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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.
UT Southwestern researcher named recipient of ASBMB Merck Award for research on molecular biology

UT Southwestern researcher named recipient of ASBMB Merck Award for research on molecular biology

Dr. Zhijian "James" Chen, Professor of Molecular Biology and a Howard Hughes Medical Institute investigator at UT Southwestern Medical Center, has been named the 2015 recipient of the American Society for Biochemistry and Molecular Biology Merck Award, which recognizes outstanding contributions to research in biochemistry and molecular biology. [More]
Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Alzheimer's disease affects approximately 5.2 million people in the United States alone, and it is the nation's sixth leading cause of death. [More]
New study sheds light on role of RPM-1 protein in neuron development

New study sheds light on role of RPM-1 protein in neuron development

In a new study, scientists from the Florida campus of The Scripps Research Institute have shed new light on these complex processes, showing that a particular protein plays a far more sophisticated role in neuron development than previously thought. [More]
Research uncovers how complex protein pivotal in cancer development is activated

Research uncovers how complex protein pivotal in cancer development is activated

New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated. [More]
Keck Medicine of USC study identifies potential therapeutic target for inflammation

Keck Medicine of USC study identifies potential therapeutic target for inflammation

Molecular microbiologists from the Keck School of Medicine of the University of Southern California have discovered that mice lacking a specific component of the immune system are completely resistant to sepsis, a potentially fatal complication of infection. [More]
Scientists find a new strategy for brain cancer treatment

Scientists find a new strategy for brain cancer treatment

Scientists at the Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumour cells multiply uncontrollably, especially in the case of glioblastoma. T [More]
Research reveals key aspect of protein regulation in cells

Research reveals key aspect of protein regulation in cells

St. Jude Children's Research Hospital scientists have discovered how an important "on" switch is attached to the machinery that cells rely on to adapt thousands of proteins to meet changing conditions. [More]
Researchers figure out way to disable a part of SARS virus

Researchers figure out way to disable a part of SARS virus

A Purdue University-led research team has figured out how to disable a part of the SARS virus responsible for hiding it from the immune system; a critical step in developing a vaccine against the deadly disease. [More]
New research shows how misfolded proteins are precisely selected for degradation

New research shows how misfolded proteins are precisely selected for degradation

It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood. [More]
Study of rare childhood neurodegenerative diseases identifies new source of DNA damage

Study of rare childhood neurodegenerative diseases identifies new source of DNA damage

St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging. [More]
Rice University research targets Parkinson's, Huntington's and other proteasomal diseases

Rice University research targets Parkinson's, Huntington's and other proteasomal diseases

Synthetic genetic circuitry created by researchers at Rice University is helping them see, for the first time, how to regulate cell mechanisms that degrade the misfolded proteins implicated in Parkinson's, Huntington's and other diseases. [More]
Professor receives $1.7M NIH grant to explore novel treatments for chronic methamphetamine users

Professor receives $1.7M NIH grant to explore novel treatments for chronic methamphetamine users

A Wayne State University professor recently received a nearly $1.7 million grant from the National Institutes of Drug Abuse of the National Institutes of Health to explore whether proteasome and parkin — two components of the ubiquitin-proteasome system — are potential pharmaceutical drug targets that can be manipulated to promote survival and recovery of dopaminergic terminals after binge and chronic administration of toxic doses of methamphetamine. [More]
Bio-Techne makes $10M equity investment in CyVek

Bio-Techne makes $10M equity investment in CyVek

Techne Corporation, d/b/a Bio-Techne, announced today that it has made a $10 million equity investment in CyVek, Inc. (CyVek), with a commitment to acquire CyVek if certain future milestones are met. [More]
Sanford-Burnham to present new cancer research data at AACR 2014

Sanford-Burnham to present new cancer research data at AACR 2014

Sanford-Burnham Medical Research Institute will present a wide range of new research data at the annual American Association for Cancer Research Meeting in San Diego starting Saturday, April 5, at the San Diego Convention Center. The presentations will cover a variety of topics including breast, melanoma, and prostate cancer, as well as novel methods of delivering drugs to tumors. [More]
Researchers find potential way to ease physical damage of numerous genetic disorders

Researchers find potential way to ease physical damage of numerous genetic disorders

Duke Medicine researchers studying tiny, antennae-like structures called cilia have found a potential way to ease some of the physical damage of numerous genetic disorders that result when these essential cellular components are defective. [More]
Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

Researchers from North Carolina State University have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers. [More]
New RUB project to unravel role of enzyme Parkin in promoting neuronal survival

New RUB project to unravel role of enzyme Parkin in promoting neuronal survival

Cell biologists at the Ruhr-Universit-t Bochum have launched a new project to unravel the role of the enzyme Parkin in promoting neuronal survival. The team of Prof Dr Konstanze F. Winklhofer from the Institute of Physiological Chemistry, Department of Molecular Cell Biology, is looking for new therapeutic options to treat Parkinson's disease. The Michael J. Fox Foundation finances this research project with 125,000 US Dollars. [More]
New research reveals how high-protein diet reduces muscle loss when dieting

New research reveals how high-protein diet reduces muscle loss when dieting

Building upon the discovery that a high-protein diet reduces muscle loss when dieting, a new research report published online in The FASEB Journal now helps explain why. Protein consumption slows the ubiquitin proteasome system, which is primarily responsible for degrading skeletal muscle. [More]
Enzyme intervenes when cancer-fighting PTEN is bound for cell's protein-destroying machinery

Enzyme intervenes when cancer-fighting PTEN is bound for cell's protein-destroying machinery

​A protector for PTEN, a tumor-thwarting protein often missing in cancer cells, has emerged from research led by scientists at The University of Texas MD Anderson Cancer Center published online at Nature Cell Biology this week. [More]
Researchers report long-term benefits of gene therapy in advanced heart failure patients

Researchers report long-term benefits of gene therapy in advanced heart failure patients

Researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai reported the long-term benefits of a single dose of their gene therapy AAV1/SERCA2a in advanced heart failure patients on Nov. 19 at the American Heart Association Scientific Sessions 2013. [More]