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Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Could a kinase inhibitor some doctors prescribe to keep blood flowing after brain surgery be used to treat neurodegeneration? New research suggests it might be worth exploring the question. [More]
Anemia associated with increased risk of mild cognitive impairment

Anemia associated with increased risk of mild cognitive impairment

In a large population-based study of randomly selected participants in Germany, researchers found that participants with anemia, defined as haemoglobin <13 g/dl in men and <12 g/dl in women, showed lower performances in verbal memory and executive functions. [More]
Zecotek Photonics receives order for patented LFS scintillation crystals

Zecotek Photonics receives order for patented LFS scintillation crystals

Zecotek Photonics Inc., a developer of leading-edge photonics technologies for industrial, healthcare and scientific markets, is pleased to announce that it has received an order for its patented Lutetium Fine Silicate (LFS) scintillation crystals from a specialized medical imaging device manufacturer based in the United States. [More]
Scientists identify new jelly-like properties of essential proteins that lead to serious diseases

Scientists identify new jelly-like properties of essential proteins that lead to serious diseases

Scientists at the University of Cambridge have identified a new property of essential proteins which, when it malfunctions, can cause the build up, or 'aggregation', of misshaped proteins and lead to serious diseases. [More]
Routine clinical features may aid BVFTD diagnostic accuracy

Routine clinical features may aid BVFTD diagnostic accuracy

Researchers have identified clinical features that can help determine which patients assessed for behavioural variant frontotemporal dementia are most likely to actually have the condition. [More]
Findings could lead to new treatment for ALS, dementia

Findings could lead to new treatment for ALS, dementia

University of Toronto (U of T) researchers are proposing a new way of understanding Amyotrophic Lateral Sclerosis (ALS), the devastating and incurable neurological disease. Their findings, published today in the journal Neuron, could be a major milestone on the path to a treatment for both ALS and dementia. [More]
U of T study provides hope for treating ALS and FTD

U of T study provides hope for treating ALS and FTD

It's the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but until now scientists weren't sure how a specific gene caused these devastating diseases. Now researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment. [More]
Research highlights potential new treatment strategy for degenerative diseases

Research highlights potential new treatment strategy for degenerative diseases

St. Jude Children's Research Hospital scientists have discovered evidence of a mechanism at the heart of amyotrophic lateral sclerosis (ALS) and related degenerative diseases. The research appears in today's edition of the journal Cell and highlights a possible new treatment strategy for the devastating disorders. [More]
Salsalate drug offers new hope for treating Alzheimer's disease and FTD

Salsalate drug offers new hope for treating Alzheimer's disease and FTD

Scientists from the Gladstone Institutes have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia (FTD). Salsalate prevented the accumulation of tau in the brain and protected against cognitive impairments resembling impairments seen in Alzheimer's disease and FTD. [More]
Common gene mutation may cause brain damage associated with ALS and FTD

Common gene mutation may cause brain damage associated with ALS and FTD

Johns Hopkins researchers say they have discovered some of the first steps in how a very common gene mutation causes the brain damage associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). [More]
Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers have determined how the most common gene mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disrupts normal cell function, providing insight likely to advance efforts to develop targeted therapies for these brain diseases. [More]
Others consider our moral traits, not memory, to be core component of our identity

Others consider our moral traits, not memory, to be core component of our identity

We may view our memory as being essential to who we are, but new findings suggest that others consider our moral traits to be the core component of our identity. Data collected from family members of patients suffering from neurodegenerative disease showed that it was changes in moral behavior, not memory loss, that caused loved ones to say that the patient wasn't "the same person" anymore. [More]
Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

Autopsies of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral sclerosis (ALS), and many with frontotemporal dementia (FTD), show pathologists telltale clumps of a protein called TDP-43. Now, working with mouse and human cells, Johns Hopkins researchers report they have discovered the normal role of TDP-43 in cells and why its abnormal accumulation may cause disease. [More]
Alzheimer's Association recognizes four scientists with Lifetime Achievement Awards at AAIC 2015

Alzheimer's Association recognizes four scientists with Lifetime Achievement Awards at AAIC 2015

The Alzheimer's Association recognizes four leading scientists for their contributions to advancing Alzheimer's disease and dementia research. The awards were presented during the opening session at the Alzheimer's Association International Conference 2015 in Washington, D.C. [More]
U of T researchers discover new details about key gene involved in ALS

U of T researchers discover new details about key gene involved in ALS

A University of Toronto research team has discovered new details about a key gene involved in ALS, perhaps humanity's most puzzling, intractable disease. [More]
Early neuronal lysosomal dysfunction could help predict AD

Early neuronal lysosomal dysfunction could help predict AD

Blood levels of altered lysosomal proteins may help detect preclinical Alzheimer’s disease, researchers report. [More]
Specialized brain proteins may be detected in the blood samples of individuals with Alzheimer's disease

Specialized brain proteins may be detected in the blood samples of individuals with Alzheimer's disease

Specialized brain proteins that are involved in the removal of damaged nerve cell materials may be detected in the blood of people who were diagnosed with mild cognitive impairment or dementia due to Alzheimer's disease. [More]
People with cognitive impairment have altered responses to pain

People with cognitive impairment have altered responses to pain

People with dementia and other forms of cognitive impairment (CI) have altered responses to pain, with many conditions associated with increased pain sensitivity, concludes a research review in PAIN, the official publication of the International Association for the Study of Pain. [More]
Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Mayo Clinic scientists create mouse model of ALS, FTD caused by mutations in C9ORF72 gene

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72. [More]

Studies refine amyloid imaging role in dementia

Two meta-analyses published in JAMA help to define the role of amyloid imaging in dementia. [More]
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