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Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

New review: 1.6% of women and girls have debilitating Premenstrual Dysphoric Disorder

Around 1.6% of women and girls have symptomatic Premenstrual Dysphoric Disorder (PMDD), according to a new review of global studies.

7 Feb 2024

Immune cell networks key to success of personalized cancer treatment

Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are likely to respond to a personalized immunotherapy known as adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL).

7 Feb 2024

First gene therapy trial aims to restore hearing in children

The aim of this clinical trial, which has just received approval in France, is to assess the safety and efficacy of a new gene therapy drug in children aged between 6 and 31 months with profound hearing loss.

5 Feb 2024

New points-to-consider in the diagnosis, treatment of systemic hyperinflammatory syndromes

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes.

5 Feb 2024

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) -; soft tissue tumors that are stubbornly resistant to chemotherapy and radiation -; according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.

31 Jan 2024

Scientists regenerate fully functional urinary bladder tissue using a non-human primate model

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University succeeded in regenerating fully functional urinary bladder tissue in a long-term study utilizing a non-human primate model.

30 Jan 2024

Understanding the interplay between gut microbiota and vascular dysfunction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Vascular diseases, including atherosclerosis, aneurysms, and vascular calcification, are a leading cause of morbidity and mortality worldwide.

30 Jan 2024

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

NewsMedical speaks with Chao Ma, Ph.D. a Research Assistant Professor at New York University Tandon School of Engineering, ahead of his presentation at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 29 Jan 2024

Research upends understanding of circadian clock in melanoma

A Ludwig Cancer Research study has found that the circadian clock-;which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive-;in fact has a contextually variable role in cancer.

27 Jan 2024

Low-dose radiation shows promise as treatment for brain injury and stroke

Traumatic brain injury (TBI) and ischemic stroke are major public health concerns and leading causes of death and disability worldwide.

27 Jan 2024

Unbiased assessment of vamorolone for treating Duchenne muscular dystrophy

The drug vamorolone (Agamree) has been hailed as a promising new drug to treat Duchenne muscular dystrophy (DMD).

25 Jan 2024

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Researchers analyzed the toxicity concerns and advancements in mRNA therapeutics, focusing on their cellular toxicity, reactogenicity, and distribution, and discussed the challenges and benefits of mRNA research.

24 Jan 2024

Specialist support helps new moms with severe mental illness reduce relapse risk

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London, and in partnership with the University of Exeter and the London School of Hygiene & Tropical Medicine, has found that women with a history of severe mental illness face a lower risk of relapse after giving birth in regions where they have access to a community perinatal mental health team (CPMHT).

23 Jan 2024

3D-printed liver model paves way for new MASH treatments

Metabolic dysfunction- associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by the condition, and roughly 24% of adults having nonalcoholic fatty liver disease (NAFLD).

23 Jan 2024

New study reveals effective strategies against drug resistance in hospital-acquired pneumonia treatment

A novel rabbit infection model to investigate meropenem's resistance development.

23 Jan 2024

Scientists discover a possible therapeutic target for pulmonary hypertension

A team led by Dr. Guadalupe Sabio at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid has discovered a possible therapeutic target for pulmonary hypertension.

22 Jan 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

What makes people gag at dentists?

Study finds a significant correlation between self-reported emetophobia, excessive gagging, and dental anxiety, with over 50% of participants recalling unpleasant vomiting or gagging experiences and a notable impact of dental office smells on these conditions.

17 Jan 2024

AMIE AI system outshines doctors in simulated medical consultations

The AMIE AI system outperforms primary care physicians in diagnostic accuracy and conversation quality in simulated medical consultations.

16 Jan 2024

Translation News and Research

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

New review: 1.6% of women and girls have debilitating Premenstrual Dysphoric Disorder

Immune cell networks key to success of personalized cancer treatment

First gene therapy trial aims to restore hearing in children

New points-to-consider in the diagnosis, treatment of systemic hyperinflammatory syndromes

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

Scientists regenerate fully functional urinary bladder tissue using a non-human primate model

Understanding the interplay between gut microbiota and vascular dysfunction

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

Research upends understanding of circadian clock in melanoma

Low-dose radiation shows promise as treatment for brain injury and stroke

Unbiased assessment of vamorolone for treating Duchenne muscular dystrophy

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Specialist support helps new moms with severe mental illness reduce relapse risk

3D-printed liver model paves way for new MASH treatments

New study reveals effective strategies against drug resistance in hospital-acquired pneumonia treatment

Scientists discover a possible therapeutic target for pulmonary hypertension

Ludwig scientists deconstruct the blood supply of brain metastases

What makes people gag at dentists?

AMIE AI system outshines doctors in simulated medical consultations

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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