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A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from deterioration.
Nobel laureate-led study uses new technology to watch interaction between telomerase and telomeres

Nobel laureate-led study uses new technology to watch interaction between telomerase and telomeres

As the rope of a chromosomes replicates, it frays at the ends. No problem: A chromosome's ends have extra twine so that fraying doesn't reach into the body of the rope where the important information resides. [More]
Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure. [More]
Study reveals crucial role of TERRA in preservation of telomeres

Study reveals crucial role of TERRA in preservation of telomeres

Despite their especially compact structure that is difficult to access, telomeres transcribe information like the rest of the DNA. [More]
New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis. [More]
Male hormones can reverse biological drivers of aging, study shows

Male hormones can reverse biological drivers of aging, study shows

Telomerase, an enzyme naturally found in the human organism, is the closest of all known substances to a "cellular elixir of youth." In a recent study, Brazilian and US researchers show that sex hormones can stimulate production of this enzyme. [More]
Mutations in STN1 gene cause Coats plus syndrome

Mutations in STN1 gene cause Coats plus syndrome

A team of Israeli researchers has discovered that mutations in STN1, a gene that helps maintain the ends of chromosomes, cause the rare, inherited disorder Coats plus syndrome. [More]
Review highlights interconnected roles of apoptosis, cellular senescence in cancer and aging

Review highlights interconnected roles of apoptosis, cellular senescence in cancer and aging

A common feature of cancer and aging is cells' reduced ability to respond to stress-induced damage to DNA or cellular structures. [More]
Scientists discover new way to predict risk for delayed recovery in children with AML

Scientists discover new way to predict risk for delayed recovery in children with AML

The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission. [More]
Scientists develop new nonradioactive method to determine telomere length

Scientists develop new nonradioactive method to determine telomere length

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging. [More]
Maternal stress exposure can have major effect on child’s development and future health

Maternal stress exposure can have major effect on child’s development and future health

The environment the unborn child is exposed to inside the womb can have a major effect on her or his development and future health. Maternal stress during pregnancy can be transmitted biologically to the unborn child. [More]
Maintaining cardiomyocyte telomere length may enhance heart regeneration in adults

Maintaining cardiomyocyte telomere length may enhance heart regeneration in adults

Researchers at the Spanish National Center for Cardiovascular Research have discovered that the ends of heart muscle cell chromosomes rapidly erode after birth, limiting the cells' ability to proliferate and replace damaged heart tissue. [More]
TSRI study shows how specific gene mutation promotes growth of aggressive tumors

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors. [More]
First breakthrough in gene therapy against aging

First breakthrough in gene therapy against aging

In September 2015, then 44 year-old CEO of BioViva USA Inc. Elizabeth Parrish received two of her own company's experimental gene therapies: one to protect against loss of muscle mass with age, another to battle stem cell depletion responsible for diverse age-related diseases and infirmities. [More]
Person's age, mobility could be powerful predictors of survival than certain biomarkers

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Advances in technology allow scientists to measure intricate details about the human body that greatly enhance understanding of health, disease and aging. [More]
Scientists identify RingoA protein as key regulator of meiosis

Scientists identify RingoA protein as key regulator of meiosis

Published today in Nature Communications, a study by scientists at the Institute for Research in Biomedicine headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis--the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals. [More]
Shugoshin protein maintains proper gene expression in subtelomeres

Shugoshin protein maintains proper gene expression in subtelomeres

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation. [More]
New anti-ageing therapy may be effective against aplastic anaemia

New anti-ageing therapy may be effective against aplastic anaemia

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an important link with the ageing process: the shortening of telomeres, structures that protect the ends of chromosomes. [More]
Study provides detailed new information about diffuse glioma

Study provides detailed new information about diffuse glioma

An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes. [More]
Having more kids may lead to slower rate of aging

Having more kids may lead to slower rate of aging

A study by Simon Fraser University researchers suggests that the number of children born to a woman influences the rate at which her body ages. [More]
Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn't been clear. Now, Yale Cancer Center researchers have found an explanation in the tiny protective ends of chromosomes called telomeres. The findings will be presented Dec. 11 at the 2015 San Antonio Breast Cancer Symposium. [More]
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