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Brain atrophy patterns linked to loss of specific cognitive abilities in patients with Alzheimer's disease

Brain atrophy patterns linked to loss of specific cognitive abilities in patients with Alzheimer's disease

Mathematical modeling of the brain scans of patients with Alzheimer's disease and others at risk for the devastating neurodegenerative disorder has identified specific patterns of brain atrophy that appear to be related to the loss of particular cognitive abilities. [More]
Abnormal protein in the brain may play important role in development of Alzheimer's disease

Abnormal protein in the brain may play important role in development of Alzheimer's disease

A recently-recognized pathologic protein in the brain may play a larger role in the development of clinical Alzheimer's disease dementia than previously recognized, according to a study by researchers at Rush University Medical Center. [More]
GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

Georgetown University Medical Center today announces the U.S. Food and Drug Administration has completed its review of an investigational new drug application (IND) for the use of nilotinib in a phase II clinical trial for patients with mild to moderate Alzheimer's disease. [More]
ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

The Alzheimer's Drug Discovery Foundation announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna for use as a cancer therapy) in patients with Alzheimer's disease. [More]
Monoclonal antibody removes brain amyloid plaques in patients with Alzheimer's disease

Monoclonal antibody removes brain amyloid plaques in patients with Alzheimer's disease

Scientists at Neurimmune today described results from the Phase 1b PRIME clinical trial of the monoclonal antibody aducanumab. [More]
Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer's, appear to also contribute to the disease, scientists report. [More]
Salk researchers identify new mechanism for Alzheimer's risk gene

Salk researchers identify new mechanism for Alzheimer's risk gene

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population. [More]
Healthy BMI, exercise and diet can lower abnormal protein build-ups linked to Alzheimer’s

Healthy BMI, exercise and diet can lower abnormal protein build-ups linked to Alzheimer’s

A study by researchers at UCLA's Semel Institute for Neuroscience and Human Behavior has found that a healthy diet, regular physical activity and a normal body mass index can reduce the incidence of protein build-ups that are associated with the onset of Alzheimer's disease. [More]
Researchers describe structure of Alzheimer fibrils at atomic resolution

Researchers describe structure of Alzheimer fibrils at atomic resolution

Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer's disease. [More]
Lower weight late in life linked to greater risk for Alzheimer's disease

Lower weight late in life linked to greater risk for Alzheimer's disease

Researchers at Brigham and Women's Hospital and Massachusetts General Hospital have found an association between lower weight and more extensive deposits of the Alzheimer's-associated protein beta-amyloid in the brains of cognitively normal older individuals. [More]
Odor identification test may help detect early-stage Alzheimer's disease

Odor identification test may help detect early-stage Alzheimer's disease

Researchers from Columbia University Medical Center, New York State Psychiatric Institute, and NewYork-Presbyterian reported that an odor identification test may prove useful in predicting cognitive decline and detecting early-stage Alzheimer's disease. [More]
17beta-Estradiol patch may help reduce Alzheimer's disease risk in newly postmenopausal women

17beta-Estradiol patch may help reduce Alzheimer's disease risk in newly postmenopausal women

Can estrogen preserve brain function and decrease the risk of Alzheimer's disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer's disease, a Mayo Clinic study published this month in the Journal of Alzheimer's Disease found. [More]
Researchers make successful vaccine formulation that targets proteins linked to Alzheimer’s disease

Researchers make successful vaccine formulation that targets proteins linked to Alzheimer’s disease

With more than 7.5 million new cases of Alzheimer’s disease a year, the race to find a vaccine and effective treatment for dementia is growing by the day. [More]
TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

Traumatic brain injury (TBI) with a loss of consciousness (LOC) may be associated with later development of Parkinson's disease but not Alzheimer's disease or incident dementia, according to a study conducted at the Icahn School of Medicine at Mount Sinai and the University of Washington School of Medicine. [More]
New mouse model reveals how Alzheimer's causes dementia

New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease. [More]
New imaging study links tau proteins to neurodegenerative pathology of Alzheimer's disease

New imaging study links tau proteins to neurodegenerative pathology of Alzheimer's disease

Alzheimer's is a devastating and incurable disease marked by beta-amyloid and tau protein aggregations in the brain, yet the direct relationship between these proteins and neurodegeneration has remained a mystery. [More]
Measuring specific proteins in blood samples may help track progression of dementias

Measuring specific proteins in blood samples may help track progression of dementias

Reliable information can be obtained on the progression of dementias by measuring specific proteins in the blood and cerebrospinal fluid. A test of this kind is especially significant to the development of new therapies, as reported in the journal Neuron by scientists from the University of Basel and University Hospital Basel, along with international colleagues. [More]
Alzheimer’s research raises questions on the role of infection

Alzheimer’s research raises questions on the role of infection

A new study has shown that A-beta (Aβ), the protein that forms β-amyloid plaques in Alzheimer’s disease, is a normal part of the immune system - raising questions about the role infection plays in Alzheimer’s disease and whether current treatment strategies should be changed. [More]
Mice study shows heart medication helps reduce build-up of plaque in brain's blood vessels

Mice study shows heart medication helps reduce build-up of plaque in brain's blood vessels

A new study from örebro University, published in Science Signaling today, shows that heart medication reduces the build-up of plaque in the brain's blood vessels in mice. The question is if this is true also in humans? If the answer is yes, it might bring scientists a step closer to developing a medicine against Alzheimer's disease. [More]
Tau pathology closely tracks brain function during early AD

Tau pathology closely tracks brain function during early AD

Tau tangles may be a better indicator of cognitive changes during Alzheimer's disease progression than beta-amyloid deposition, researchers propose. [More]
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