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Ovarian tissue freezing offers hope for extended fertility

Most women agree that menopause has its advantages and disadvantages. Some relish the end of menstruation and concerns about unplanned pregnancies, while others dread the possibililty of hot flashes, moodiness, and other unpleasant symptoms.

6 Feb 2024

NIH awards $1.9 million to investigate how complex communities of microbes impact human health

The bacteria and microorganisms that live within the human body -; the microbiota -; can impact human health, disease risk and even how the body absorbs medications, but the details of these processes are unclear.

5 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

$Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery$

Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery

A large multicenter clinical trial co-led by University of Maryland School of Medicine researchers large multicenter clinical trial co-led by University of Maryland School of Medicine researchers found that an antiseptic containing iodine resulted in about one-quarter fewer post-surgical infections in patients with limb fractures compared to another frequently used skin antiseptic.

2 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Machine learning could personalize diuretic treatment for patients with acute decompensated heart failure

A recent study co-authored by Dr. Matthew Segar, a third-year cardiovascular disease fellow at The Texas Heart Institute and led by his research and residency mentor, University of Texas Southwestern Medical Center's Dr. Ambarish Pandey, utilized a machine learning-based approach to identify, understand, and predict diuretic responsiveness in patients with acute decompensated heart failure (ADHF).

31 Jan 2024

Gene therapy could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy

A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.

30 Jan 2024

Study offers insights into who's at risk for long COVID among immunocompromised patients

Early in the pandemic, clinicians noticed that certain immunocompromised patients were experiencing persistent SARS-CoV-2 infections, some lasting weeks to months at a time.

26 Jan 2024

Study establishes the ideal immunosuppression regimen for pig-to-human kidney xenotransplantation

Currently used Food and Drug Administration-approved transplant drugs -; with the addition of an also already FDA-approved complement inhibitor -; are the optimal immunosuppression regimen for pig-to-human kidney transplants, according to a landmark discovery by University of Alabama at Birmingham investigators.

25 Jan 2024

Penn analysis shows low risk of secondary cancers following CAR T cell therapy

The development of any type of second cancer following CAR T cell therapy is a rare occurrence, as found in an analysis of more than 400 patients treated at Penn Medicine, researchers from the Perelman School of Medicine at the University of Pennsylvania reported today in Nature Medicine.

24 Jan 2024

Mayo Clinic unveils "secret gene" key to reversing heart failure in some patients

Mayo Clinic researchers studying the genetics of people who had recently developed dilated cardiomyopathy, one of the most common causes of heart failure, have found a particular gene to target for developing future drug therapy treatments.

24 Jan 2024

Bladder and gut fermentation syndromes: Uncommon disorders with significant implications

Study reviews bladder fermentation syndrome (BFS) and gut fermentation syndrome (GFS), highlighting their etiology, diagnosis, and treatment, and emphasizing the importance of recognizing these conditions to avoid misinterpretation in abstinence monitoring.

23 Jan 2024

3D-printed liver model paves way for new MASH treatments

Metabolic dysfunction- associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by the condition, and roughly 24% of adults having nonalcoholic fatty liver disease (NAFLD).

23 Jan 2024

Study provides valuable insights into the evolutionary dynamics of hepatitis E virus

A combination therapy with multiple drugs is more effective than just one active compound. To begin with, at least.

23 Jan 2024

NIH grant funds the development of allograft-rejection-on-a-chip model

Vadim Jucaud, Ph.D., Assistant Professor at the Terasaki Institute for Biomedical Innovation, has been awarded a grant from the National Institutes of Health to develop a functional organ-on-a-chip to model allogeneic transplant rejection.

23 Jan 2024

Cancer drug holds promise for shrinking polycystic kidney cysts

Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function.

22 Jan 2024

Women and minorities bear the brunt of medical misdiagnosis

Charity Watkins sensed something was deeply wrong when she experienced exhaustion after her daughter was born.

18 Jan 2024

Decoding blood cancer secrets to optimize CAR T therapy

Chimeric antigen receptor T-cell therapy, or CAR T, has dramatically improved the treatment of certain blood cancers. Initially approved for patients who had failed multiple lines of therapy, clinical trials have shown CAR T can be used as an earlier treatment option.

17 Jan 2024

Scotland's NHS Golden Jubilee heart transplant unit expands to support more patients

Scotland’s only heart transplant centre at NHS Golden Jubilee, is expanding to support more patients across Scotland than ever before.

13 Jan 2024

Drug-resistant Candida: Study uncovers evolutionary tricks of a fungal pathogen

Global fungal infections, which affect one billion people and cause 1.5 million deaths each year, are on the rise due to the increasing number of medical treatments that heighten vulnerability.

12 Jan 2024

Transplant News and Research

Ovarian tissue freezing offers hope for extended fertility

NIH awards $1.9 million to investigate how complex communities of microbes impact human health

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Large trial finds iodine-based antiseptic to be more effective for closed fracture surgery

CRISPR revolutionized: New method edits genes directly in the body

Machine learning could personalize diuretic treatment for patients with acute decompensated heart failure

Gene therapy could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy

Study offers insights into who's at risk for long COVID among immunocompromised patients

Study establishes the ideal immunosuppression regimen for pig-to-human kidney xenotransplantation

Penn analysis shows low risk of secondary cancers following CAR T cell therapy

Mayo Clinic unveils "secret gene" key to reversing heart failure in some patients

Bladder and gut fermentation syndromes: Uncommon disorders with significant implications

3D-printed liver model paves way for new MASH treatments

Study provides valuable insights into the evolutionary dynamics of hepatitis E virus

NIH grant funds the development of allograft-rejection-on-a-chip model

Cancer drug holds promise for shrinking polycystic kidney cysts

Women and minorities bear the brunt of medical misdiagnosis

Decoding blood cancer secrets to optimize CAR T therapy

Scotland's NHS Golden Jubilee heart transplant unit expands to support more patients

Drug-resistant Candida: Study uncovers evolutionary tricks of a fungal pathogen

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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