Ulcerative Colitis News and Research

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Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
Human colon organoids fill gap in effectively modeling common GI diseases

Human colon organoids fill gap in effectively modeling common GI diseases

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

Children suffering from IBD not meeting daily recommended intake of calcium and vitamin D

Children suffering from IBD not meeting daily recommended intake of calcium and vitamin D

New study finds dramatic reorganization of the gut caused by weight loss surgery

New study finds dramatic reorganization of the gut caused by weight loss surgery

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Microbes can manipulate molecular machinery of host cells to influence health

Microbes can manipulate molecular machinery of host cells to influence health

Scientists identify gene linked to incurable bowel disorders

Scientists identify gene linked to incurable bowel disorders

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Researchers discover that microRNA can prevent excessive intestinal inflammation

Researchers discover that microRNA can prevent excessive intestinal inflammation

Stress management may be promising strategy to treat abdominal pain in IBD patients

Stress management may be promising strategy to treat abdominal pain in IBD patients

Study shows how probiotic improves integrity of the GI epithelial cell wall in HIV patients

Study shows how probiotic improves integrity of the GI epithelial cell wall in HIV patients

Study shows safety, efficacy of endoscopic needle knife therapy for intestinal strictures in IBD patients

Study shows safety, efficacy of endoscopic needle knife therapy for intestinal strictures in IBD patients

Researchers discover new mechanism that causes chronic intestinal inflammation

Researchers discover new mechanism that causes chronic intestinal inflammation

Pairing curcumin with turmeric essential oils offers better protection from ulcerative colitis, study finds

Pairing curcumin with turmeric essential oils offers better protection from ulcerative colitis, study finds

Fecal microbiota transplant may be effective treatment option for ulcerative colitis, research suggests

Fecal microbiota transplant may be effective treatment option for ulcerative colitis, research suggests

Dietary soy-protein may be effective adjunct therapy for inflammatory bowel diseases

Dietary soy-protein may be effective adjunct therapy for inflammatory bowel diseases

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients