Ubiquitin News and Research

RSS

Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Researchers create new platform to identify proteins for targeted treatment of disease

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

22 Mar 2024

Clay Wright awarded prestigious MIRA funding for engineering common cellular signals

Clay Wright, assistant professor in the College of Agriculture and Life Sciences' Department of Biological Systems Engineering, was awarded a prestigious Maximizing Investigators' Research Award from the National Institute of General Medical Sciences, part of the National Institutes of Health.

14 Mar 2024

Discovery of new organelle could improve the understanding of chronic liver diseases

Scientists have identified a new organelle in liver cells called the mitochondria-lysosome-related organelle (MLRO).

12 Mar 2024

Ubiquigent enters agreement with Astellas subsidiary, Nanna Therapeutics

Agreement leverages Ubiquigent’s DUB-focused drug discovery platform to support the development of novel therapeutic candidates for multiple disease targets selected by Nanna Therapeutics.

From Ubiquigent Limited 11 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Scientists at EPFL uncover the mechanism by which cells mark the protein cGAS for degradation, which is critical in preventing the immune system from mistakenly attacking the body's own tissues.

28 Feb 2024

Unlocking coronavirus structure through M protein research

For centuries, coronaviruses have triggered health crises and economic challenges, with SARS-CoV-2, the coronavirus that spreads COVID-19, being a recent example.

28 Feb 2024

New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

The pathophysiological mechanisms of PI myalgic encephalitis/chronic fatigue syndrome (ME/CFS).

23 Feb 2024

Intramolecular bivalent glues: A promising avenue for protein degradation

Living cells resemble highly organized small towns - in addition to energy production, transportation systems, and construction, cells also require efficient waste disposal.

21 Feb 2024

Molecular glue could pave the way for new generation of drugs

A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and neurodegenerative diseases.

21 Feb 2024

Study uncovers critical roles for USP1 in Ewing sarcoma

A new research paper was published in Genes & Cancer on February 5, 2024, entitled, "Roles of USP1 in Ewing sarcoma."

14 Feb 2024

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

OHSU study sheds light on ubiquitin modification during bacterial infection

New research from Oregon Health & Science University could one day lead to therapies that prevent or treat diseases and infections tied to a protein that's found in all human cells.

12 Dec 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Common chemical label shields proteins from degradation

Researchers from the University of Bergen (UiB) have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

27 Oct 2023

New discovery sheds light on how BRCA1 mutations cause cancer in women

Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has pinpointed the molecular mechanism by which a large portion of these mutations cause cancers in women.

9 Oct 2023

Unveiling the role of astrocyte-derived LCN2 in neurodegenerative disease progression

Researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2).

4 Oct 2023

Ubiquigent collaborates with Imperial College London on DUB probe discovery to facilitate preclinical and clinical target engagement studies

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a PhD student in the Institute of Chemical Biology EPSRC Centre for Doctoral Training (CDT) in Chemical Biology, at Imperial College London.

From Ubiquigent Limited 4 Oct 2023

New insights into the molecular mechanism of protein degradation

Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease.

22 Sep 2023