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Unique attributes of zebrafish may help study human blood disorders

Unique attributes of zebrafish may help study human blood disorders

Genetic regulation of the various types of blood cells in zebrafish and humans is highly similar, making it relatively easy and cost-effective to perform genetic, chemical, imaging and other molecular studies on this invaluable model organism to study normal hematopoetic development in humans as well as blood disorders and malignancies, as described in a Review article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
Globin gene transfer to treat beta-thalassemias shows promise in first clinical trial

Globin gene transfer to treat beta-thalassemias shows promise in first clinical trial

Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals. [More]
Climate change, global travel may increase dengue epidemic risk

Climate change, global travel may increase dengue epidemic risk

Researchers at Umea University have developed a model for evidence-based predictions of the mosquito-borne dengue virus. Results show that global travel and climate change increase the risk for epidemics of dengue, and potentially other climate-sensitive infectious diseases carried by mosquitos, spreading into temperate areas. This according to a doctoral dissertation at Umeå University. [More]
WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

During World Immunization Week 2016, held 24-30 April, the World Health Organization highlights recent gains in immunization coverage, and outlines further steps countries can take to “Close the Immunization Gap” and meet global vaccination targets by 2020. [More]
Warming temperatures may increase risk for dengue outbreaks in Europe

Warming temperatures may increase risk for dengue outbreaks in Europe

Increasing temperatures will enlarge Europe's seasonal window for the potential spread of mosquito-borne viral disease, expanding the geographic areas at risk for a dengue epidemic to include much of Europe. The findings by researchers at Umea University in Sweden are published in the journal EBioMedicine. [More]
Unlocking intrinsically disordered proteins: an interview with Peter Wright

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years. [More]
Zepatier receives FDA approval for treatment of chronic HCV genotypes 1 and 4 infections

Zepatier receives FDA approval for treatment of chronic HCV genotypes 1 and 4 infections

The U.S. Food and Drug Administration today approved Zepatier (elbasvir and grazoprevir) with or without ribavirin for the treatment of chronic hepatitis C virus (HCV) genotypes 1 and 4 infections in adult patients. [More]
Leading researchers reject proposed link between adeno-associated virus 2 and hepatocellular carcinoma

Leading researchers reject proposed link between adeno-associated virus 2 and hepatocellular carcinoma

The conclusion drawn from a recent study that insertion of adeno-associated virus 2 (AAV2) into human DNA causes mutations leading to the development of hepatocellular carcinoma (HCC) was resoundingly rejected by leading researchers in the fields of gene therapy and molecular genetics. [More]
Measles vaccination plays key role in reducing child mortality

Measles vaccination plays key role in reducing child mortality

The number of measles-related deaths has decreased 79% from 546 800 at the beginning of the century to 114 900 in 2014. New data released by WHO for the Measles & Rubella Initiative, estimates that 17.1 million lives have been saved since 2000, largely due to increased vaccination coverage against this highly contagious viral disease. [More]
First-ever genomic study shows dengue may survive year-round in southern China

First-ever genomic study shows dengue may survive year-round in southern China

The first-ever comprehensive genomic analysis of the virus that causes dengue fever suggests that it may survive year-round in southern China. [More]
Gene therapy restores visual function in mouse model of LCA1

Gene therapy restores visual function in mouse model of LCA1

Mice lacking the protein retGC1, which is deficient in humans suffering Leber congenital amaurosis-1 (LCA1), a disorder that causes severe visual impairment beginning in infancy, received gene therapy to replace retGC1 and showed fully restored visual function that persisted for at least 6 months. [More]
60P to commence Phase II clinical trial among dengue fever patients

60P to commence Phase II clinical trial among dengue fever patients

60 Degrees Pharmaceuticals, a company focused on development of therapeutics for tropical diseases, and Singapore General Hospital announced today that the Hospital has received a grant from Singapore's National Medical Research Council to support a Phase II clinical trial among dengue fever patients. [More]
Ledipasvir/sofosbuvir combination approved for hepatitis C treatment does not require antiviral drug

Ledipasvir/sofosbuvir combination approved for hepatitis C treatment does not require antiviral drug

The drug approved to treat patients infected with the hepatitis C virus needs no help from other antivirals, according to a study released online this week in the journal Hepatology. [More]
Two South Dakota State University researchers awarded NASA grant to combat West Nile virus

Two South Dakota State University researchers awarded NASA grant to combat West Nile virus

Through a three-year NASA grant, two South Dakota State University researchers will help mosquito control officials use mosquito surveillance and environmental data to target West Nile virus. [More]

BRIM, Janssen announce strategic collaboration to develop effective treatment for dengue

BRIM Biotechnology, Inc., announced today that it has entered a Collaboration, Option and License Agreement with Janssen Pharmaceutica N.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson. [More]
MIPT researchers develop ultrasensitive nanomechanical sensor to identify tumor markers

MIPT researchers develop ultrasensitive nanomechanical sensor to identify tumor markers

Two young researchers working at the MIPT Laboratory of Nanooptics and Plasmonics, Dmitry Fedyanin and Yury Stebunov, have developed an ultracompact highly sensitive nanomechanical sensor for analyzing the chemical composition of substances and detecting biological objects, such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others. [More]
AWMSG recommends Daklinza (daclatasvir) for treatment of adult patients with chronic HCV infection

AWMSG recommends Daklinza (daclatasvir) for treatment of adult patients with chronic HCV infection

The All Wales Medicines Strategy Group has recommended Daklinza (daclatasvir) for the treatment of adult patients with chronic hepatitis C virus (HCV) infection. The recommendation is specifically for patients with advanced liver disease, for whom treatment options can be limited. [More]
Liberia conducts first polio, measles immunizations since Ebola outbreak.

Liberia conducts first polio, measles immunizations since Ebola outbreak.

A week-long campaign to vaccinate more than 600,000 children against polio and measles kicks off today in Liberia... [More]
International science team pave way for fast and accurate diagnosis of the influenza virus

International science team pave way for fast and accurate diagnosis of the influenza virus

Statistics indicate that, on average, adults over the age of 30 only contract the influenza virus twice in a decade – but far more frequently (self) misdiagnose a cold virus (commonly rhinovirus or coronavirus) as being the flu... [More]
New review highlights future research initiatives to eradicate polio

New review highlights future research initiatives to eradicate polio

April 12th 2015 marks the 60th anniversary of the publication of Jonas Salk's landmark polio vaccine trial results, which confirmed that the first vaccine against polio was safe and effective. A new review, which was published online ahead of print in Future Microbiology, provides a comprehensive overview of current polio vaccines, and highlights new and future research initiatives, such as new vaccine formulations, that could help ensure that polio is eradicated and eradication is maintained. [More]
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