Real-Time Cell Analyzer (RTCA) HT Instrument from Roche

The RTCA HT Instrument is composed of four main components:

  • RTCA HT Station
  • RTCA HT Analyzer
  • RTCA HT Control Unit
  • E-Plate 384

The RTCA HT Station is used in combination with the RTCA HT Analyzer, RTCA HT Control Unit, and E-Plates 384 to perform real-time, label-free cell-based assays in automated high-throughput screening.

The RTCA HT Station can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors. Up to four RTCA HT Stations can be linked to one RTCA HT Analyzer. The RTCA HT Station serves to transmit signals from an E-Plate 384 to the RTCA Analyzer.

The RTCA HT Analyzer is used in combination with the RTCA HT Station in highthroughput screening automation. It is an electronic analyzer that can, under the control of the RTCA HT Software, measure electronic impedance of sensor electrodes at various signal frequencies. The RTCA HT Analyzer is capable of computer-controlled signal generation, processing and analysis, automatic frequency scanning, and measurement.

The RTCA HT Control Unit consists of a desktop computer with 19” monitor. The operating system is pre-installed and ready for installation of the RTCA HT Software. The RTCA HT Control Unit is used in combination with the RTCA HT Analyzer and HT Stations to perform real-time, label-free cell-based screening assays.

E-Plate 384

The E-Plate 384 is used in combination with the RTCA HT Station, the RTCA HT Analyzer, and the RTCA HT Control Unit to perform real-time, label-free cellbased screening assays.

The E-Plate 384 is a single-use, disposable device that is similar to commonly used 384-well plates. Each of the 384 wells on the E-Plates 384 contains integral sensor electrode arrays so that cells inside each well can be monitored and assayed. The plate lid is designed to minimize evaporation. The E-Plate 384 is designed to be used at temperatures between +15°C and +40°C.

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