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A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from deterioration.
TERT gene alterations co-occur with frequently altered bladder cancer genes

TERT gene alterations co-occur with frequently altered bladder cancer genes

In results presented today at the American Association for Cancer Research Annual Meeting 2015, a collaborative study by the University of Colorado Cancer Center and the National Cancer Institute reports that the TERT gene promoter was altered in 69 percent of 54 cases of bladder cancer due to variants that occur after birth (called "somatic") and in 56 percent of bladder cancers due to inherited variants (called "germline"). [More]
Johns Hopkins researchers find link between premature aging of telomere and lung diseases

Johns Hopkins researchers find link between premature aging of telomere and lung diseases

Lung diseases like emphysema and pulmonary fibrosis are common among people with malfunctioning telomeres, the “caps” or ends of chromosomes. Now, researchers from Johns Hopkins say they have discovered what goes wrong and why. [More]
Johns Hopkins researchers find link between premature aging of telomere and lung diseases

Johns Hopkins researchers find link between premature aging of telomere and lung diseases

Lung diseases like emphysema and pulmonary fibrosis are common among people with malfunctioning telomeres, the “caps” or ends of chromosomes. Now, researchers from Johns Hopkins say they have discovered what goes wrong and why. [More]
Findings may help doctors recommend appropriate treatments, improve patient outcomes

Findings may help doctors recommend appropriate treatments, improve patient outcomes

Like a car's front and back bumpers, your cell's chromosomes are capped by "telomeres" that protect this genetic material against deterioration. Still, after enough replications, a chromosome's telomeres break down and once they reach a certain point of degradation, the cell dies. This is one reason that cells are mortal: telomeres only last so long. That is, unless the enzyme telomerase builds new material onto the worn telomeres to reinforce these chromosomal "bumpers". Telomere repair can be a good thing, but in some cases it's not: overactive telomerase can lengthen telomeres until a cell becomes immortal…leading to cancer. [More]
Longer donor leukocyte telomere length linked to improved survival following HCT

Longer donor leukocyte telomere length linked to improved survival following HCT

Among patients with severe aplastic anemia who received stem cell transplant from an unrelated donor, longer leukocyte (white blood cells) telomere length (a structure at the end of a chromosome) was associated with increased overall survival at 5 years, according to a study in the February 10 issue of JAMA. [More]
DNA strands predict life expectancy

DNA strands predict life expectancy

BYU biologist Jonathan Alder has a startling secret he doesn't freely share: he knows when most of us are going to die. [More]
Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to researchers at NYU Langone Medical Center. [More]
Researchers develop new treatment that extends telomeres

Researchers develop new treatment that extends telomeres

Will extending telomeres lead to longer, healthier lives? Researchers have taken an important step toward answering this question by developing a new treatment used in the laboratory that extends telomeres. [More]
Childhood stress, psychiatric disorders linked to cellular changes that cause aging

Childhood stress, psychiatric disorders linked to cellular changes that cause aging

In a new study published online in Biological Psychiatry on January 16, 2015, researchers from Butler Hospital identify an association between biological changes on the cellular level and both childhood adversity and psychiatric disorders. [More]
TERT mutations may make smokers more susceptible to emphysema

TERT mutations may make smokers more susceptible to emphysema

Mutations in a gene that helps repair damaged chromosome ends may make smokers — especially female smokers — more susceptible to emphysema, according to results of a new study led by Johns Hopkins Kimmel Cancer Center researchers. [More]
UT Southwestern researchers target cells' biological clock to kill cancer cells, shrink tumor growth

UT Southwestern researchers target cells' biological clock to kill cancer cells, shrink tumor growth

Cell biologists at UT Southwestern Medical Center have targeted telomeres with a small molecule called 6-thiodG that takes advantage of the cell's 'biological clock' to kill cancer cells and shrink tumor growth. [More]
Researchers treat myocardial infarction with new telomerase-based gene therapy

Researchers treat myocardial infarction with new telomerase-based gene therapy

The enzyme telomerase repairs cell damage produced by ageing, and has been used successfully in therapies to lengthen the life of mice. Now it has been observed that it could also be used to cure illnesses related to the ageing process. [More]
Higher human exposure to metal cadmium can lead to shorter telomeres

Higher human exposure to metal cadmium can lead to shorter telomeres

A new study led by a researcher at Milken Institute School of Public Health at the George Washington University looks at the metal cadmium and finds that higher human exposure can lead to significantly shorter telomeres, bits of DNA at the ends of chromosomes that are associated with cardiovascular disease, diabetes and other diseases of old age. [More]
Study reveals impact of meditation, support groups at cellular level in breast cancer survivors

Study reveals impact of meditation, support groups at cellular level in breast cancer survivors

For the first time, researchers have shown that practising mindfulness meditation or being involved in a support group has a positive physical impact at the cellular level in breast cancer survivors. [More]
Innovative tool could redefine limits of synthetic biology, improve study of yeast genetics

Innovative tool could redefine limits of synthetic biology, improve study of yeast genetics

NYU Langone yeast geneticists report they have developed a novel tool -- dubbed "the telomerator" -- that could redefine the limits of synthetic biology and advance how successfully living things can be engineered or constructed in the laboratory based on an organism's genetic, chemical base-pair structure. [More]
Scientists identify gene mutation that causes aplastic anemia

Scientists identify gene mutation that causes aplastic anemia

An international team of scientists has identified a gene mutation that causes aplastic anemia, a serious blood disorder in which the bone marrow fails to produce normal amounts of blood cells. [More]
Longer telomeres increase melanoma risk

Longer telomeres increase melanoma risk

A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, an international research consortium, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma. [More]
Study uncovers new genetic risk factor for deadly skin cancer

Study uncovers new genetic risk factor for deadly skin cancer

Buffers that guard against damage to the ends of chromosomes could hold the key to a better understanding of malignant melanoma - the deadliest form of skin cancer - according to new research from the University of Leeds. [More]
DNA regions that contained telomeres generate RNAs

DNA regions that contained telomeres generate RNAs

RNA is one of the most primitive molecules associated with life that has awakened most interest over the last decade; a sister molecule to cellular DNA from which it originates via a process called transcription. [More]
Scientists solve key mystery in cancer research

Scientists solve key mystery in cancer research

A chance meeting between two leading UK and US scientists could have finally helped solve a key mystery in cancer research. [More]
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