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Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.
LIF-treated muscle stem cells show promise in treatment of muscular dystrophy

LIF-treated muscle stem cells show promise in treatment of muscular dystrophy

Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro. [More]
New study shows microRNAs play important role in inducing asthma

New study shows microRNAs play important role in inducing asthma

A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma. [More]
Scientists uncover how changes in metabolism of embryonic stem cells can help engineer new blood vessels

Scientists uncover how changes in metabolism of embryonic stem cells can help engineer new blood vessels

Researchers from the University of Illinois at Chicago College of Medicine have uncovered how changes in metabolism of human embryonic stem cells help coax them to mature into specific cell types — and may improve their function in engineered organs or tissues. [More]
Gamma-ray irradiation improves safety of stem cell transplantation in Parkinson’s disease patients

Gamma-ray irradiation improves safety of stem cell transplantation in Parkinson’s disease patients

Replacing dopamine-producing cells in the brain represents a promising therapeutic approach in Parkinson's disease, and a new study shows how post-transplantation gamma-ray irradiation can reduce the risk of tumor formation. [More]
Scientists discover how faulty genetic instructions contribute to development of AML

Scientists discover how faulty genetic instructions contribute to development of AML

Scientists have previously identified a series of genetic errors that commonly occur inside cancerous blood cells, but it hasn't been clear exactly how those genetic malfunctions create immature blood cells that overpopulate, crowd out healthy cells and spread in patients with acute myeloid leukemia or AML. [More]
Novel stem cell-containing bio-ink allows 3D printing of complex tissues for surgical implants

Novel stem cell-containing bio-ink allows 3D printing of complex tissues for surgical implants

Scientists at the University of Bristol have developed a new kind of bio-ink, which could eventually allow the production of complex tissues for surgical implants. [More]
Cells grown from pluripotent stem cells can pair with heart muscle cells to stimulate contractions

Cells grown from pluripotent stem cells can pair with heart muscle cells to stimulate contractions

Researchers at Johns Hopkins report that a type of lab-grown human nerve cells can partner with heart muscle cells to stimulate contractions. [More]
New studies provide future treatment strategies for stomach ulcers, IBD and alcoholic liver disease

New studies provide future treatment strategies for stomach ulcers, IBD and alcoholic liver disease

Basic and translational research paves the way for breakthroughs that can ultimately change patient care. [More]
Penn researchers help identify unique characteristics of reserve stem cells

Penn researchers help identify unique characteristics of reserve stem cells

Adult stem cells represent a sort of blank clay from which a myriad of different cell and tissue types are molded and as such are of critical importance to health, aging and disease. [More]
Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Adaptive Biotechnologies, the leader in combining next-generation sequencing (NGS) and expert bioinformatics to profile T- and B-cell receptors of the adaptive immune system, and collaborators will be presenting five studies demonstrating how Adaptive’s high-throughput sequencing platform enables diagnosis, detection and assessment of prognosis in hematological malignances and has increased sensitivity over flow cytometry. [More]
Complex 36-point therapeutic personalized program can help reverse memory loss in early AD patients

Complex 36-point therapeutic personalized program can help reverse memory loss in early AD patients

Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer's disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging. [More]
Salvage alloSCT remains option for progressing CML patients

Salvage alloSCT remains option for progressing CML patients

Research demonstrates the continuing role of allogeneic stem cell transplantation as a salvage option for patients with chronic myeloid leukaemia who progress to accelerated phase or blast crisis after tyrosine kinase inhibitor failure. [More]
Maintenance TKI therapy 'feasible' for high-risk CML patients after allogeneic HSCT

Maintenance TKI therapy 'feasible' for high-risk CML patients after allogeneic HSCT

Patients with high-risk chronic myeloid leukaemia who undergo allogeneic haematopoietic stem cell transplantation may benefit from continuing with tyrosine kinase inhibitor therapy, US clinicians believe. [More]
New technique may help replace brain cells, restore memory

New technique may help replace brain cells, restore memory

Although brains—even adult brains—are far more malleable than we used to think, they are eventually subject to age-related illnesses, like dementia, and loss of cognitive function. [More]
Scientists aim to heal failing heart with the body’s own cells

Scientists aim to heal failing heart with the body’s own cells

Babies born with heart defects live longer than ever thanks to advances in the diagnosis and treatment of congenital heart disease. Yet, despite substantial progress, many continue to face bleak odds, lifelong medication, multiple surgeries and progressive heart failure, often requiring a transplant. [More]
Autologous stem cell transplant safe, effective for HIV-associated lymphoma patients

Autologous stem cell transplant safe, effective for HIV-associated lymphoma patients

New research published online today in Blood Journal of the American Society of Hematology (ASH), challenges the generally held belief that individuals with HIV and aggressive lymphoma are not candidates for standard treatment. [More]
Prkci gene plays role in organizing cells during early embryo, organ formation

Prkci gene plays role in organizing cells during early embryo, organ formation

A gene called Prkci can point cells in the right direction, according to a new study in Developmental Biology. [More]
Study shows similarity between embryonic and reprogrammed stem cells

Study shows similarity between embryonic and reprogrammed stem cells

Stem cells are specialized undifferentiated cells that can divide and have the remarkable potential to develop into many different cell types in the body during early life and growth. [More]
New stem cell treatment may halt clinical relapses, development of new brain lesions in patients MS

New stem cell treatment may halt clinical relapses, development of new brain lesions in patients MS

A new use of chemotherapy followed by autologous haematopoietic stem cell transplantation (aHSCT) has fully halted clinical relapses and development of new brain lesions in 23 of 24 patients with multiple sclerosis (MS) for a prolonged period without the need for ongoing medication, according to a new phase 2 clinical trial, published in The Lancet. [More]
Inotuzumab ozogamicin study reveals complete remission rates higher than standard therapy for ALL patients

Inotuzumab ozogamicin study reveals complete remission rates higher than standard therapy for ALL patients

In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants. [More]
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