy studies in the pivotal clinical program for ALKS 5461, a once-daily, oral investigational medicine with a novel mechanism of action for the adjunctive treatment of major depressive disorder (MDD). [More]