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What is the association between prenatal opioid exposure and risk of immune-related conditions?

Researchers compared the risk of hospitalization and emergency department presentation for immune-related conditions in children with and without prenatal opioid exposure.

19 Jan 2024

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Cannabidiol (CBD) is marketed by some suppliers as a painkiller, e.g. for osteoarthritis of the knee. Animal experiments have shown that the substance, which is extracted from the hemp plant, has an anti-inflammatory and pain-relieving effect in arthritis.

14 Nov 2023

One health wake-up call: London's river data highlights environmental perils

The largest-ever spatiotemporal monitoring of chemicals/contaminants of emerging concern (CECs) in London waterways.

26 Sep 2023

New guideline supports use of acetaminophen and NSAIDs for pediatric dental pain

Acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are recommended as first-line treatments for managing short-term dental pain in children under age 12, according to a new clinical practice guideline developed by the American Dental Association Science & Research Institute (ADASRI), the University of Pittsburgh School of Dental Medicine and the Center for Integrative Global Oral Health at the University of Pennsylvania School of Dental Medicine.

25 Aug 2023

Understanding factors associated with long-term opioid use in fibromyalgia patients

Fibromyalgia is common, affecting around 2% of people in the general population. The 2017 EULAR recommendations state that tramadol - a weak opioid - may be considered for pain management in fibromyalgia, but advise against use of strong opioids due to lack of evidence of efficacy, and the high risk of side effects and addiction.

2 Jun 2023

Study finds lack of high certainty evidence on the efficacy and safety of analgesics for low back pain

Despite nearly 60 years of research, there is still a lack of high certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence published by The BMJ.

23 Mar 2023

New approach to pain management can reduce opioid use after urethroplasty

For men undergoing surgery to repair scarring in the urethra (urethroplasty), a new approach to pain management can reduce the need for strong opioid drugs without compromising pain control, reports a study in Urology Practice, an Official Journal of the American Urological Association.

21 Feb 2023

NY docs are now required to prescribe naloxone to some patients on opioid painkillers

Without opioid painkillers to dull the ache in his knees and other joints, Arnold Wilson wouldn't be able to walk half a block. The 63-year-old former New York City nurse has crippling arthritis for which he takes OxyContin twice a day and oxycodone when he needs additional relief.

5 Jan 2023

New long-term opioid use associated with a heightened risk of death, study finds

New long term use of opioids to quell pain after lung cancer surgery is linked to a 40% heightened risk of death from any cause within the next 2 years, finds research published online in the journal Regional Anesthesia & Pain Medicine.

13 Sep 2022

Review of ERAS programs in minimally invasive gynecologic surgery shows improved patient outcomes

Following Enhanced Recovery After Surgery (ERAS) protocols designed to minimize surgical stress results in improved patient recovery and satisfaction, reduced postoperative complications, and shorter hospital stays, according to a review of ERAS programs in minimally invasive gynecologic surgery by UT Southwestern researchers.

29 Aug 2022

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and kidney function, comorbid medical problems and polypharmacy (the simultaneous use of multiple drugs to treat medical conditions).

28 Jun 2022

Study shows a small increased risk of congenital abnormalities in infants exposed to opioids in utero

A new study in CMAJ shows a small increased risk of congenital abnormalities in infants exposed to opioid medications in the first trimester of pregnancy.

7 Feb 2022

Persistent opioid use among 12% of patients after cardiac implantable electronic device procedures

About 12 percent of patients who receive implantable cardiac devices such as a pacemaker or defibrillator and fill an opioid prescription after surgery will consistently use the pain medication in the months afterward, raising the potential for addiction following these common procedures and identifying another pathway that could contribute to the national opioid crisis, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

26 Nov 2021

Children and young adults are frequently exposed to unsafe opioid prescriptions, study suggests

Children and young adults who have pain from surgery, dental care and other conditions are often prescribed opioids.

19 Aug 2021

New pain management regimen reduced opioid exposure in trauma patients

A pain management regimen comprised mostly of over-the-counter medication reduced opioid exposure in trauma patients while achieving equal levels of pain control, according to a new study by physician-researchers at The University of Texas Health Science Center at Houston (UTHealth).

22 Jan 2021

Multimodal pain regimen minimizes opioid exposure, relieves acute pain in trauma patients

A multimodal pain regimen (MMPR) designed to minimize opioid exposure and relieve acute pain associated with traumatic injury kept patient self-reported pain scores low while also reducing the daily and total amount of opioid drugs given to trauma patients.

21 Jan 2021

Genetic analysis reveals novel traits associated with COVID-19 severity

Researchers in the United States have conducted genetic correlation studies revealing novel traits associated with the development of severe coronavirus disease 2019 (COVID-19).

23 Dec 2020

Despite new CDC guidance, opioid prescription rates have not declined

Research from Saint Louis University finds that among patients at risk for opioid misuse, the odds of receiving a schedule II opioid for non-cancer pain were similar to those not at risk, despite new prescribing guidelines from the Centers for Disease Control (CDC).

2 Dec 2020

Oral methotrexate can be an effective intervention for people with knee OA

A new study presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that after three months of treatment with oral methotrexate, adults with primary knee osteoarthritis (OA) with inflammation had significant improvements in physical function and inflammation, a sign that this inexpensive, generic pill may be an important intervention for knee OA.

6 Nov 2020

FDA issues warning letters to website operators for illegally selling opioids online

The U.S. Food and Drug Administration has issued warning letters to 17 website operators for illegally selling unapproved and misbranded opioids online in violation of the Federal Food, Drug, and Cosmetic Act.

10 Sep 2020