The HeliScope™ Single Molecule Sequencer is the first genetic analyzer to harness the power of direct RNA and DNA measurements, enabled by Helicos True Single Molecule Sequencing (tSMS)™ and Direct RNA Sequencing (DRSTM) technologies. As the world’s first DNA/RNA microscope, the HeliScope instrument performs tSMS and DRS chemistries and captures images to observe sequencing-by-synthesis reactions for billions of individual DNA and RNA molecules in parallel.
Single molecule sequencing:
- Detects incorporation of individual bases on individual strands, eliminating the need for amplification and its associated biases and errors.
- Produces “digital data”, avoiding errors caused by de-phasing or intensity averaging techniques, and thereby generates consistently low error rates across all read lengths, resulting in high quality experiments.
- Offers simple sample preparation and high sample capacity per run, enabling you to combine different methods and applications in novel ways for a more complete understanding of the genome.