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Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Bayer HealthCare and Onyx Pharmaceuticals Inc., an Amgen subsidiary, today announced that an investigational Phase 3 trial of NEXAVAR (sorafenib) tablets in patients with advanced breast cancer did not meet its primary endpoint of improving progression-free survival (PFS). [More]
Signs and symptoms of Lewy body dementia

Signs and symptoms of Lewy body dementia

"I watched my husband experience a decline in cognition followed by a period of what seemed like improved function only to plunge again into confusion with more frequent hallucinations," says one caregiver newly acquainted with Lewy body dementia (LBD). [More]
NeoGenomics launches 23 NGS-based NeoTYPE Cancer Profiles

NeoGenomics launches 23 NGS-based NeoTYPE Cancer Profiles

NeoGenomics, Inc., a leading provider of cancer-focused genetic and molecular testing services, announced today it has launched 23 new and innovative NeoTYPE Cancer Profiles based on next-generation sequencing (NGS). [More]
Study on cancer care offers model for possible lower spending on treatment

Study on cancer care offers model for possible lower spending on treatment

The study, however, raised some questions because while it cut costs by a third and showed no decline in patient health, the spending on chemotherapy medications rose. [More]
Thyroid hormone protects cholinergic neurons in hippocampus of naturally aged mice

Thyroid hormone protects cholinergic neurons in hippocampus of naturally aged mice

Can thyroid hormone protect neuronal function and increase the survival rate of naturally aged animals? Prof. Ailing Fu and her team, School of Pharmaceutical Sciences, Southwest University, China performed an animal experiment in which aged mice were administered with low dose of levothyroxine for 3 consecutive months. [More]
Bayer announces Health Canada approval of Nexavar for differentiated thyroid cancer treatment

Bayer announces Health Canada approval of Nexavar for differentiated thyroid cancer treatment

Bayer Inc. is pleased to announce the Health Canada approval of Nexavar for the treatment of patients with locally advanced or metastatic, progressive, differentiated thyroid carcinoma (DTC), refractory to radioactive iodine (RAI). [More]
Researchers develop new "nanojuice" to help doctors better identify human gut

Researchers develop new "nanojuice" to help doctors better identify human gut

Located deep in the human gut, the small intestine is not easy to examine. X-rays, MRIs and ultrasound images provide snapshots but each suffers limitations. Help is on the way. [More]
Thyroxine may overcome mutated thyroid hormone receptor effects

Thyroxine may overcome mutated thyroid hormone receptor effects

Patients with a mutation in the thyroid hormone receptor α gene that affects both the thyroid hormone receptor α1 and α2 protein variants have similar characteristics to patients with mutations affecting only the α1 variant, report researchers. [More]
Highmark, Horizon issued positive coverage policies for Afirma Gene Expression Classifier

Highmark, Horizon issued positive coverage policies for Afirma Gene Expression Classifier

Veracyte, Inc., a molecular diagnostics company pioneering the field of molecular cytology, today announced that two Blue Cross Blue Shield–affiliated organizations, Highmark Inc. and Horizon Blue Cross Blue Shield of New Jersey, have issued positive coverage policies for the company's Afirma Gene Expression Classifier (GEC). [More]
ANMAT approves Genzyme’s Lemtrada for treatment of relapsing remitting multiple sclerosis

ANMAT approves Genzyme’s Lemtrada for treatment of relapsing remitting multiple sclerosis

Genzyme, a Sanofi company (EURONEXT:SAN and NYSE:SNY), announced today that Argentina's National Administration of Drugs, Food and Medical Technology (ANMAT) has approved LemtradaTM (alemtuzumab) for adult patients with relapsing remitting multiple sclerosis (RRMS) with active disease defined by clinical or imaging features. [More]
Weak hospice oversight makes safety problems hard to identify

Weak hospice oversight makes safety problems hard to identify

The typical hospice undergoes a full government inspection about once every six years, according to The Washington Post, making it one of the least scrutinized areas of U.S. health care. [More]
Administering low doses of thyroid hormone to rats with diabetes prevents deterioration of heart function

Administering low doses of thyroid hormone to rats with diabetes prevents deterioration of heart function

Administering low doses of a thyroid hormone to rats with diabetes helps restore hormone levels in their hearts and prevented deterioration of heart function and pathology, according to a new study by NYIT College of Osteopathic Medicine Professor and Biomedical Sciences Chair A. Martin Gerdes. [More]
Guide to treating endocrine and metabolic emergencies released at ICE/ENDO 2014

Guide to treating endocrine and metabolic emergencies released at ICE/ENDO 2014

The Endocrine Society's publishing imprint Endocrine Press released its first original title, Endocrine and Metabolic Medical Emergencies, today during the Society's annual meeting, ICE/ENDO 2014. [More]
People with significant hypothyroidism can experience impaired driving

People with significant hypothyroidism can experience impaired driving

People with significant hypothyroidism can experience impaired driving similar to those who are driving when intoxicated by alcohol, a new study finds. [More]
Experts from 96 countries gather in Chicago to attend ICE/ENDO 2014

Experts from 96 countries gather in Chicago to attend ICE/ENDO 2014

ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society, has tallied more registrants than any other annual meeting in the Endocrine Society's nearly 100-year history. [More]
Research provides unique insight into lncRNAs that regulate lung development

Research provides unique insight into lncRNAs that regulate lung development

It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins. [More]
Apitope starts preclinical development of ATX-GD-459 for Graves' disease treatment

Apitope starts preclinical development of ATX-GD-459 for Graves' disease treatment

Apitope, the drug discovery and development company focused on disease-modifying treatments for patients with autoimmune and allergic diseases, announced today that it has started preclinical development of its novel peptide therapy ATX-GD-459 for the treatment of Graves' disease. [More]
GENETICS and G3: Genes|Genomes|Genetics publish special collection on genetics of immunity

GENETICS and G3: Genes|Genomes|Genetics publish special collection on genetics of immunity

Immunity is what stops you dying from a common cold or a tiny pinprick. Differences in resistance or tolerance to disease influence who catches the bug that's going around the office, or which species succumb to the deadly fungus devastating frogs around the world. [More]
Affordable Care Act to have significant impact on patients with diabetes

Affordable Care Act to have significant impact on patients with diabetes

The Affordable Care Act (ACA, also known as Obamacare) is dramatically changing health care delivery in the U.S. Specific parts of the new law, which will be phased in through 2020, will have a significant impact on patients with diabetes and prediabetes, as explored in a comprehensive Review article published in Diabetes Technology & Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
Researchers examine role of female sex hormones in male obesity

Researchers examine role of female sex hormones in male obesity

An imbalance of female sex hormones among men in Western nations may be contributing to high levels of male obesity, according to new research from the University of Adelaide. [More]