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Skin cancer is the most common type of cancer in the U.S. It occurs in more than a million people each year, including many older people. There are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and melanoma. Of the three, melanoma is the most serious. Skin cancer occurs when abnormal cells form and multiply in an uncontrolled way in the epidermis, or abnormal cells from the epidermis invade the dermis of the skin. Basal cell carcinoma, squamous cell carcinoma, and melanoma are skin cancers that are named for the epidermal cells from which they develop.
Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Oncologists combine two different types of immunotherapy to successfully treat metastatic melanoma

Oncologists at the Fred Hutchinson Cancer Research Center have successfully treated a patient with metastatic melanoma by combining two different types of immunotherapy. Cassian Yee and colleagues describe their approach in a paper, "Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient," that will be published online May 30 in The Journal of Experimental Medicine. [More]
Researchers develop new drugs for melanoma

Researchers develop new drugs for melanoma

Finding new, more effective and personalised treatments for cancer is the challenge of many researchers. A challenge that has been successfully met by a team from Inserm led by Stéphane Rocchi, which has just synthesised and developed new drugs for melanoma. [More]
Novel photonics device that listens to light can accurately detect skin cancer

Novel photonics device that listens to light can accurately detect skin cancer

Scientists are developing a new photonics device that listens to light and could be capable of detecting skin cancer and other diseases more accurately than ever before, eliminating the need for unnecessary and invasive biopsies. [More]
New paper-based sun-exposure sensor may help people stay safe

New paper-based sun-exposure sensor may help people stay safe

Summer is around the corner -- time for cookouts and sunbathing. But too much sun can result in sunburn, which is the main cause of skin cancer. Because the time it takes to get burned depends on many factors, it is not easy to tell when to seek shade. [More]
Malicious form of ATF2 protein drives formation of melanoma

Malicious form of ATF2 protein drives formation of melanoma

An international collaborative study led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a malicious form of a protein that drives the formation of melanoma. [More]
Radiation-immunotherapy combination can help treat melanoma

Radiation-immunotherapy combination can help treat melanoma

Combining radiation treatments with a new generation of immunotherapies is showing promise as a one-two-punch against melanoma, Loyola Medicine researchers report in a review article. [More]
Incorrect use of sunscreens could increase skin cancer risk

Incorrect use of sunscreens could increase skin cancer risk

How well do you understand sunscreen? For many consumers, the answer is not so well. According to new research, many people are still puzzled by the wide range of SPF numbers on product labels, and some may not be using sunscreen properly, which could increase their skin cancer risk. [More]
Lack of UV protection in car windows may contribute to increased cancer rates

Lack of UV protection in car windows may contribute to increased cancer rates

A recent analysis of the glass in car windows has shown that front windshields consistently provide a high level of ultraviolet (UV) protection whereas the UV protection afforded by side windows was much lower and more variable. Drivers who frequently make long journeys may thus be unwittingly exposing themselves to damaging UV rays. [More]
UV clothing can give better sunblock

UV clothing can give better sunblock

Just as most people know there is no such thing as safe smoking, there is also no such thing as safe sunbathing or tanning. Exposure to UVA and UVB rays can cause more than just a sunburn or tan - it can lead to everything from wrinkles to skin cancer. [More]
Report: Protecting eyes from UV exposure not high priority for Americans

Report: Protecting eyes from UV exposure not high priority for Americans

Three-quarters of Americans are concerned about potential eye problems from the sun's ultraviolet rays, yet only 31 percent protect their eyes with sunglasses or other UV-protective eyewear every time they go outside, according to a new nationwide survey released today. The report by The Vision Council, based on a survey of more than 10,000 adults, finds 34 percent of adults have experienced symptoms of prolonged UV exposure, such as eye irritation, trouble seeing, and red or swollen eyes. [More]
New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

In a step forward in the push for targeted treatments that can block the specific molecular malfunctions driving cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers have demonstrated how a genetic mutation can drive the most common type of lymphoma as well as melanoma, the deadliest form of skin cancer. [More]
Men need to brush up on their knowledge of skin cancer

Men need to brush up on their knowledge of skin cancer

Skin cancer can affect anyone, regardless of age, race or gender. When it comes to skin cancer prevention and detection, however, it seems that men need to brush up on their knowledge. [More]
Curve along edge of tumor may play major role in cancer cell metastasis

Curve along edge of tumor may play major role in cancer cell metastasis

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study. [More]
Low levels of vitamin D, methylation in black teens may increase cancer risk

Low levels of vitamin D, methylation in black teens may increase cancer risk

Low levels of vitamin D in black teens correlates with low activity of a major mechanism for controlling gene expression that may increase their risk of cancer and other disease, researchers report. [More]
Scientists aim to identify marker that could indicate aggressive basal cell skin cancer

Scientists aim to identify marker that could indicate aggressive basal cell skin cancer

Most basal cell skin cancers are easily removed -- those on the arm, leg or back. But when the cancer is on the eyelid or when it starts to invade surrounding tissue, it's no longer straightforward. [More]

EADV's Global Call to Action urges policy makers to protect Europe’s outdoor workers from UV-induced skin cancer

The European Academy of Dermatology and Venereology launched a Global Call to Action urging policy makers, employers, workers’ organisations and physicians to protect Europe’s outdoor workers from skin cancer caused by solar UV-radiation. [More]
PerkinElmer’s Phenoptics solution has potential to predict biomarker for anti-PD1 therapies for Merkel cell carcinoma

PerkinElmer’s Phenoptics solution has potential to predict biomarker for anti-PD1 therapies for Merkel cell carcinoma

PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, today announced that its Phenoptics™ quantitative pathology research system was an important component in skin cancer research published online in the April 19 edition of the New England Journal of Medicine. [More]
KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

A third of patients with advanced or metastatic melanoma will achieve an objective response to treatment with the programmed cell death protein inhibitor pembrolizumab, suggest KEYNOTE-001 findings, regardless of whether they have previously been treated with ipilimumab. [More]
Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy. [More]
Mouse model can help identify new, more effective melanoma-preventing agents

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD. [More]
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