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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.
New UCLA study finds that oxidized lipids may also contribute to pulmonary hypertension

New UCLA study finds that oxidized lipids may also contribute to pulmonary hypertension

Oxidized lipids are known to play a key role in inflaming blood vessels and hardening arteries, which causes diseases like atherosclerosis. A new study at UCLA demonstrates that they may also contribute to pulmonary hypertension, a serious lung disease that narrows the small blood vessels in the lungs. [More]
Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

Regulation of stem cells in zebrafish embryos results in surprising insights into Alzheimer's Disease

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. [More]
Scientists identify biomarker strongly associated with aggressive breast cancer

Scientists identify biomarker strongly associated with aggressive breast cancer

Two Northwestern University scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer. [More]
Seven physicians receive ASTRO grants to advance radiation oncology research

Seven physicians receive ASTRO grants to advance radiation oncology research

The American Society for Radiation Oncology has selected seven leading physicians to receive a total of $675,000 in awards and grants to advance radiation oncology research. The ASTRO Junior Faculty Career Research Training Award, the ASTRO Residents/Fellows in Radiation Oncology Research Seed Grant and the ASTRO/Radiation Oncology Institute Comparative Effectiveness Research Award will fund studies in radiation and cancer biology, radiation physics, translational research, outcomes/health services research and comparative effectiveness research within radiation oncology. [More]
Comprehensive database collecting information about microRNAs, multiMiR

Comprehensive database collecting information about microRNAs, multiMiR

Your genes are blueprints for proteins, and molecules called microRNA can help to determine how often these genetic blueprints are manufactured into proteins. Researchers often ask what microRNA regulates a gene related to disease. [More]
Sciatic nerve injury can cause differential expression of microRNAs in dorsal root ganglia

Sciatic nerve injury can cause differential expression of microRNAs in dorsal root ganglia

Slit-Robo GTPase-activating protein 3 contains a Rho GAP domain that regulates the activities of Rho family GTPases and affects actin polymerization, which influences dendrite elaboration, neurite outgrowth and axon guidance, contributing to neural regeneration. [More]
Researchers identify new biomarker that predicts effectiveness of glioblastoma treatment

Researchers identify new biomarker that predicts effectiveness of glioblastoma treatment

Researchers at the University of California, San Diego School of Medicine have identified a new biomarker that predicts whether glioblastoma - the most common form of primary brain cancer - will respond to chemotherapy. The findings are published in the July print issue of Oncotarget. [More]
Six-gene signature predicts survival after targeted therapy for NSCLC

Six-gene signature predicts survival after targeted therapy for NSCLC

The presence of a six-gene profile in the microRNA of patients with advanced non-squamous non-small-cell lung cancer predicts reduced survival likelihood after first-line treatment with targeted therapy followed by chemotherapy for disease progression, indicate research results. [More]
Weizmann Institute scientists 'fingerprint' a culprit in depression and anxiety disorders

Weizmann Institute scientists 'fingerprint' a culprit in depression and anxiety disorders

According the World Health Organization, such mood disorders as depression affect some 10% of the world's population and are associated with a heavy burden of disease. That is why numerous scientists around the world have invested a great deal of effort in understanding these diseases. Yet the molecular and cellular mechanisms that underlie these problems are still only partly understood. [More]
GENETICS and G3: Genes|Genomes|Genetics publish special collection on genetics of immunity

GENETICS and G3: Genes|Genomes|Genetics publish special collection on genetics of immunity

Immunity is what stops you dying from a common cold or a tiny pinprick. Differences in resistance or tolerance to disease influence who catches the bug that's going around the office, or which species succumb to the deadly fungus devastating frogs around the world. [More]
Researchers identify muscle-building mechanism that could be important in addressing sarcopenia

Researchers identify muscle-building mechanism that could be important in addressing sarcopenia

Sarcopenia - the significant loss of muscle mass and function that can occur as we age - is associated with many chronic conditions such as diabetes, high cholesterol and obesity. [More]
Study show good compliance and patient survival outcomes using LDCT screening protocol

Study show good compliance and patient survival outcomes using LDCT screening protocol

Investigators of the COSMOS (Continuous Observation of SMOking Subjects) study show good compliance and patient survival outcomes using a 5-year low-dose computed tomography (LDCT) screening protocol in individuals at high-risk of developing lung cancer. [More]
Mirna enrolls first patient in hematological malignancy cohort of MRX34 Phase 1 clinical trial

Mirna enrolls first patient in hematological malignancy cohort of MRX34 Phase 1 clinical trial

Mirna Therapeutics, Inc., a clinical-stage biopharmaceutical company pioneering microRNA-based Replacement Therapy to treat cancer, today announced the enrollment of the first patient in the hematological malignancy cohort of its ongoing Phase 1 clinical trial of MRX34, the company's lead product candidate and first microRNA mimic in human clinical trials in oncology. [More]
Alnylam announces new pre-clinical results with DC for ALN-CC5 to treat complement-mediated diseases

Alnylam announces new pre-clinical results with DC for ALN-CC5 to treat complement-mediated diseases

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today new pre-clinical results with its Development Candidate (DC) for ALN-CC5, a subcutaneously administered investigational RNAi therapeutic targeting complement component C5 in development for the treatment of complement-mediated diseases. [More]
Celsion signs definitive asset purchase agreement to acquire EGEN

Celsion signs definitive asset purchase agreement to acquire EGEN

Celsion Corporation (Celsion) (NASDAQ: CLSN), an oncology drug development company, and EGEN, Inc. (EGEN), a privately-held biopharmaceutical company focused on the development of nucleic acid-based therapeutics for the treatment of cancer and other difficult to treat diseases, today announced the signing of a definitive asset purchase agreement in which Celsion will acquire substantially all of the assets of EGEN, including its Phase Ib DNA-based immunotherapy product candidate EGEN-001 and its therapeutic platform technologies, TheraPlas™ for delivery of DNA and mRNA, TheraSilence™ for delivery of RNA, and RAST™ for Cell Enabled Expression and Secretion of RNA. [More]
Certain molecules in seminal fluid indicate presence and severity of prostate cancer

Certain molecules in seminal fluid indicate presence and severity of prostate cancer

Improved diagnosis and management of one of the most common cancers in men - prostate cancer - could result from research at the research at the University of Adelaide, which has discovered that seminal fluid (semen) contains biomarkers for the disease. [More]
Tiny molecule may provide marker for depression

Tiny molecule may provide marker for depression

Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute. [More]
Norgen launches 6 novel kits for simple isolation of NA from blood, plasma, serum, urine

Norgen launches 6 novel kits for simple isolation of NA from blood, plasma, serum, urine

Norgen Biotek Corp., an innovative privately held Canadian biotechnology company focusing primarily on advancing powerful tools for nucleic acids (NA) and protein purification, today announced the launch of 6 novel kits for the fast and simple isolation of NA from blood, plasma/serum and urine, including cell-free-circulating (cfc)RNA, cfcDNA and sequential cfcDNA and cfcRNA. [More]
Frost & Sullivan: Western European NGS market estimated to reach $697.3M in 2018

Frost & Sullivan: Western European NGS market estimated to reach $697.3M in 2018

The Western European next-generation sequencing (NGS) market is poised for steady growth, owing to the emergence of new applications such as non-invasive prenatal testing and comprehensive oncology panels. [More]

Researcher identify four new microRNAs involved in regulation of BDNF levels

Brain Derived Neurotrophic Factor (BDNF) regulates many processes including memory and learning in our daily tasks. [More]