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Tropical diseases encompass all diseases that occur solely, or principally, in the tropics. In practice, the term is often taken to refer to infectious diseases that thrive in hot, humid conditions, such as malaria, leishmaniasis, schistosomiasis, onchocerciasis, lymphatic filariasis, Chagas disease, African trypanosomiasis, and dengue.
Improving innovation uptake in the NHS

Improving innovation uptake in the NHS

I think innovation is one of those rather slippery terms that means different things to different people. First of all, I would make a distinction between innovations that are essentially about a new, physical product and innovations that are more to do with services or processes. [More]
New approach bolsters protein in blood vessels to protect against cerebral malaria

New approach bolsters protein in blood vessels to protect against cerebral malaria

Boosting a protective protein to stabilize blood vessels weakened by malaria showed improved survival beyond that of antimalarial drugs alone in pre-clinical research. [More]
Researchers working to find faster way to treat sleeping sickness using oral drugs

Researchers working to find faster way to treat sleeping sickness using oral drugs

Researchers at the University of Georgia are working to find the fastest way possible to treat and cure human African trypanosomiasis, long referred to as sleeping sickness. By working to improve chemical entities already tested in human clinical trials, they hope to have a faster route to field studies to treat the disease using drugs that can be administered orally to patients. [More]
Scientists discover novel African types of Salmonella linked to blood poisoning and death

Scientists discover novel African types of Salmonella linked to blood poisoning and death

The first global-scale genetic study of Salmonella Enteritidis bacteria, which is a major cause of blood poisoning and death in Africa and food poisoning in the Western World, has discovered that there are in fact three separate types. [More]
People with lymphatic filariasis more likely to acquire HIV infection, study shows

People with lymphatic filariasis more likely to acquire HIV infection, study shows

People infected with a parasitic worm called Wuchereria bancrofti in areas where HIV is endemic may be more likely to acquire HIV than people who are not infected with the worm, according to a new study in southwest Tanzania, published in The Lancet. [More]
Scientists reveal new transmission path for yaws

Scientists reveal new transmission path for yaws

Lesions on arms and legs, deformed faces - yaws is a tropical disease that infects the skin, bones and cartilage. It is caused by the bacterium Treponema pallidum subspecies pertenue [More]
Griffith researchers create Malaria Box to advance drug discovery for major topical diseases

Griffith researchers create Malaria Box to advance drug discovery for major topical diseases

Griffith University tropical disease researchers have joined together with a host of international laboratories to advance drug discovery for major topical diseases through the creation and testing of the Malaria Box. [More]
Researchers uncover novel virulence strategies employed by Leishmania parasite

Researchers uncover novel virulence strategies employed by Leishmania parasite

Professor Albert Descoteaux of INRS-Institut Armand-Frappier Research Centre and his team have discovered novel virulence strategies employed by the Leishmania parasite. [More]
Researchers identify mechanisms triggering hypergammaglobulinemia

Researchers identify mechanisms triggering hypergammaglobulinemia

Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this hypergammaglobulinemia? A team headed by INRS's Professor Simona Stäger has successfully identified the mechanisms triggering the phenomenon. [More]
New and inexpensive technique could help meet global demands for malaria drug

New and inexpensive technique could help meet global demands for malaria drug

A new and inexpensive technique for mass-producing the main ingredient in the most effective treatment for malaria, artemisinin, could help meet global demands for the drug, according to a study to be published in the journal eLife. [More]
FDA approves Vaxchora for prevention of cholera

FDA approves Vaxchora for prevention of cholera

The U.S. Food and Drug Administration today approved Vaxchora, a vaccine for the prevention of cholera caused by serogroup O1 in adults 18 through 64 years of age traveling to cholera-affected areas. Vaxchora is the only FDA-approved vaccine for the prevention of cholera. [More]
Guardian system can predict risk of dangerous diseases

Guardian system can predict risk of dangerous diseases

If an infectious disease outbreak or an attack using an agent such as anthrax were to occur in Chicago, it most likely first will be noticed in emergency rooms throughout the city. Swift identification of the cause of an incoming patients' illness could be crucial to public health and safety personnel being able to intervene in time to save lives. [More]
Addition of just two DNA bases to LdAQP1 gene helps Black Fever parasite to overcome antimonial drugs

Addition of just two DNA bases to LdAQP1 gene helps Black Fever parasite to overcome antimonial drugs

Wellcome Trust Sanger Institute scientists show how the parasite responsible for the neglected tropical disease Black Fever (visceral leishmaniasis) can become resistant to drug treatment. Studying the whole genomes of more than 200 samples of Leishmania donovani revealed that the addition of just two bases of DNA to a gene known as LdAQP1 stops the parasite from absorbing antimonial drugs. [More]
Genome sequencing shows association between STIs and Trachoma

Genome sequencing shows association between STIs and Trachoma

For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world's leading infectious cause of blindness, according to a study in Nature Communications. [More]
Researchers take major step towards developing vaccine for river blindness

Researchers take major step towards developing vaccine for river blindness

The world's first vaccine for a disease that causes misery for millions in Africa could be tested within five years. [More]
UCSD Skaggs School of Pharmacy, Janssen R&D partner to identify new therapeutic targets for Chagas disease

UCSD Skaggs School of Pharmacy, Janssen R&D partner to identify new therapeutic targets for Chagas disease

Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego have entered into a research collaboration with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to identify new therapeutic targets for Chagas disease, a parasitic infection that is the leading cause of heart failure in Latin America. [More]
Treating multidrug-resistant tuberculosis with regimens may improve outcomes

Treating multidrug-resistant tuberculosis with regimens may improve outcomes

Treating multidrug-resistant tuberculosis (MDR TB) with regimens that include a greater number of drugs may improve outcomes, and baseline drug susceptibility testing (DST) could identify drugs with the greatest likelihood of success, according to a paper published this week in PLOS Medicine. [More]
More effort needed to reduce risks of mosquito-transmitted epidemics in the U.S. and Mexico

More effort needed to reduce risks of mosquito-transmitted epidemics in the U.S. and Mexico

Despite the increasing risks of mosquito-transmitted epidemics in the United States and Mexico, policymakers in both countries have made little effort to prevent future outbreaks, according to a new policy brief by tropical-disease and science policy experts at Rice University's Baker Institute for Public Policy. [More]
Risk of developing visceral leishmaniasis much higher in transplant patients

Risk of developing visceral leishmaniasis much higher in transplant patients

Researchers from Spain have analysed the prevalence of leishmaniasis among the population of organ transplant recipients. The findings of this study, published in the journal 'PLoS Neglected Tropical Disease', confirm that the risk of developing visceral leishmaniasis ‑the most severe form of the disease which can pose life-threatening complications‑ is more than one hundred times greater in transplant patients living in areas of disease outbreak. [More]
Experts call on U.S. and Mexican governments to reduce risk of Chagas disease

Experts call on U.S. and Mexican governments to reduce risk of Chagas disease

Chagas disease -- the third most common parasitic infection in the world -- affects approximately 7.5 million people, mostly in Latin America. To help reduce outbreaks of this disease in their countries, the United States and Mexican governments should implement a range of programs as well as fund research for the development of Chagas vaccines and treatments, according to a new policy brief by tropical-disease and science policy experts at Rice University's Baker Institute for Public Policy. [More]
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