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A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from deterioration.
TSRI study shows how specific gene mutation promotes growth of aggressive tumors

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors. [More]
First breakthrough in gene therapy against aging

First breakthrough in gene therapy against aging

In September 2015, then 44 year-old CEO of BioViva USA Inc. Elizabeth Parrish received two of her own company's experimental gene therapies: one to protect against loss of muscle mass with age, another to battle stem cell depletion responsible for diverse age-related diseases and infirmities. [More]
Person's age, mobility could be powerful predictors of survival than certain biomarkers

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Advances in technology allow scientists to measure intricate details about the human body that greatly enhance understanding of health, disease and aging. [More]
Scientists identify RingoA protein as key regulator of meiosis

Scientists identify RingoA protein as key regulator of meiosis

Published today in Nature Communications, a study by scientists at the Institute for Research in Biomedicine headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis--the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals. [More]
Shugoshin protein maintains proper gene expression in subtelomeres

Shugoshin protein maintains proper gene expression in subtelomeres

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation. [More]
New anti-ageing therapy may be effective against aplastic anaemia

New anti-ageing therapy may be effective against aplastic anaemia

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an important link with the ageing process: the shortening of telomeres, structures that protect the ends of chromosomes. [More]
Study provides detailed new information about diffuse glioma

Study provides detailed new information about diffuse glioma

An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes. [More]
Having more kids may lead to slower rate of aging

Having more kids may lead to slower rate of aging

A study by Simon Fraser University researchers suggests that the number of children born to a woman influences the rate at which her body ages. [More]
Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn't been clear. Now, Yale Cancer Center researchers have found an explanation in the tiny protective ends of chromosomes called telomeres. The findings will be presented Dec. 11 at the 2015 San Antonio Breast Cancer Symposium. [More]
UTMB researchers find mechanisms to determine when pregnant women go into labor

UTMB researchers find mechanisms to determine when pregnant women go into labor

During the last few weeks of a woman's pregnancy, many keep an overnight bag ready to go at a moment's notice in case they begin to go into labor. They do this because there is no clear signal that labor is about to begin - before the body makes it abundantly clear that this process has started. Understanding the mechanisms that initiate this process is especially important when treating women at risk of going into labor early. [More]
SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

A study conducted by the Spanish National Cancer Research Centre´s Genomic Instability Group, led by Óscar Fernández-Capetillo, describes for the first time in mammals, the role played by the SMC5/6 protein complex in cancer suppression and premature ageing. Mutations in these complexes, which were sensitive to chemotherapeutic agents, had been previously described in yeast cells, but their exact relationship with cancer or other diseases in mammals was unknown. [More]
ADHD children and their mothers more likely to have shorter telomeres, say Brazilian scientists

ADHD children and their mothers more likely to have shorter telomeres, say Brazilian scientists

Psychiatric disorders like Attention Deficit Hyperactive Disorder (ADHD) impact family's emotions and social life. It is well known. What is new is that this condition also affects the DNA of patients and their parents. [More]
Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

A few years ago, Javier Benítez, director of the Human Genetics Group at the CNIO, received a call from Pablo García Pavía, from the Cardiology Unit of the Puerta de Hierro University Hospital. This cardiologist was treating two brothers with a rare form of cancer, cardiac angiosarcoma (CAS). [More]
Molecular biology research holds promise in understanding cancer growth, aging

Molecular biology research holds promise in understanding cancer growth, aging

Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging. [More]
Alpha lipoic acid can stimulate telomerase with positive effects in mouse model of atherosclerosis

Alpha lipoic acid can stimulate telomerase with positive effects in mouse model of atherosclerosis

In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are both a sign of aging and contribute to it. Scientists at Emory University School of Medicine have found that the dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, the enzyme that lengthens telomeres, with positive effects in a mouse model of atherosclerosis. [More]
Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to ageing been confirmed; defective telomeres seem to be linked to more and more illnesses, including many types of cancer. [More]
Latent CMV infection induces telomere shortening

Latent CMV infection induces telomere shortening

The telomeres are repetitive DNA sequences at each end of our chromosomes. Studies show that in every cell division, the telomere is shortened. As a result, the telomere limits the cell to a fixed number of divisions and a limited life span. An essential part of human cells they affect how our cells age - as people with longer telomeres live longer lives. Surprisingly, people who are infected with a latent virus, that is, an asymptomatic virus, have shorter telomeres. [More]
Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

Hiroshima University researchers study promising biomarker for severity of ARWMCs, endothelial function

A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3'-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. [More]
Living in disadvantaged neighborhoods has direct impact on cellular health

Living in disadvantaged neighborhoods has direct impact on cellular health

Regardless of chronological age, people who live in neighborhoods with high crime, noise and vandalism are biologically more than a decade older than those who do not, according to a study led by researchers from the University of Pittsburgh. [More]
CNIO researchers identify new strategy to combat cancer

CNIO researchers identify new strategy to combat cancer

Scientists from the Spanish National Cancer Research Centre have discovered a new strategy to fight cancer, which is very different from those described to date. Their work shows for the first time that telomeres -- the structures protecting the ends of the chromosomes -- may represent an effective anti-cancer target: by blocking the TRF1 gene, which is essential for the telomeres, they have shown dramatic improvements in mice with lung cancer. [More]
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