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Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial. [More]
PYY hormone may offer effective treatment for type 2 diabetes

PYY hormone may offer effective treatment for type 2 diabetes

Researchers at the Norwegian University of Science and Technology and Oxford University have found a hormone that may offer an effective treatment for type 2 diabetes. [More]
Exercise plays significant role in combating obesity

Exercise plays significant role in combating obesity

Two factors—metabolism and gut microbes - have been credited by researchers as key players in the fight against obesity. [More]
Carol Fabian inducted into KU Women's Hall of Fame for contributions to breast cancer research

Carol Fabian inducted into KU Women's Hall of Fame for contributions to breast cancer research

Among the women inducted into the University of Kansas Hall of Fame on April 14, 2016, was Carol Fabian, MD. Fabian, a professor of medicine at the University of Kansas Medical Center and director of the Breast Cancer Prevention Center at The University of Kansas Cancer Center, is a nationally recognized oncologist and a pioneer in in the field of breast cancer research. [More]
Neos announces U.S. launch of Adzenys XR-ODT for ADHD

Neos announces U.S. launch of Adzenys XR-ODT for ADHD

Neos Therapeutics, Inc., a pharmaceutical company with a late‐stage pipeline of innovative extended-release (XR) product candidates for the treatment of attention-deficit/hyperactivity disorder (ADHD), today announced that Adzenys XR-ODT™ is in distribution channels and is now available to prescribe for patients with ADHD in the United States. [More]
Boehringer Ingelheim presents new data on OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF)

Boehringer Ingelheim presents new data on OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF)

New analyses presented at the American Thoracic Society’s 2016 annual conference (ATS 2016) further add to the efficacy and safety profile of OFEV® (nintedanib) in idiopathic pulmonary fibrosis (IPF). [More]
Sleeve gastrectomy can give optimal outcomes even in sweet eaters

Sleeve gastrectomy can give optimal outcomes even in sweet eaters

Sleeve gastrectomy is a novel bariatric surgical procedure showing promising weight loss results, even among individuals classified as moderate or severe sweet eaters before the surgery. [More]
Physical movements improve in patients after bariatric surgery

Physical movements improve in patients after bariatric surgery

People who have their stomach size surgically reduced move around more and easier after weight loss surgery, a study has found. [More]
NHS needs to increase rates of bariatric surgery to control obesity levels, say experts

NHS needs to increase rates of bariatric surgery to control obesity levels, say experts

The NHS should significantly increase rates of weight loss surgery to 50,000 a year, closer to the European average, to bring major health benefits for patients and help reduce healthcare costs in the long term, argue experts in The BMJ this week. [More]
Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

A major type of inflammatory bowel disease (IBD) may be caused in part by genetic variants that prevent beneficial bacteria in the gut from doing their job, according to a new study published today in the journal Science. [More]
Dieting may suppress metabolism even after weight gain

Dieting may suppress metabolism even after weight gain

While it's known that metabolism slows when people diet, new research indicates that metabolism remains suppressed even when people regain much of the weight they lost while dieting. [More]
Scientists discover how immune system molecule hijacks brain circuit to reduce appetite during illness

Scientists discover how immune system molecule hijacks brain circuit to reduce appetite during illness

Loss of appetite during illness is a common and potentially debilitating phenomenon--in cancer patients, especially, it can even shorten lifespan. [More]
Simple 20-second upper arm extension test can identify frailty in older adults

Simple 20-second upper arm extension test can identify frailty in older adults

A simple arm test that employs a novel wearable technology can rapidly and accurately identify physiological frailty in older adults, according to study results published online in the Journal of the American College of Surgeons in advance of print publication. [More]
Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Experimental drug ozanimod moderately effective in treatment of ulcerative colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine. [More]
Bayer-new phase 3 liver cancer data

Bayer-new phase 3 liver cancer data

Bayer has announced that a Phase III trial evaluating its oncology compound Stivarga® (regorafenib) tablets for the treatment of patients with unresectable hepatocellular carcinoma (HCC) has met its primary endpoint of a statistically significant improvement in overall survival. The study, called RESORCE, evaluated the efficacy and safety of regorafenib in patients with HCC whose disease has progressed after treatment with sorafenib. The safety and tolerability were generally consistent with the known profile of regorafenib. Detailed efficacy and safety analyses from this study are expected to be presented at an upcoming scientific congress. [More]
Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Controlling cholesterol metabolism could help reduce pancreatic cancer spread

Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis, pointing to a potential new treatment using drugs previously developed for atherosclerosis. [More]
New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

New nanoparticle approach can deliver antiobesity drugs directly to fat tissue

Researchers at MIT and Brigham and Women's Hospital have developed nanoparticles that can deliver antiobesity drugs directly to fat tissue. Overweight mice treated with these nanoparticles lost 10 percent of their body weight over 25 days, without showing any negative side effects. [More]
Half-strength apple juice followed by preferred fluid choice better for treating kids with mild gastroenteritis

Half-strength apple juice followed by preferred fluid choice better for treating kids with mild gastroenteritis

Children with mild gastroenteritis and minimal dehydration experienced fewer treatment failures such as IV rehydration or hospitalization when offered half-strength apple juice followed by their preferred fluid choice compared with children who received electrolyte maintenance solution to replace fluid losses, according to a study published online by JAMA. The study is being released to coincide with its presentation at the Pediatric Academic Societies meeting. [More]
Older women with chronic health problems more likely to have lower quality of life

Older women with chronic health problems more likely to have lower quality of life

Researchers writing in the Journal of the American Geriatrics Society recently learned that older women who are frail, and who have six or more chronic health conditions, are twice as likely to have a lower quality of life compared to women with less than three risk factors. [More]
Assessing body composition may help predict cardiovascular and total mortality

Assessing body composition may help predict cardiovascular and total mortality

Researchers from the David Geffen School of Medicine at UCLA found that cardiovascular disease patients who have high muscle mass and low fat mass have a lower mortality risk than those with other body compositions. The findings also suggest that regardless of a person's level of fat mass, a higher level of muscle mass helps reduce the risk of death. [More]
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