microRNA News and Research RSS Feed - microRNA News and Research

In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.
Study suggests microRNAs may connect inflammation with heart disease risk in obese people

Study suggests microRNAs may connect inflammation with heart disease risk in obese people

Inflammation likely plays a role in the increased risk of heart disease that comes with obesity, but scientists don't fully understand how obesity leads to heart disease. [More]
Tel Aviv University researchers unravel how melanoma spreads to distant organs

Tel Aviv University researchers unravel how melanoma spreads to distant organs

In a landmark discovery, researchers at Tel Aviv University have unraveled the metastatic mechanism of melanoma, the most aggressive of all skin cancers. [More]
Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

Annually about 2000 Danish patients with colorectal cancer are treated with chemotherapy. Today, a range of different chemotherapeutic regimens are available. However, deciding which regimen to use is not easy. [More]
UH biologists developing strategies to help regenerate heart muscle cell formation

UH biologists developing strategies to help regenerate heart muscle cell formation

Cardiovascular diseases are the leading cause of death in the U.S. With one in every four deaths occurring each year, the five-year survival rate after a heart attack is worse than most cancers. [More]
Scientists discover tissue biomarkers that lead to joint degeneration linked to spine osteoarthritis

Scientists discover tissue biomarkers that lead to joint degeneration linked to spine osteoarthritis

A research team at the Krembil Research Institute has discovered a pair of tissue biomarkers that directly contribute to the harmful joint degeneration associated with spine osteoarthritis. [More]
Battling IBD with super heroes: an interview with Dr James Lindsay

Battling IBD with super heroes: an interview with Dr James Lindsay

Takeda Pharmaceutical Company Limited has launched IBD Unmasked as a first-of-its-kind global initiative designed to raise awareness of the unsung Super Heroes of the global IBD community. [More]
New research opens door to influencing immune system

New research opens door to influencing immune system

A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis. [More]
Adhesive patch can deliver triple combination therapy to tumor sites

Adhesive patch can deliver triple combination therapy to tumor sites

Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in the U.S. In Europe, it is the second-most common form of cancer. [More]
Researchers unveil engineered protein to suppress cancer-promoting message within cells

Researchers unveil engineered protein to suppress cancer-promoting message within cells

Over a century of research has shined light on the once-murky innards of our cells, from the genes that serve as our "blueprints" to the proteins and other molecules that are our cellular taskmasters. [More]
Researchers demonstrate important functional role of lincRNA in immune system

Researchers demonstrate important functional role of lincRNA in immune system

A long non-coding RNA (lincRNA) - called lincRNA-EPS - responsible for regulating innate immunity has been identified by a team of scientists at the University of Massachusetts Medical School. [More]
Scientists identify viable new approach to making more stem cells from cord blood

Scientists identify viable new approach to making more stem cells from cord blood

International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr. Gerald de Haan, have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease. [More]
Study finds microRNA let-7 plays key role in restricting neuroblastoma

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Great strides have been made in treating neuroblastoma, the most common cancer in infants and toddlers. However, advanced cases are often fatal, and children who survive often face life-long physical and intellectual challenges related to their treatment. [More]
Study shows miR-19 helps new neurons in the adult brain stay on track

Study shows miR-19 helps new neurons in the adult brain stay on track

A small stretch of ribonucleic acid called microRNA could make the difference between a healthy adult brain and one that's prone to disorders including schizophrenia. [More]
Alnylam reports new results from investigational RNAi therapeutic programs

Alnylam reports new results from investigational RNAi therapeutic programs

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today preliminary results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, both investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis). [More]
Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer. [More]
Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Patients with an advanced disease often relapse due to the development of chemoresistance. Chemotherapy failure is a consequence of acquired drug resistance which may potentially be due to multiple mechanisms including miRNA-mediated gene regulation. [More]
MicroRNA plays role in blocking development of arterial thrombosis

MicroRNA plays role in blocking development of arterial thrombosis

The dangers of arterial thrombosis - the formation of blood clots that can block arteries and cause illness or death - can escalate through a vicious cycle of coagulation and inflammation. [More]
EPFL researchers reprogram TAMs to prevent tumor metastasis

EPFL researchers reprogram TAMs to prevent tumor metastasis

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis. [More]
RNA editing enzyme ADAR1 may play role in regeneration of leukemia stem cells

RNA editing enzyme ADAR1 may play role in regeneration of leukemia stem cells

Cancer stem cells are like zombies — even after a tumor is destroyed, they can keep coming back. These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors. [More]
Panel of microRNAs can predict patients at risk for developing HBV-driven liver cancer

Panel of microRNAs can predict patients at risk for developing HBV-driven liver cancer

Hepatocellular carcinoma, the most common type of liver cancer, is increasing in incidence in the United States, and infection with the Hepatitis B virus (HBV) causes about 50 percent of cases. [More]
Advertisement
Advertisement