IN Cell Analyzer 6000 from GE Healthcare

IN Cell Analyzer 6000 is a high performance laser confocal imager designed for the most demanding high content assays and screens. Featuring a proprietary adjustable confocal imaging technology and a scientific-grade CMOS camera, IN Cell Analyzer 6000 is flexible enough to enable the wide variety of traditional HCA assays, as well as the more advanced applications that require increased imaging sensitivity or confocality.

  • Use the light efficient open aperture mode to boost imaging speed.
  • Use the adjustable confocal mode for background rejection, wash-free assays, and 3-D imaging.
  • Use the adjustable confocal mode for background rejection, wash-free assays, and 3-D imaging.
  • Optimize the degree of confocality for each fluorescent channel with a simple mouse click.

High Content Analysis (HCA) applications are focused on studies of a large variety of biological samples: small organisms, tissues, cell populations, and subcellular structures. Imaging of these samples can be challenging due to weak fluorescent signal, the presence of unwanted background fluorescence, and the complex 3D structure of a sample. Inspired by the iris mechanism of the eye, the proprietary optical system of IN Cell Analyzer 6000 provides high performance across a broad range of imaging conditions.

Most confocal HCA systems provide a non-adjustable aperture that is typically optimized for high power objectives. However, mid and low power objectives are often more enabling for HCA applications. The adjustable confocality of the IN Cell Analyzer 6000 optical system allows you to vary the confocal aperture width to match each specific imaging condition, enabling an optimal level of confocality, no matter which objective or excitation wavelength you require.

Sensitivity for Imaging Dim Assays

Powerful lasers for fluorescence excitation, a low noise scientific grade CMOS camera, and low light losses in the line confocal optics make IN Cell Analyzer 6000 a sensitive fluorescence imaging system, able to detect weak fluorescence signals that would typically be lost in the noise. As a result, high-quality images can be captured rapidly from dim biological samples. What’s more, highly uniform laser line illumination and optimized imaging optics eliminate the need to apply flat field correction for most imaging applications.

Throughput without Compromise

Adjustable confocality enables you to balance speed and image quality. The scientific-grade CMOS camera has a 4-fold larger field-of-view than a standard CCD camera, so fewer images need to be acquired to capture statistically robust cellular data. The highly sensitive camera coupled with laser-based illumination means exposure times are reduced, increasing imaging speed. Fast precision stages and rapid laser autofocus reduce non-imaging time.

Modular and Flexible

User-friendly acquisition features include preview scanning, manual microscopy mode, and whole-well imaging. Modules for environmental control, liquid handling, temperature control, transmitted light imaging and slide handling significantly extend the range of assays that can be performed

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